Results 11 to 20 of about 254,260 (291)
Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with
Kevin Gee +11 more
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EMBO Molecular Medicine, 2016 In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, 2005). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer.
Andrea Ballabio
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High lumenal chloride in the lysosome is critical for lysosome function [PDF]
eLife, 2017 Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases.
Kasturi Chakraborty +2 more
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Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry
iScience, 2019 Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome ...
Kamalakannan Vijayan +9 more
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FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. [PDF]
PLoS ONE, 2016 The intracellular amino acid pool within lysosome is a signal that stimulates the nutrient-sensing mTORC1 signalling pathway. The signal transduction cascade has garnered much attention, but little is known about the sequestration of the signalling ...
Xiaochun Wu +6 more
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Spatio-temporal processes in autophagosome-lysosome fusion
Medical ReviewMacroautophagy/autophagy is a lysosome-dependent degradation process involved in cellular energy metabolism, recycling and quality control. Autophagy is a highly dynamic and precisely regulated process, which contains four major steps: autophagic ...
Liu Shizuo +4 more
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Lysosome Ca2+ Store Refilling Mechanisms. [PDF]
, 2015 Lysosomes are acidic intracellular vesicles containing hydrolases that degrade intracellular and extracellular debris delivered through endocytic trafficking and autophagy.
Garrity, Abigail G.
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Secretory autophagy maintains proteostasis upon lysosome inhibition
Journal of Cell Biology, 2022 Solvik et al. reveal that the autophagy machinery facilitates the secretion of autophagy cargo receptors and other cellular components via extracellular vesicles and particles in response to lysosome inhibition or impaired autophagosome maturation.
T. Solvik +7 more
semanticscholar +1 more source
Scientific Reports, 2021 We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet +7 more
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Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
EMBO Journal, 2022 Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is activated independently of ESCRT recruitment.
Maja Radulovic +11 more
semanticscholar +1 more source