Results 21 to 30 of about 180,932 (288)

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival [PDF]

, 2015
Funding provided by: Wellcome Trust Technology Platform 097945/B/11/Z, MRC Next Generation Optical Microscopy MR/K015869/1, Medical Research Council, Division of Signal Transduction Therapy Unit (AstraZeneca, Boehringer‐Ingelheim, GlaxoSmithKline, Merck ...
Michael J Munson, Lucocq, John M., Rachel Toth, Toth, Rachel, Allen, George F. G., George Fg Allen, Ganley, Ian G.; id_orcid, David G Campbell, Ganley, Ian G., John M Lucocq, Ian G Ganley, Campbell, David G., Munson, Michael J.   +12 more
core   +1 more source

Lysosome-Targeting Aggregation-Induced Emission Nanoparticle Enables Adoptive Macrophage Transfer-Based Precise Therapy of Bacterial Infections

, 2023
Traditional antibacterial procedures are getting inefficient due to the emergence of antimicrobial resistance, which makes alternative treatments in urgent demand. However, the selectivity toward infectious bacteria is still challenging.
Peng Wang, Duo Mao, Chengjian Chen (4353559), Fang Hu (476414), Duo Mao (1444771), Biru Wu (15928369), Fang Hu, Peng Wang (34436), Guangxue Feng (1563565), Biru Wu, Bin Liu (5899), Min Li (12799), Yuchen Song, Min Li, Guangxue Feng, Yuchen Song (9524571), Chengjian Chen, Bin Liu   +17 more
core   +1 more source

Lysosome assembly and disassembly changes endocytosis rate through the Leishmania cell cycle

MicrobiologyOpen, 2020
The Leishmania lysosome has an atypical structure, consisting of an elongated vesicle‐filled tubule running along the anterior–posterior axis of the cell, which is termed the multivesicular tubule (MVT) lysosome.
Ziyin Wang, Richard J. Wheeler, Jack D. Sunter   +2 more
doaj   +1 more source

Alginate oligosaccharides can maintain activities of lysosomes under low pH condition

Scientific Reports, 2021
The objective of this study was to report that lysosome extracted from egg white could be used as a drug through oral administration for treating diseases by using pH sensitive alginate oligosaccharides.
Ra-Mi Park, Ngoc-Han Thi Nguyen, Su-Min Lee, Yang-Hoon Kim, Jiho Min   +4 more
doaj   +1 more source

The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei [PDF]

, 2015
Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and
Cynthia Y. He, Kevin S. W. Tan, Htay Mon Aye, Hazel Xinyu Koh   +3 more
core   +1 more source

Lysosome

Journal of Inborn Errors of Metabolism and Screening, 2016
Since Christian de Duve first described the lysosome in the 1950s, it has been generally presented as a membrane-bound compartment containing acid hydrolases that enables the cell to degrade molecules without being digested by autolysis.
Ursula Matte BSc, PhD, Gabriela Pasqualim BSc, MSc   +1 more
doaj   +1 more source

Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles [PDF]

, 2017
β-NaYF4:Yb,Gd up-conversion nanoparticles, UCNPs, surface functionalized with suitable targetting peptides function as nontoxic lysosome-specific imaging ...
Sreedharan, S., Nicola H. Green, Das, A., Thomas, J., Amitava Das, Pramanik, S.K., Sreejesh Sreedharan, Thomas, J.A., Jim. A. Thomas, Carl Smythe, Singh, H., Harwinder Singh, Sumit Kumar Pramanik, Smythe, C., Green, N.H.   +14 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins. [PDF]

FEBS Open Bio
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Ikeda K.
europepmc   +2 more sources

Lysosome Ca2+ Store Refilling Mechanisms. [PDF]

, 2015
Lysosomes are acidic intracellular vesicles containing hydrolases that degrade intracellular and extracellular debris delivered through endocytic trafficking and autophagy.
Garrity, Abigail G.
core   +7 more sources

Lysosome-Targeting Iridium(III) Probe with Near-Infrared Emission for the Visualization of NO/O₂^•‑ Crosstalk via In Vivo Peroxynitrite Imaging

, 2020
Nitric oxide (NO) and superoxide anions (O2•‑) are two noteworthy reactive species implicated in various physiological and pathological processes, such as ROS-induced lysosomal cell death.
Thomas W. Rees (4318561), Yu Chen, Xu Yan, Liangnian Ji (1504423), Hui Chao, Weijun Wu (6079913), Thomas W. Rees, Xinxing Liao (7009589), Cheng Zhang (70708), Yu Chen (29959), Xu Yan (110026), Hui Chao (1504435), Cheng Zhang, Xinxing Liao, Liangnian Ji, Weijun Wu   +15 more
core   +1 more source