Lysosome-endosome fusion and lysosome biogenesis [PDF]
Journal of Cell Science, 2000 ABSTRACT Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a hybrid ...
J P, Luzio +5 more
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The Biogenesis of Lysosomes and Lysosome-Related Organelles [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are
J Paul, Luzio +3 more
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Orphanet Journal of Rare Diseases, 2018 Background Rare diseases are often un- or misdiagnosed for extended periods, resulting in a long diagnostic delay that may significantly add to the burden of the disease.
Gé-Ann Kuiper +3 more
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Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells
Frontiers in Bioscience-Landmark, 2020 Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial barrier dysfunction with endothelial hyperpermeability.
Youzhi Zhang +5 more
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A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. [PDF]
PLoS ONE, 2016 Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to
Magdalena L Circu +7 more
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Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice
Neurobiology of Disease, 2009 Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the α-galactosidase gene (GLA). Loss of α-galactosidase (α-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of ...
L.G. Rodrigues +7 more
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Lysosome assembly and disassembly changes endocytosis rate through the Leishmania cell cycle
MicrobiologyOpen, 2020 The Leishmania lysosome has an atypical structure, consisting of an elongated vesicle‐filled tubule running along the anterior–posterior axis of the cell, which is termed the multivesicular tubule (MVT) lysosome.
Ziyin Wang +2 more
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Alginate oligosaccharides can maintain activities of lysosomes under low pH condition
Scientific Reports, 2021 The objective of this study was to report that lysosome extracted from egg white could be used as a drug through oral administration for treating diseases by using pH sensitive alginate oligosaccharides.
Ra-Mi Park +4 more
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Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with
Kevin Gee +11 more
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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants. [PDF]
PLoS ONE, 2014 Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing
Jürgen Brojatsch +6 more
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