Results 11 to 20 of about 180,932 (288)
EMBO Molecular Medicine, 2016 In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, 2005). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer.
Andrea Ballabio
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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants. [PDF]
PLoS ONE, 2014 Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing
Jürgen Brojatsch +6 more
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High lumenal chloride in the lysosome is critical for lysosome function [PDF]
eLife, 2017 Lysosomes are organelles responsible for the breakdown and recycling of cellular machinery. Dysfunctional lysosomes give rise to lysosomal storage disorders as well as common neurodegenerative diseases.
Kasturi Chakraborty +2 more
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Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with
Kevin Gee +11 more
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Proteomics of the lysosome [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Defects in lysosomal function have been associated with numerous monogenic human diseases typically classified as lysosomal storage diseases. However, there is increasing evidence that lysosomal proteins are also involved in more widespread human diseases including cancer and Alzheimer disease.
Lübke, Torben +2 more
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Inducible Lysosome Renitence in Macrophages. [PDF]
Lysosomes are membrane-bounded intracellular compartments responsible for degradation of macromolecules and destruction of engulfed microbes. Extracellular molecules are taken up by pinocytosis in the case of soluble molecules and by phagocytosis in the
Davis, Michael J.
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BAP31 Drives Cartilage Calcification through Disruption of Autophagosome-Lysosome Fusion in Osteoarthritis. [PDF]
Adv Sci (Weinh)Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Xu ZH +13 more
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, 2022 In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, which is characterized by an aberrant accumulation of undigested lipids within lysosomes.
Futter, Clare E. +10 more
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Lysosome-endosome fusion and lysosome biogenesis [PDF]
Journal of Cell Science, 2000 ABSTRACT Recent data both from cell-free experiments and from cultured cells have shown that lysosomes can fuse directly with late endosomes to form a hybrid organelle. This has a led to a hypothesis that dense core lysosomes are in essence storage granules for acid hydrolases and that, when the former fuse with late endosomes, a ...
J P, Luzio +5 more
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The Biogenesis of Lysosomes and Lysosome-Related Organelles [PDF]
Cold Spring Harbor Perspectives in Biology, 2014 Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are
J Paul, Luzio +3 more
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