Results 31 to 40 of about 180,932 (288)
Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
BMC Immunology, 2023 Purpose Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA ...
Guihong Chen +5 more
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Contact, 2022 Lysosomes serve as cellular degradation and signaling centers that coordinate the turnover of macromolecules with cell metabolism. The adaptation of cellular lysosome content and activity via the induction of lysosome biogenesis is therefore key to cell ...
Mouhannad Malek, Volker Haucke
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IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death.
A, Terman +3 more
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, 2018 Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward ...
Deliang Kong (382201) +19 more
core +1 more source
AIE materials for lysosome imaging
, 2021 The aggregation-induced emission (AIE) active bioprobes are known for their high photostability and extraordinary signal to noise ratio. In view of this, research efforts to synthesize new AIE bioimaging probes are at an incredible speed. In this chapter,
Manoj Kumar +5 more
core +1 more source
Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells
, 2016 Cathepsin B (CTB) is a lysosomal protease which has been recognized as a promising biomarker for many malignant tumors, and accurate detection of its activity is important in early diagnosis of cancers and predicting metastasis.
Jingfang Yu (1428361) +6 more
core +1 more source
, 2019 Lysosomal β-N-acetylhexosaminidase (Hex) has been reported to possess unique physiological performances. Detection and visualization of Hex in lysosome will be favorable to reveal the basis of its functions.
Guoyu Jiang (1708975) +15 more
core +1 more source
BMC Cancer, 2017 Background Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement
Samantha S. Dykes +2 more
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Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury
Kidney Diseases, 2021 Background: Macroautophagy (autophagy) is a cellular recycling process involving the destruction of damaged organelles and proteins in intracellular lysosomes for efficient nutrient reuse.
Xiao-cui Chen +5 more
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Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.
PLoS ONE, 2012 Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
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