Results 11 to 20 of about 272,599 (253)

Zinc: an endogenous and exogenous regulator of platelet function during hemostasis and thrombosis

Platelets, 2021
Zinc (Zn2+) is an essential micronutrient and the second most abundant trace metal in the human body. The important role that Zn2+ plays in hemostasis is exemplified by platelet-related bleeding phenotypes coinciding with dietary Zn2+ deficiency.
Niaz Shahed Ahmed, MariaElisa Lopes-Pires, Nicholas Pugh   +2 more
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The second messenger c-di-AMP controls natural competence via ComFB signaling protein [PDF]

Cell Discovery
Sherihan Samir, Sofía Doello, Andreas M. Enkerlin, Erik Zimmer, Michael Haffner, Teresa Müller, Lisa Dengler, Stilianos P. Lambidis, Shamphavi Sivabalasarma, Sonja-Verena Albers, Khaled A. Selim   +10 more
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Relationship between Ca2+ and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells

Endocrine Journal, 2023
In adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear.
Masahiko Kutsukake, Naoko Kuwabara, Yoshikazu Miyate, Kenzo Kudo, Shoko Goto, Eiichi Taira, Eiichi Tachikawa   +6 more
doaj   +1 more source

β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

eLife, 2020
Cardiomyocyte β3-adrenoceptors (β3-ARs) coupled to soluble guanylyl cyclase (sGC)-dependent production of the second messenger 3’,5’-cyclic guanosine monophosphate (cGMP) have been shown to protect from heart failure.
Sophie Schobesberger, Peter T Wright, Claire Poulet, Jose L Sanchez Alonso Mardones, Catherine Mansfield, Andreas Friebe, Sian E Harding, Jean-Luc Balligand, Viacheslav O Nikolaev, Julia Gorelik   +9 more
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Direct LC-MS/MS Analysis of Extra- and Intracellular Glycerophosphoinositol in Model Cancer Cell Lines

Frontiers in Immunology, 2021
Glycerophosphoinositols (GPIs) are water-soluble bioactive phospholipid derivatives of increasing interest as intracellular and paracrine mediators of eukaryotic cell functions.
Ana Margarida Campos, Ana Margarida Campos, Genoveffa Nuzzo, Alessia Varone, Paola Italiani, Diana Boraschi, Daniela Corda, Daniela Corda, Angelo Fontana, Angelo Fontana   +9 more
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An auto-inhibited state of protein kinase G and implications for selective activation

eLife, 2022
Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance ...
Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan VanSchouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R MacKenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim   +12 more
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Photosensitive neurons in mollusks [PDF]

Archives of Biological Sciences, 2005
In addition to regular photoreceptors, some invertebrates possess simple extra ocular photoreceptors. For ex­ample, the central ganglia of mollusks contain photosensitive neurons.
Kartelija Gordana, Nedeljković M., Radenović Lidija Lj.   +2 more
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Plasmodium falciparum cGMP-Dependent Protein Kinase – A Novel Chemotherapeutic Target

Frontiers in Microbiology, 2021
The primary effector of cGMP signaling in Plasmodium is the cGMP-dependent protein kinase (PKG). Work in human-infective Plasmodium falciparum and rodent-infective Plasmodium berghei has provided biological validation of P.
David Rotella, John Siekierka, Purnima Bhanot   +2 more
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Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium

Cells, 2020
Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform.
Philipp Tschaikner, Florian Enzler, Omar Torres-Quesada, Pia Aanstad, Eduard Stefan   +4 more
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Nitric Oxide: The Coming of the Second Messenger

Rambam Maimonides Medical Journal, 2011
(Excerpt) The concept of communications between cells or cell signaling dates back over 100 years to Pavlov. He discovered that neuronal signals, first generated by the smell of food and later by the ringing of a bell, enhanced gastric secretion.
Ferid Murad
doaj   +1 more source