Results 11 to 20 of about 158,851 (164)

Lysosome transport as a function of lysosome diameter. [PDF]

PLoS ONE, 2014
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay, Austin Cyphersmith, Jairo A Zapata, Y Joseph Kim, Christine K Payne   +4 more
doaj   +4 more sources

Lysosome-centered nanomedicine for cancer therapy: mechanisms, materials, and modalities [PDF]

Journal of Nanobiotechnology
The lysosome, long regarded as a terminal degradative organelle, has emerged as a central and programmable hub for anticancer nanomedicine. Advances in materials science, chemical biology, and intracellular trafficking have enabled nanomaterials to ...
Rongwei Xu, Nina Li, Xu Chen, Meiyan Zou, Weiyao Feng, Zihao Zhou, Zhiyu Guo, Xinyuan Zhao, Shuguang Liu, Li Cui   +9 more
doaj   +2 more sources

The role of lysosome in regulated necrosis

Acta Pharmaceutica Sinica B, 2020
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention.
Aqu Alu, Xuejiao Han, Xuelei Ma
exaly   +3 more sources

Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice [PDF]

Nature Communications
The lysosome is a cell’s endogenous machinery responsible for degrading proteins. Here we describe two lysosome-targeting live attenuated vaccine approaches, LYTAR 1.0 and LYTAR 2.0, by harnessing the lysosome to conditionally degrade viral proteins of ...
Jiawei Hao, Ping Wang, Quan Shen, Xuetong Xi, Le Tong, Jihuan Hou, Le Li, Qikai Wang, Chengyao Liu, Jing Li, Huafang Zhao, Qisi Zhang, Roberto Plebani, David Chou, Lihe Zhang, Demin Zhou, Longlong Si   +16 more
doaj   +2 more sources

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation [PDF]

Advanced Science
Selective recognition of cancer‐associated proteins (CAPs) by antibodies, followed by their delivery into the intracellular organelle, the lysosome, results in targeted degradation of CAPs and suppresses the growth of cancer cells.
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
doaj   +2 more sources

The awesome lysosome

EMBO Molecular Medicine, 2016
In the early 50s, Christian De Duve identified a new cellular structure, the lysosome, defined as the cell's “suicide bag” (de Duve, 2005). Sixty years later, it is clear that the lysosome greatly exceeded the expectations of its discoverer.
Andrea Ballabio
doaj   +5 more sources

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.

PLoS ONE, 2021
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi, Evan Tang, Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena, Roberto J Botelho   +6 more
doaj   +1 more source

Reducing posttraumatic stress in parents of patients with a rare inherited metabolic disorder using eye movement desensitization and reprocessing therapy: a case study

Orphanet Journal of Rare Diseases, 2021
Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn, Lotte Haverman, Frits A. Wijburg, Carlijn De Roos   +3 more
doaj   +1 more source

Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

Scientific Reports, 2021
We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet, Brian Ritchey, Shuhui Wang Lorkowski, Alexander M. Alzayed, Sophia DeGeorgia, Eve Schodowski, C. Alicia Traughber, Jonathan D. Smith   +7 more
doaj   +1 more source

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Nature Communications, 2021
In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías   +9 more
doaj   +1 more source