Results 1 to 10 of about 1,793 (129)

Ryanodine Receptor 1 Is Dispensable for CD4⁺ T-Cell Differentiation and Effector Function in Intestinal Inflammation Models. [PDF]

Eur J Immunol
Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation.
Dostiar Tabrizi S, Nawrocki M, Bedke T, Böttcher M, Stumme F, Birus M, Möckl F, Hernandez L, Diercks BP, Gagliani N, Lodygin D, Flügel A, Guse AH, Mittrücker HW, Huber S.   +14 more
europepmc   +2 more sources

The Na⁺/K⁺-ATPase β1 Subunit is a Kidney ADP-Ribosyl Cyclase. [PDF]

FASEB J
This study highlights that the β1 subunit of Na, K‐ATPase, known as Atp1b1, functions as an ADP‐ribosyl cyclase in rat kidney (kARC). We found that reducing Atp1b1 expression in mouse mesangial cells suppressed angiotensin II (AngII)–induced synthesis of cyclic ADP‐ribose (cADPR) and the associated sustained Ca2+ signaling.
Nam TS, Choe SK, Kim UH.
europepmc   +2 more sources

MASTER-NAADP: a membrane permeable precursor of the Ca2+ mobilizing second messenger NAADP [PDF]

Nature Communications
Upon stimulation of membrane receptors, nicotinic acid adenine dinucleotide phosphate (NAADP) is formed as second messenger within seconds and evokes Ca2+ signaling in many different cell types.
Sarah Krukenberg, Franziska Möckl, Mariella Weiß, Patrick Dekiert, Melanie Hofmann, Fynn Gerlach, Kai J. Winterberg, Dejan Kovacevic, Imrankhan Khansahib, Berit Troost, Macarena Hinrichs, Viviana Granato, Mikolaj Nawrocki, Tobis Hub, Volodymyr Tsvilovskyy, Rebekka Medert, Lena-Marie Woelk, Fritz Förster, Huan Li, René Werner, Marcus Altfeld, Samuel Huber, Oliver Biggs Clarke, Marc Freichel, Björn-Philipp Diercks, Chris Meier, Andreas H. Guse   +26 more
doaj   +2 more sources

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Mediated Calcium Signaling Is Active in Memory CD4⁺ T Cells [PDF]

Molecules
Nicotinic acid adenine dinucleotide phosphate (NAADP), identified as one of the most potent calcium-mobilizing second messengers, has been studied in different eukaryotic cell types, including lymphocytes.
Anish Chakraborty, Ravindika Dissanayake, Katherine A. Wall   +2 more
doaj   +2 more sources

Two-pore channel regulators - Who is in control? [PDF]

Frontiers in Physiology
Two-pore channels (TPCs) are adenine nucleotide and phosphoinositide regulated cation channels. NAADP activates and ATP blocks TPCs, while the endolysosomal phosphoinositide PI(3,5)P2 activates TPCs.
Rebecca Deutsch, Veronika Kudrina, Marc Freichel, Marc Freichel, Christian Grimm, Christian Grimm   +5 more
doaj   +2 more sources

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism [PDF]

Nature Communications
Tetrandrine (Tet) is a potent inhibitor of Ebola virus replication by blocking NAADP-dependent calcium release through endolysosomal two-pore channels (TPCs) and a moderately potent anti-tumor agent.
Wing-Cheung Chan, Qian Zhao, Koon Ho Wong, Hok-Him Tang, Daniel Kam-Wah Mok, Lakhansing Pardeshi, Ye Chun Ruan, Yang Yang, Chi-Ming Wong, Clarence T. T. Wong, Yong-Juan Zhao, Ka Ying Chan, Zengsheng Yin, Howard Ho-Wai Leung, Xiyang Ma, Mary P. Chau, Franco King-Chi Leung, Ying-Ying Lui, Shannon Wing-Ngor Au, Kailei Sun, Chin Yu Mok, Fang Wang, Cong Ma, Yu-Hin Ho, Xiang-Yang Ye, Man Lung Yeung, Yajing Zhang, Yan Xiang Zhao, Jiang Liu, Ka-Hing Wong, Larry M. C. Chow, Xiang David Li, Gary M. Tse, Man-Kin Wong, Xiao Shen, Pauline Chiu, Ben C. B. Ko   +36 more
doaj   +2 more sources

Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking [PDF]

Cells
The endolysosomal system plays a pivotal role in cellular function. Before reaching lysosomes for degradation, the endocytosed cargoes are sorted at various stages of endosomal trafficking for recycling and/or rerouting.
Heng Zhang, Michael X. Zhu
doaj   +2 more sources

Metabotropic Glutamate Receptor-Dependent Synaptic Plasticity in Age-Related Neurodegenerative Disorders. [PDF]

Neural Plast
Synaptic plasticity is a fundamental property of the nervous system that underpins learning, memory, and adaptive behavior across the lifespan. Disruption of plasticity mechanisms is increasingly recognized as a unifying feature of age‐related neurodegenerative and neuropsychiatric disorders.
Basha S, Vijeev A, Nadig SS, Agarwal K, Meharchandani V, Pai AR, Mahato KK.   +6 more
europepmc   +2 more sources

Two-pore channel-2 controls calmodulin-dependent STIM1 inactivation [PDF]

Nature Communications
Lysosomal two-pore channels (TPC) trigger Ca2+ release from the endoplasmic reticulum (ER). The ensuing ER Ca2+ depletion activates STIM1-gated store-operated Ca2+ entry (SOCE) channels that sustain Ca2+ signals regulating fundamental cellular processes.
Subo Lee, Raphael Néré, Kyoung Sun Park, Vincent Jaquet, Nicolas Demaurex, Kyu-Sang Park   +5 more
doaj   +2 more sources

JPT2 Affects Trophoblast Functions and Macrophage Polarization and Metabolism, and Acts as a Potential Therapeutic Target for Recurrent Spontaneous Abortion. [PDF]

Adv Sci (Weinh)
Dysregulated Jupiter microtubule‐associated homolog 2 (JPT2) at the maternal–fetal interface leads to recurrent spontaneous abortion (RSA) development. The present study shows that JPT2 deficiency inhibits trophoblast function. Furthermore, the lack of JPT2 in trophoblasts contributes to M1 macrophage polarization by promoting the accumulation of ...
Chen X, Song QL, Ji R, Wang JY, Cao ML, Guo DY, Zhang Y, Yang J.   +7 more
europepmc   +2 more sources