Results 61 to 70 of about 34,752 (95)

Tetracyclic homoisoflavanoid (+)-brazilin: a natural product inhibits c-di-AMP-producing enzyme and Streptococcus mutans biofilms

Microbiology Spectrum
The tenacious biofilms formed by Streptococcus mutans are resistant to conventional antibiotics and current treatments. There is a growing need for novel therapeutics that selectively inhibit S.
Edwin M. Rojas, Hua Zhang, Sadanandan E. Velu, Hui Wu   +3 more
doaj   +1 more source

Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea

Nature Communications
c-di-AMP is an essential and widespread nucleotide second messenger in bacterial signaling. For most c-di-AMP synthesizing organisms, c-di-AMP homeostasis and the molecular mechanisms pertaining to its signal transduction are of great concern.
Di You, Liu-Chang Zhao, Yu Fu, Zhi-Yao Peng, Zong-Qin Chen, Bang-Ce Ye   +5 more
doaj   +1 more source

The regulation of the cAMP signalling pathway in the human pathogenic fungus Paracoccidioides brasiliensis [PDF]

, 2008
Paracoccidioides brasiliensis (Pb) is the causative agent of the disease Paracoccioidomycosis (PCM), which is one of the most prevalent systemic mycoses in Latin Amercia (Borges-Walmsley et al., 2002). P.
Janganan, Thamarai kannan
core  

Cell signalling in Paracoccidioides Brasiliensis [PDF]

, 2006
Paracocidioides brasiliensis (P. brasiliensis or Pb) is the etiological agent of paracocidioidomycosis which is the most prevalent systemic mycosis in South America.
Chen, Daliang
core  

Characterization of MRIP2 as a NO-sensitive guanylyl cyclase-associated protein [PDF]

, 2009
Poster presentation: NO-sensitive guanylyl cyclases (sGCs) are cytosolic receptors for nitric oxide (NO) catalyzing the conversion of GTP to cGMP. sGCs are obligate heterodimers composed of one alpha and beta subunit each. The allosteric mechanism of sGC
Meurer, Sabine, Müller-Esterl, Werner, Groß, Steffen, Matt, Simone   +3 more
core   +1 more source

Cyclase-Associated Protein Cap with Multiple Domains Contributes to Mycotoxin Biosynthesis and Fungal Virulence in Aspergillus flavus

, 2019
In Aspergillus, the cyclic adenosine monophosphate (cAMP) signaling modulates asexual development and mycotoxin biosynthesis. Here, we characterize the cyclase-associated protein Cap in the pathogenic fungus Aspergillus flauvs.
Kunlong Yang (5577824), Sen Wang (135167), Lianghuan Wu (2851622), Huahui Lan (6559769), Rui Xie, Huahui Lan, Opemipo Esther Fasoyin (6559772), Yinghang Liu (6559766), Sen Wang, Lianghuan Wu, Shihua Wang, Yu Wang (12152), Rui Xie (826938), Opemipo Esther Fasoyin, Shihua Wang (219946), Yu Wang, Yinghang Liu, Kunlong Yang   +17 more
core   +1 more source

Structural elucidation of the multidomain response regulator PleD using X-ray crystallography [PDF]

, 2004
c-diGMP (bis-(3!5)-cyclic di-guanosine monophosphate) is used extensively in bacteria to control biofilm formation and is lately postulated as a novel secondary messenger.
Chan, Carmen
core   +1 more source

Bacterial diadenylate cyclase domains synthesize diverse nucleotide signals in anti-phage defense

Bacterial diadenylate cyclase (DAC) enzymes synthesize the nucleotide signal 3′3′ cyclic di-AMP (3′3′-c-di-AMP) to control osmoregulation, cell-wall homeostasis, and DNA-damage responses.
Danielle J Haley, Philip J Kranzusch, Adelyn E Ragucci   +2 more
core   +1 more source

Cyclic GMP in the pig vitreous and retina after experimental retinal detachment [PDF]

, 2008
Purpose: Earlier studies have revealed a decreased level of cGMP in vitreous fluid obtained from patients with a retinal detachment. To further investigate this phenomenon, we developed an experimental retinal detachment model in pigs.
Heij, E.C., La, La Heij, Ellen C, Diederen, R., Diederen, Roselie M H, Lemmens, Marijke A M, de Vente, Jan, De Vente, J., La Heij, E.C., Lemmens, M.A.M., Kijlstra, Aize, Vente, J., De, Hendrikse, F., Hendrikse, Fred, Kijlstra, A.   +13 more
core  

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source