Results 11 to 20 of about 1,793 (129)

NAADP-sensitive Сa(2+) stores in permeabilized rat hepatocytes [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2014
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a nucleotide that is potent to release calcium from intracellular stores in different cell types.
S. V. Bychkova, T. I. Chorna
doaj   +1 more source

Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide—Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice

open access: yesCells, 2021
Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca2+ mobilizing agent and its inhibition proved to inhibit T-cell activation.
Mikołaj Nawrocki   +9 more
doaj   +1 more source

Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

open access: yesFrontiers in Cell and Developmental Biology, 2022
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca2+ release.
Pawan Faris   +6 more
doaj   +1 more source

Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

open access: yesNature Communications, 2021
Nicotinic acid adenine dinucleotide phosphate (NAADP) potent Ca2+ mobilizing second messenger which uniquely triggers Ca2+ release from acidic endolysosomal organelles.
Jiyuan Zhang   +3 more
doaj   +1 more source

NAADP: From Discovery to Mechanism

open access: yesFrontiers in Immunology, 2021
Nicotinic acid adenine dinucleotide 2’-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms.
Timothy F. Walseth, Andreas H. Guse
doaj   +1 more source

NAADP Signaling: New Kids on the Block

open access: yesCells, 2022
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a universal Ca2+ mobilizing second messenger essential for initiation of Ca2+ signaling. Recently, novel molecular mechanisms of both its rapid formation upon receptor stimulation and its mode of ...
Andreas H. Guse
doaj   +1 more source

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. [PDF]

open access: yesPLoS ONE, 2016
Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the underlying mechanisms remain poorly understood. We investigated the role of Ca2+-mobilizing second messengers, NAADP and cADPR, in the cardiac hypertrophy induced by β ...
Rukhsana Gul   +9 more
doaj   +1 more source

The role of bafilomycin as a therapeutic agent in the modulation of endo-lysosomal store of rat hepatocytes

open access: yesMedičnì Perspektivi, 2022
Endo-lysosomal system through the process of autophagy is involved in the pathogenesis of many diseases. Acidification of these organelles is carried out by V-type H+-ATPases, which is inhibited by bafilomycin A1.
S.V.  Bychkova   +2 more
doaj   +1 more source

ATPase Activity of the Subcellular Fractions of Colorectal Cancer Samples under the Action of Nicotinic Acid Adenine Dinucleotide Phosphate

open access: yesBiomedicines, 2021
In tumor cells with defects in apoptosis, autophagy allows prolonged survival. Autophagy leads to an accumulation of damaged mitochondria by autophagosomes.
Ivan Kushkevych   +5 more
doaj   +1 more source

Ca2+ releasing process and nicotinic acid adenine dinucleotide phosphate

open access: yesБіологічні студії, 2013
The paper is devoted to recognizing of nicotinic acid adenine dinucleotide phosphate (NAADP) as releaser of intracellular calcium from intracellular stores.
S. Bychkova
doaj   +1 more source

Home - About - Disclaimer - Privacy