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Lysosome transport as a function of lysosome diameter. [PDF]
PLoS ONE, 2014 Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay +4 more
doaj +2 more sources
Cell Discovery, 2020 Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. The most well-studied form of autophagy is macroautophagy, which delivers cytoplasmic material to lysosomes via the double-membraned ...
Mizushima Noboru, Willa Wen-You Yim
exaly +2 more sources
Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Nature Reviews Molecular Cell BiologyAutophagy is a lysosome-based degradative process used to recycle obsolete cellular constituents and eliminate damaged organelles and aggregate-prone proteins.
David C. Rubinsztein, Ralph A. Nixon
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Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
Nature, 2018 Both mitochondria and lysosomes are essential for maintaining cellular homeostasis, and dysfunction of both organelles has been observed in multiple diseases.
Yvette C Wong +2 more
exaly +2 more sources
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.
PLoS ONE, 2021 Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi +6 more
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Nature Communications, 2022 Targeted protein degradation allows targeting undruggable proteins for therapeutic applications as well as eliminating proteins of interest for research purposes.
Chang-Hoon Ji +21 more
semanticscholar +1 more source
Orphanet Journal of Rare Diseases, 2021 Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn +3 more
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Lysosome biogenesis: Regulation and functions
Journal of Cell Biology, 2021 Yang and Wang review the mechanisms regulating lysosome biogenesis and functions during the cellular response to diverse environmental cues and in organismal development and aging.
Chonglin Yang, Xiaochen Wang
semanticscholar +1 more source
Science, 2023 Targeted protein degradation can provide advantages over inhibition approaches in the development of therapeutic strategies. Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6–phosphate receptor (CI-M6PR), to
Green Ahn +7 more
semanticscholar +1 more source
Nature Communications, 2023 Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis ...
Tian-Shu Hao +11 more
semanticscholar +1 more source