Results 41 to 50 of about 34,752 (95)

Protein allostery. computational characterization of diguanylate cyclase PleD [PDF]

, 2009
In biology, accurate cellular regulation in response to environmental signals is crucial for the fitness of organisms. On the molecular level the modulation of protein activity is often achieved by the binding of a signaling molecule or by covalent ...
Schmid, Franziska F.-F.
core   +1 more source

Biological and Biochemical Roles of Two Distinct Cyclic Dimeric Adenosine 3′,5′-Monophosphate- Associated Phosphodiesterases in Streptococcus mutans

Frontiers in Microbiology, 2018
Cyclic dimeric adenosine 3′,5′-monophosphate (c-di-AMP), a recently identified secondary messenger in bacteria, plays a role in several bacterial processes, including biofilm formation. It is enzymatically produced by diadenylate cyclase and cleaved by c-
Hiroyasu Konno, Hiroyasu Konno, Yasuo Yoshida, Keiji Nagano, Jun Takebe, Yoshiaki Hasegawa   +5 more
doaj   +1 more source

A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists

Advanced Science, Volume 12, Issue 3, January 20, 2025.
The PBNV system provides extensive antiviral effectiveness via the following mechanisms: (1) self‐assembly of diverse nanoparticles; (2) self‐catalyzed production of small‐molecule STING agonists; and (3) delivery vectors aimed at the cytosolic surveillance system.
Yu‐an Li, Yi Feng, Wenjing Li, Yuqin Zhang, Yanni Sun, Shifeng Wang, Roy Curtiss III, Huoying Shi   +7 more
wiley   +1 more source

c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress.

PLoS Pathogens, 2011
The cell wall is a vital and multi-functional part of bacterial cells. For Staphylococcus aureus, an important human bacterial pathogen, surface proteins and cell wall polymers are essential for adhesion, colonization and during the infection process ...
Rebecca M Corrigan, James C Abbott, Heike Burhenne, Volkhard Kaever, Angelika Gründling   +4 more
doaj   +1 more source

Characterization of c‐di‐AMP signaling in the periodontal pathobiont, Treponema denticola

Molecular Oral Microbiology, Volume 39, Issue 5, Page 354-367, October 2024.
Abstract Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown.
Aidan D. Moylan, Dhara T. Patel, Claire O'Brien, Edward J. A. Schuler, Annie N. Hinson, Richard T. Marconi, Daniel P. Miller   +6 more
wiley   +1 more source

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase [PDF]

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source

Regulation of potassium homeostasis in Mycoplasma bovis by the diadenylate cyclase CdaM

Frontiers in Microbiology
Cyclic di-AMP (c-di-AMP) is a critical second messenger in many Gram-positive bacteria and archaea that regulates intracellular potassium (K+) concentrations, ensuring osmotic balance.
Jiongxi Chen, Jiongxi Chen, Jiongxi Chen, Jiongxi Chen, Jiongxi Chen, Doukun Lu, Doukun Lu, Doukun Lu, Doukun Lu, Doukun Lu, Yingjie Fu, Yingjie Fu, Yingjie Fu, Yingjie Fu, Yingjie Fu, Tahira Iftakhar, Tahira Iftakhar, Tahira Iftakhar, Tahira Iftakhar, Tahira Iftakhar, Zhiyu Hao, Zhiyu Hao, Zhiyu Hao, Zhiyu Hao, Zhiyu Hao, Menghan Zhang, Menghan Zhang, Menghan Zhang, Menghan Zhang, Menghan Zhang, Xi Chen, Xi Chen, Xi Chen, Xi Chen, Xi Chen, Yingyu Chen, Yingyu Chen, Yingyu Chen, Yingyu Chen, Yingyu Chen, Changmin Hu, Changmin Hu, Changmin Hu, Changmin Hu, Changmin Hu, Jianguo Chen, Jianguo Chen, Jianguo Chen, Jianguo Chen, Jianguo Chen, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Lei Zhang, Gang Zhao, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +60 more
doaj   +1 more source

Crystallographic fragment screen of the c‐di‐AMP‐synthesizing enzyme CdaA from Bacillus subtilis

Acta Crystallographica Section F, Volume 80, Issue 9, Page 200-209, September 2024.
The crystal structure determination of CdaA enzymes from Streptococcus pneumoniae, Bacillus subtilis and Enterococcus faecium is reported. Additionally, the structural results of a fragment screen of B. subtilis CdaA are presented, along with a subsequent in silico drug‐repurposing screen conducted using the OpenEye suite.Crystallographic fragment ...
Tim Garbers, Piotr Neumann, Jan Wollenhaupt, Achim Dickmanns, Manfred S. Weiss, Ralf Ficner   +5 more
wiley   +1 more source

Selenomonas sputigena: Growth Conditions and Projected Virulence Factors of an Emerging Oral Pathogen [PDF]

, 2020
Periodontal diseases are ubiquitous diseases. They can affect people through a chronic infection that happens over a lifetime, but also as an aggressive infection that afflicts the younger population. It not only results in tooth loss and a lower quality
Keller, Kayla A
core   +1 more source

Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2019
Bacillus Calmette-Guerin (BCG) is a live attenuated vaccine against tuberculosis (TB) and remains the most commonly used vaccine worldwide. However, BCG has varied protective efficiency in adults and has safety concerns in immunocompromised population ...
Huanhuan Ning, Huanhuan Ning, Lifei Wang, Jie Zhou, Yanzhi Lu, Jian Kang, Tianbing Ding, Tianbing Ding, Lixin Shen, Zhikai Xu, Yinlan Bai   +10 more
doaj   +1 more source