Results 21 to 30 of about 254,260 (291)

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Nature Communications, 2021
In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías   +9 more
doaj   +1 more source

Current methods to analyze lysosome morphology, positioning, motility and function

Traffic : the International Journal of Intracellular Transport, 2022
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles. Lysosomes were regarded as exclusively degradative organelles, but more recent research has shown that they play essential roles in ...
Duarte C. Barral, Leopoldo Staiano, Cláudia Guimas Almeida, D. Cutler, E. Eden, C. Futter, A. Galione, A. Marques, D. Medina, G. Napolitano, C. Settembre, O. V. Vieira, J. Aerts, Peace Atakpa-Adaji, Gemma Bruno, A. Capuozzo, E. De Leonibus, Chiara Di Malta, Cristina Escrevente, Alessandra Esposito, P. Grumati, Michael J. Hall, Rita O. Teodoro, S. Lopes, J. Luzio, J. Monfregola, S. Montefusco, F. Platt, R. Polishchuck, M. D. de Risi, Irene Sambri, C. Soldati, M. Seabra   +32 more
semanticscholar   +1 more source

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.

Neurobiology of Disease, 2021
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative disorders that are thought to exist on a clinical and pathological spectrum. FTD and ALS are linked by shared genetic causes (i.e.
Jessica Root, Paola Merino, A. Nuckols, Michelle A. Johnson, Thomas L. Kukar   +4 more
semanticscholar   +1 more source

Lysosome-targeting chimaeras for degradation of extracellular proteins

Nature, 2020
The majority of therapies that target individual proteins rely on specific activity-modulating interactions with the target protein—for example, enzyme inhibition or ligand blocking.
Steven M. Banik, Kayvon Pedram, Simon Wisnovsky, Green Ahn, N. Riley, C. Bertozzi   +5 more
semanticscholar   +1 more source

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Nature Communications, 2021
Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown.
Soojin Kim, Y. Wong, Fan-Ding Gao, D. Krainc   +3 more
semanticscholar   +1 more source

Failure to shorten the diagnostic delay in two ultra-orphan diseases (mucopolysaccharidosis types I and III): potential causes and implications

Orphanet Journal of Rare Diseases, 2018
Background Rare diseases are often un- or misdiagnosed for extended periods, resulting in a long diagnostic delay that may significantly add to the burden of the disease.
Gé-Ann Kuiper, Olga L. M. Meijer, Eveline J. Langereis, Frits A. Wijburg   +3 more
doaj   +1 more source

Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells

Frontiers in Bioscience-Landmark, 2020
Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial barrier dysfunction with endothelial hyperpermeability.
Youzhi Zhang, Yun-Ting Wang, Saisudha Koka, Yang Zhang, Tahir Hussain, Xiang Li   +5 more
doaj   +1 more source

Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

Trends in Neurosciences, 2022
Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles.
Jasmine Cisneros, Tayler B. Belton, George C Shum, Catherine G. Molakal, Y. Wong   +4 more
semanticscholar   +1 more source

Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis

, 2021
In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, which is characterized by an aberrant accumulation of undigested lipids within lysosomes.
Futter, Clare E., Santos, Nuno C., Lopes, Catarina S., Soares, Maria I. L., Padrão, Nuno, Alves, Liliana S., Ramalho, José, Marques, André R. A., Carvalho, Filomena A., Pinho e Melo, Teresa M. V. D., Vieira, Otília V., Nuno C. Santos, Filomena A. Carvalho, Teresa M. V. D. Pinho e Melo, Otília V. Vieira, Liliana S. Alves, José Ramalho, Catarina S. Lopes, Maria I. L. Soares, André R. A. Marques, Clare E. Futter, Nuno Padrão   +21 more
core   +1 more source

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. [PDF]

PLoS ONE, 2016
Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to
Magdalena L Circu, Samantha S Dykes, Jennifer Carroll, Kinsey Kelly, Floyd Galiano, Adam Greer, James Cardelli, Hazem El-Osta   +7 more
doaj   +1 more source