Results 1 to 10 of about 180,932 (288)
Lysosome transport as a function of lysosome diameter. [PDF]
PLoS ONE, 2014 Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay +4 more
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Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.
PLoS ONE, 2021 Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi +6 more
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The role of lysosome in regulated necrosis
Acta Pharmaceutica Sinica B, 2020 Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention.
Yang Wang, Yu-Quan Wei
exaly +3 more sources
Orphanet Journal of Rare Diseases, 2021 Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn +3 more
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Scientific Reports, 2021 We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet +7 more
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ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
Nature Communications, 2021 In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan +9 more
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Orphanet Journal of Rare Diseases, 2018 Background Rare diseases are often un- or misdiagnosed for extended periods, resulting in a long diagnostic delay that may significantly add to the burden of the disease.
Gé-Ann Kuiper +3 more
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Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells
Frontiers in Bioscience-Landmark, 2020 Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial barrier dysfunction with endothelial hyperpermeability.
Youzhi Zhang +5 more
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A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. [PDF]
PLoS ONE, 2016 Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to
Magdalena L Circu +7 more
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Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice
Neurobiology of Disease, 2009 Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the α-galactosidase gene (GLA). Loss of α-galactosidase (α-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of ...
L.G. Rodrigues +7 more
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