Results 51 to 60 of about 34,752 (95)
Advanced Science, Volume 11, Issue 28, July 24, 2024.This study provides insight into the mechanism of celastrol as a potentiator of β‐lactams against methicillin‐resistant Staphylococcus aureus (MRSA). Celastrol reduces the cellular c‐di‐AMP level by activating GdpP and increases muropeptides with shorter glycine branches that cannot be processed by PBP2a of MRSA, making MRSA susceptible to β‐lactams ...
Ji‐Hoon Kim +10 more
wiley +1 more source
MicrobiologyOpen, Volume 13, Issue 3, June 2024.The protein AgtB has a specific affinity for 5‐aminovalerate. In contrast, both PA0602 and PA4985 show a strong preference for GABA, with secondary affinities for 5‐aminovalerate and ethylenediamine. Despite these findings, there is no evidence to suggest that these solute‐binding proteins—PA0602, PA4985, and AgtB—have any role in activating the AgtS ...
Jean Paul Cerna‐Vargas, Tino Krell
wiley +1 more source
An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]
, 2009 Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core
A small step towards an important goal: fragment screen of the c‐di‐AMP‐synthesizing enzyme CdaA
Acta Crystallographica Section D, Volume 80, Issue 5, Page 350-361, May 2024.Crystallographic fragment screening of the bacterial target Listeria monocytogenes CdaA is reported.CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug‐resistant human pathogens. The enzymatic product of CdaA, cyclic di‐AMP, is a secondary messenger that is essential for the viability of many bacteria.
Piotr Neumann +6 more
wiley +1 more source
Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro [PDF]
, 2003 The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine ...
Dufès, Christine +4 more
core +4 more sources
How enzyme‐centered approaches are advancing research on cyclic oligo‐nucleotides
FEBS Letters, Volume 598, Issue 8, Page 839-863, April 2024.Cyclic nucleotides serve as second messengers throughout kingdoms of life and regulate various pathways. Here, we review recent milestones in cyclic nucleotide biology, focusing on different enzyme folds that synthesize these signals, their regulatory mechanisms, and pleiotropic downstream signaling events.
Simon J. Wenzl +1 more
wiley +1 more source
The interplay between StkP/PhpP phosphorylation pathway and diadenylate cyclase CdaA producing c-di-AMP in Streptococcus pneumoniae [PDF]
The interplay between StkP/PhpP phosphorylation pathway and diadenylate cyclase CdaA producing c-di-AMP in Streptococcus pneumoniae Second messengers have emerged as a new field of bacterial reasearch.
Beneš, Tomáš
core +1 more source
THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]
, 2010 Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID +1 more
core
Identification of the endogenous cyclic diadenylate phosphodiesterase.
, 2016 Correlation of cyclic diadenylate phosphodiesterase activity with a ≈ 66-kDa protein band. Two identical lanes of the same denaturing electrophoresis gel were loaded each with 24 μg of partially purified cyclic diadenylate phosphodiesterase (Fig 1).
Alicia Cabezas (148477) +6 more
core +1 more source
Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements [PDF]
, 2011 Neurons of the Grueneberg ganglion (GG) in the anterior nasal region of mouse pups respond to cool temperatures and to a small set of odorants. While the thermosensory reactivity appears to be mediated by elements of a cyclic guanosine monophosphate ...
Biel, Martin +6 more
core +1 more source