Results 11 to 20 of about 222,748 (293)

Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice [PDF]

Nature Communications
The lysosome is a cell’s endogenous machinery responsible for degrading proteins. Here we describe two lysosome-targeting live attenuated vaccine approaches, LYTAR 1.0 and LYTAR 2.0, by harnessing the lysosome to conditionally degrade viral proteins of ...
Jiawei Hao, Ping Wang, Quan Shen, Xuetong Xi, Le Tong, Jihuan Hou, Le Li, Qikai Wang, Chengyao Liu, Jing Li, Huafang Zhao, Qisi Zhang, Roberto Plebani, David Chou, Lihe Zhang, Demin Zhou, Longlong Si   +16 more
doaj   +2 more sources

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.

PLoS ONE, 2021
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi, Evan Tang, Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena, Roberto J Botelho   +6 more
doaj   +1 more source

Reducing posttraumatic stress in parents of patients with a rare inherited metabolic disorder using eye movement desensitization and reprocessing therapy: a case study

Orphanet Journal of Rare Diseases, 2021
Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn, Lotte Haverman, Frits A. Wijburg, Carlijn De Roos   +3 more
doaj   +1 more source

Lysosome transport as a function of lysosome diameter. [PDF]

PLoS ONE, 2014
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay, Austin Cyphersmith, Jairo A Zapata, Y Joseph Kim, Christine K Payne   +4 more
doaj   +1 more source

Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Scientific Reports, 2021
We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski, Alexander M. Alzayed, Sophia DeGeorgia, Eve Schodowski, C. Alicia Traughber, Jonathan D. Smith   +7 more
doaj   +1 more source

Lysosomal labilization [PDF]

IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006
The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death.
A, Terman, T, Kurz, B, Gustafsson, U T, Brunk   +3 more
openaire   +2 more sources

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Nature Communications, 2021
In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías   +9 more
doaj   +1 more source

Failure to shorten the diagnostic delay in two ultra-orphan diseases (mucopolysaccharidosis types I and III): potential causes and implications

Orphanet Journal of Rare Diseases, 2018
Background Rare diseases are often un- or misdiagnosed for extended periods, resulting in a long diagnostic delay that may significantly add to the burden of the disease.
Gé-Ann Kuiper, Olga L. M. Meijer, Eveline J. Langereis, Frits A. Wijburg   +3 more
doaj   +1 more source

Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells

Frontiers in Bioscience-Landmark, 2020
Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial barrier dysfunction with endothelial hyperpermeability.
Youzhi Zhang, Yun-Ting Wang, Saisudha Koka, Yang Zhang, Tahir Hussain, Xiang Li   +5 more
doaj   +1 more source

Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis [PDF]

, 2017
Mutations in the co- chaperone protein, CSPα, cause an autosomal dominant, adult-neuronal ceroid lipofuscinosis (AD-ANCL). The current understanding of CSPα function exclusively at the synapse fails to explain the autophagy-lysosome pathway (ALP ...
Benitez, Bruno A, Sands, Mark S
core   +2 more sources