Results 51 to 60 of about 14,640,780 (243)

Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking [PDF]

, 2016
Histidine kinases are key components of regulatory networks in bacteria. Although many of these enzymes are bifunctional, mediating both phosphorylation and dephosphorylation of downstream targets, the molecular details of this central regulatory switch ...
Fucile, Geoffrey, Dubey, Badri N., Ozaki, Shogo, Schirmer, Tilman, Lori, Christian, Jenal, Urs, Plaza-Menacho, Ivan   +6 more
core   +1 more source

CYCLIC-AMP INHIBITION OF PHOSPHOINOSITIDE TURNOVER IN HUMAN-NEUTROPHILS

, 1986
The effect of increased intracellular levels of cyclic AMP on phosphoinositide metabolism was studied in human neutrophils stimulated with fMet-Leu-Phe.
V. DELLA BIANCA, L. M. VICENTINI, F. DI VIRGILIO, M. GRZESKOWIAK, P. De Togni, DELLA BIANCA, Vittorina, P. DETOGNI   +6 more
core   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

c-di-AMP Accumulation Regulates Growth, Metabolism, and Immunogenicity of Mycobacterium smegmatis

Frontiers in Microbiology, 2022
Cyclic dimeric adenosine monophosphate (c-di-AMP) is a ubiquitous second messenger of bacteria involved in diverse physiological processes as well as host immune responses.
Huanhuan Ning, Xuan Liang, Xuan Liang, Yanling Xie, Yanling Xie, Lu Bai, Lu Bai, Wei Zhang, Lifei Wang, Jian Kang, Yanzhi Lu, Yanling Ma, Guangchun Bai, Yinlan Bai   +13 more
doaj   +1 more source

Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription [PDF]

, 2023
The second messenger cyclic AMP regulates many nuclear processes including transcription, pre-mRNA splicing and mitosis. While most functions are attributed to protein kinase A, accumulating evidence suggests that not all nuclear cyclic AMP-dependent ...
Surdo, Nicoletta Concetta, Vismara, Mauro, Francesca Grisan, Ernesto Picardi, Bettio, Daniela, Lefkimmiatis, Konstantinos, Leonardo Salviati, Marco Lolicato, Milanesi, Luciano, Cristina Arrigoni, D'Erchia, Anna Maria, Grisan, Francesca, Luciano Milanesi, Picardi, Ernesto, Iannucci, Liliana Felicia, Giulietta Di Benedetto, Konstantinos Lefkimmiatis, Pesole, Graziano, Liliana Felicia Iannucci, Graziano Pesole, Anna Maria D’Erchia, Arrigoni, Cristina, Musso, Deborah, Salviati, Leonardo, Lolicato, Marco, Daniela Bettio, Mauro Vismara, Nicoletta Concetta Surdo, Di Benedetto, Giulietta, Deborah Musso, Conca, Filippo, Filippo Conca   +31 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

Microbiology Spectrum
The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu, Junmin Yao, Chengfeng Lei, Xiulian Sun   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Unconventional Cyclic di-GMP Signaling in Escherichia coli

, 2020
The species Escherichia coli represents an unfathomable variety of commensal, pathogenic, and environmental strains. The conventional cyclic di-GMP signaling in E.
Nikola Zlatkov, Uhlin, Bernt Eric,, Bernt Eric Uhlin, Zlatkov, Nikola,   +3 more
core   +1 more source