The lysosome as a master regulator of iron metabolism.
TIBS -Trends in Biochemical Sciences. Regular ed, 2021 Intracellular iron fulfills crucial cellular processes, including DNA synthesis and mitochondrial metabolism, but also mediates ferroptosis, a regulated form of cell death driven by lipid-based reactive oxygen species (ROS). Beyond their established role
Francesca Rizzollo +3 more
semanticscholar +1 more source
Neurophysiological, behavioral and morphological abnormalities in the Fabry knockout mice
Neurobiology of Disease, 2009 Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the α-galactosidase gene (GLA). Loss of α-galactosidase (α-Gal) activity leads to the abnormal accumulation of glycosphingolipids in lysosomes predominantly of ...
L.G. Rodrigues +7 more
doaj +1 more source
mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival [PDF]
, 2015 Funding provided by: Wellcome Trust Technology Platform 097945/B/11/Z, MRC Next Generation Optical Microscopy MR/K015869/1, Medical Research Council, Division of Signal Transduction Therapy Unit (AstraZeneca, Boehringer‐Ingelheim, GlaxoSmithKline, Merck ...
Michael J Munson +12 more
core +1 more source
Imaging cellular trafficking processes in real time using lysosome targeted up-conversion nanoparticles [PDF]
, 2017 β-NaYF4:Yb,Gd up-conversion nanoparticles, UCNPs, surface functionalized with suitable targetting peptides function as nontoxic lysosome-specific imaging ...
Sreedharan, S. +14 more
core +1 more source
Alginate oligosaccharides can maintain activities of lysosomes under low pH condition
Scientific Reports, 2021 The objective of this study was to report that lysosome extracted from egg white could be used as a drug through oral administration for treating diseases by using pH sensitive alginate oligosaccharides.
Ra-Mi Park +4 more
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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion
Autophagy, 2018 Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation.
Mario Mauthe +9 more
semanticscholar +1 more source
Lysosome assembly and disassembly changes endocytosis rate through the Leishmania cell cycle
MicrobiologyOpen, 2020 The Leishmania lysosome has an atypical structure, consisting of an elongated vesicle‐filled tubule running along the anterior–posterior axis of the cell, which is termed the multivesicular tubule (MVT) lysosome.
Ziyin Wang +2 more
doaj +1 more source
The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei [PDF]
, 2015 Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and
Cynthia Y. He +7 more
core +1 more source
Journal of Inborn Errors of Metabolism and Screening, 2016 Since Christian de Duve first described the lysosome in the 1950s, it has been generally presented as a membrane-bound compartment containing acid hydrolases that enables the cell to degrade molecules without being digested by autolysis.
Ursula Matte BSc, PhD +1 more
doaj +1 more source
Ferroptosis Inhibition by Lysosome-Dependent Catabolism of Extracellular Protein
Cell Chemical Biology, 2022 SUMMARY Cancer cells must ensure a steady supply of nutrients to enable proliferation and evade cell death. Depriving cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of ferroptosis.
David A. Armenta +8 more
semanticscholar +1 more source