Results 31 to 40 of about 222,748 (293)
Neuroscience Letters, 2019 Lysosomes support diverse cellular functions by acting as sites of macromolecule degradation and nutrient recycling. The degradative abilities of lysosomes are conferred by a lumen that is characterized by an acidic pH and which contains numerous hydrolases that support the breakdown of major cellular macromolecules to yield cellular building blocks ...
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Annual Review of Physiology, 2015 Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
Haoxing, Xu, Dejian, Ren
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Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2017 Lysosomes, the major membrane-bound degradative organelles, have a multitude of functions in eukaryotic cells. Lysosomes are the terminal compartments in the endocytic pathway, though they display highly dynamic behaviors, fusing with each other and with
Kevin Gee +11 more
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Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]
, 2018 Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina +11 more
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Journal of Inborn Errors of Metabolism and Screening, 2016 Since Christian de Duve first described the lysosome in the 1950s, it has been generally presented as a membrane-bound compartment containing acid hydrolases that enables the cell to degrade molecules without being digested by autolysis.
Ursula Matte BSc, PhD +1 more
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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants. [PDF]
PLoS ONE, 2014 Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing
Jürgen Brojatsch +6 more
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Programmed Cell Death and Postharvest Deterioration of Horticultural Produce [PDF]
, 2010 Programmed cell death (PCD) is a process where cells or tissues are broken down in an orderly and predictable manner, whereby nutrients are re-used by other cells, tissues or plant parts.
Iakimova, E.T., Woltering, E.J.
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Lysosome-mediated processing of chromatin in senescence [PDF]
, 2013 Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are
Adams +100 more
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Contact, 2022 Lysosomes serve as cellular degradation and signaling centers that coordinate the turnover of macromolecules with cell metabolism. The adaptation of cellular lysosome content and activity via the induction of lysosome biogenesis is therefore key to cell ...
Mouhannad Malek, Volker Haucke
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Nanodrugs Detonate Lysosome Bombs
Frontiers in Pharmacology, 2022 Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively ...
Yuting Xiang +20 more
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