Results 31 to 40 of about 34,752 (95)
Structural basis for the inhibition of the Bacillus subtilis c-di-AMP cyclase CdaA by the phosphoglucomutase GlmM [PDF]
, 2021 Cyclic-di-adenosine monophosphate (c-di-AMP) is an important nucleotide signaling molecule that plays a key role in osmotic regulation in bacteria. c-di-AMP is produced from two molecules of ATP by proteins containing a diadenylate cyclase (DAC) domain ...
Morgan, Rhodri ML +6 more
core +1 more source
mBio, 2013 Listeria monocytogenes infection leads to robust induction of an innate immune signaling pathway referred to as the cytosolic surveillance pathway (CSP), characterized by expression of beta interferon (IFN-β) and coregulated genes.
Chelsea E. Witte +5 more
doaj +1 more source
Molecular analysis of adenylyl cyclase: Bacillus anthracis edema factor exotoxin [PDF]
, 2010 Bacillus anthracis causes anthrax disease and exerts its deleterious effects by the release of three exotoxins, i.e. lethal factor, protective antigen and edema factor EF), a highly active calmodulin-dependent adenylyl cyclase (AC). However, conventional
Mohammed, Hesham Hamada Taha
core +1 more source
Toxin ζ Triggers a Survival Response to Cope with Stress and Persistence
Frontiers in Microbiology, 2017 Bacteria have evolved complex regulatory controls in response to various environmental stresses. Protein toxins of the ζ superfamily, found in prominent human pathogens, are broadly distributed in nature.
María Moreno-del Álamo +3 more
doaj +1 more source
, 2014 The Gram-positive bacterium Bacillus subtilis encodes three diadenylate cyclases that synthesize the essential signaling nucleotide cyclic di-AMP. The activities of the vegetative enzymes DisA and CdaA are controlled by protein-protein interactions with ...
Lewis, Richard J. +10 more
core +1 more source
mBioCyclic purine nucleotides are important signal transduction molecules across all domains of life. 3′,5′-cyclic di-adenosine monophosphate (c-di-AMP) has roles in both prokaryotes and eukaryotes, while the signals that adjust intracellular c-di-AMP and ...
Yu Fu +6 more
doaj +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 4, April 2026.Interfering with nucleotide signaling pathways using small molecules represents a promising strategy to disrupt biofilm formation on biomaterial surfaces. This study reported a new approach for tethering small molecules onto polyurethane surfaces using a PEG long linker.
Jiale Liu +7 more
wiley +1 more source
Current status and future perspectives of multi‐modal bacteria‐based cancer therapies
Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.Bacteria exhibit inherent tumour‐targeting capabilities, particularly thriving in hypoxic tumour microenvironments (TMEs) and activating potent anti‐tumour immune responses through pathogen‐associated molecular patterns (PAMPs) and immunomodulation.
Shuai Fan +9 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 64, Issue 38, September 15, 2025.Intrinsically disordered loops within globular protein domains have long escaped structural biology. Here, Söldner et al. show that despite this disorder, an allosteric modulation is exerted in a secondary‐messenger receptor by binding of its secondary messenger.
Benedikt Söldner +4 more
wiley +1 more source
Advanced Science, Volume 12, Issue 5, February 3, 2025.This study successfully isolated small colony variant (SCV) strains from osteomyelitis samples and found that alterations in purine metabolism, and consequent increases in antibiotic resistance are typical features of SCV. Based on the finding that regulating purine metabolism can enhance SCV sensitivity to β‐lactams, a co‐delivery system of lonidamine
Tingwang Shi +11 more
wiley +1 more source