Results 81 to 90 of about 34,752 (95)

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates

Molecular Cell, 2008
To reveal mechanisms of DNA damage checkpoint initiation, we structurally and biochemically analyzed DisA, a protein that controls a Bacillus subtilis sporulation checkpoint in response to DNA double-strand breaks. We find that DisA forms a large octamer
Karl-Peter Hopfner, Gregor Witte
exaly   +2 more sources

Phenotypes Associated with the Essential Diadenylate Cyclase CdaA and Its Potential Regulator CdaR in the Human Pathogen Listeria monocytogenes

Journal of Bacteriology, 2016
Cyclic diadenylate monophosphate (c-di-AMP) is a second messenger utilized by diverse bacteria. In many species, including the Gram-positive human pathogen Listeria monocytogenes, c-di-AMP is essential for growth. Here we show that the single diadenylate
Johannes Gibhardt, Sven Halbedel, Fabian M Commichau   +2 more
exaly   +2 more sources

Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes

Journal of Biological Chemistry, 2015
The recently identified second messenger cyclic di-AMP (c-di-AMP) is involved in several important cellular processes, such as cell wall metabolism, maintenance of DNA integrity, ion transport, transcription regulation, and allosteric regulation of ...
Jörg Stülke, Ralf Ficner, Piotr Neumann   +2 more
exaly   +2 more sources

Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria

Current Genetics, 2016
Bacteria can sense environmental cues and alter their physiology accordingly through the use of signal transduction pathways involving second messenger nucleotides.
Zhao-Xun Liang, Mark Turner, Esteban Marcellin   +2 more
exaly   +2 more sources

Cyclic‐di‐AMPsynthesis by the diadenylate cyclaseCdaAis modulated by the peptidoglycan biosynthesis enzymeGlmMinLactococcus lactis [PDF]

Molecular Microbiology, 2016
© 2016 John Wiley & Sons Ltd. The second messenger cyclic-di-adenosine monophosphate (c-di-AMP) plays important roles in growth, virulence, cell wall homeostasis, potassium transport and affects resistance to antibiotics, heat and osmotic stress.
Yan Zhu, Lars Keld Nielsen, Yuanliang Wang   +2 more
exaly   +3 more sources

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3′-dATP

Biochemical Journal, 2015
The identification of the essential bacterial second messenger cyclic-di-AMP (c-di-AMP) synthesized by the DNA-integrity scanning protein A (DisA) has opened up a new and emerging field in bacterial signalling. To further analyse the diadenylate cyclase (
Karl-Peter Hopfner, Gregor Witte
exaly   +2 more sources

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IPA-3: An Inhibitor of Diadenylate Cyclase of Streptococcus suis with Potent Antimicrobial Activity

Antibiotics, 2022
Tingting Li, Qi Huang, Rui Zhou
exaly  

The Diadenylate Cyclase CdaA Is Critical for Borrelia turicatae Virulence and Physiology

Infection and Immunity, 2021
Jon Blevins, Renny Lan, Cheta Siletti
exaly  

All DACs in a Row: Domain Architectures of Bacterial and Archaeal Diadenylate Cyclases

Journal of Bacteriology, 2023
Michael Y Galperín
exaly  

Highly efficient enzymatic preparation of c-di-AMP using the diadenylate cyclase DisA from Bacillus thuringiensis

Enzyme and Microbial Technology, 2013
Jin He, Jianmei Su, Jieping Wang
exaly