Results 51 to 60 of about 158,851 (164)

SNX8 enables lysosome reformation and reverses lysosomal storage disorder

Nature Communications
Lysosomal Storage Disorders (LSDs), which share common phenotypes, including enlarged lysosomes and defective lysosomal storage, are caused by mutations in lysosome-related genes.
Xinran Li, Cong Xiang, Shilei Zhu, Jiansheng Guo, Chang Liu, Ailian Wang, Jin Cao, Yan Lu, Dante Neculai, Pinglong Xu, Xin-Hua Feng   +10 more
doaj   +1 more source

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.

PLoS Pathogens
Mycobacterium tuberculosis (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized.
Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M Budzik, Beth Shoshana Zha, Zachary Howard, Lucas Chen, Joel D Ernst   +7 more
doaj   +1 more source

Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry

iScience, 2019
Summary: The invasion of a suitable host hepatocyte by Plasmodium sporozoites is an essential step in malaria infection. We demonstrate that in infected hepatocytes, lysosomes are redistributed away from the nucleus, and surface exposure of lysosome ...
Kamalakannan Vijayan, Igor Cestari, Fred D. Mast, Elizabeth K.K. Glennon, Suzanne M. McDermott, Heather S. Kain, Alyssa M. Brokaw, John D. Aitchison, Kenneth Stuart, Alexis Kaushansky   +9 more
doaj   +1 more source

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1.

PLoS Biology, 2023
The endoplasmic reticulum (ER) forms contacts with the lysosomal compartment, regulating lysosome positioning and motility. The movements of lysosomes are controlled by the attachment of molecular motors to their surface.
Alexandre Pierga, Raphaël Matusiak, Margaux Cauhapé, Julien Branchu, Lydia Danglot, Maxime Boutry, Frédéric Darios   +6 more
doaj   +1 more source

The mTOR–lysosome axis at the centre of ageing

FEBS Open Bio, 2022
Age‐related diseases represent some of the largest unmet clinical needs of our time. While treatment of specific disease‐related signs has had some success (for example, the effect of statin drugs on slowing progression of atherosclerosis), slowing ...
Julian M. Carosi, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant   +3 more
doaj   +1 more source

The attenuated end of the phenotypic spectrum in MPS III: from late-onset stable cognitive impairment to a non-neuronopathic phenotype

Orphanet Journal of Rare Diseases, 2019
Background The phenotypic spectrum of many rare disorders is much wider than previously considered. Mucopolysaccharidosis type III (Sanfilippo syndrome, MPS III), is a lysosomal storage disorder traditionally considered to be characterized by childhood ...
Stephanie C. M. Nijmeijer, L. Ingeborg van den Born, Anneke J. A. Kievit, Karolina M. Stepien, Janneke Langendonk, Jan Pieter Marchal, Susanne Roosing, Frits A. Wijburg, Margreet A. E. M. Wagenmakers   +8 more
doaj   +1 more source

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

Cell Reports, 2015
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase is ...
Lawrence D. Schweitzer, William C. Comb, Liron Bar-Peled, David M. Sabatini   +3 more
doaj   +1 more source

Lysosomes [PDF]

Current Biology, 2015
Wartosch, Lena, Bright, Nicholas A., Luzio, J. Paul   +2 more
openaire   +2 more sources

Tracking Lysosome Migration within Chinese Hamster Ovary (CHO) Cells Following Exposure to Nanosecond Pulsed Electric Fields

Bioengineering, 2018
Above a threshold electric field strength, 600 ns-duration pulsed electric field (nsPEF) exposure substantially porates and permeabilizes cellular plasma membranes in aqueous solution to many small ions.
Gary L. Thompson, Hope T. Beier, Bennett L. Ibey   +2 more
doaj   +1 more source

Peripheral positioning of lysosomes supports melanoma aggressiveness

Nature Communications
Emerging evidence suggests that the function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulation and secretion of proteases. Yet, how their function
Katerina Jerabkova-Roda, Marina Peralta, Kuang-Jing Huang, Antoine Mousson, Clara Bourgeat Maudru, Louis Bochler, Ignacio Busnelli, Rabia Karali, Hélène Justiniano, Lucian-Mihai Lisii, Philippe Carl, Vincent Mittelheisser, Nandini Asokan, Annabel Larnicol, Olivier Lefebvre, Hugo Lachuer, Angélique Pichot, Tristan Stemmelen, Anne Molitor, Léa Scheid, Quentin Frenger, Frédéric Gros, Aurélie Hirschler, François Delalande, Emilie Sick, Raphaël Carapito, Christine Carapito, Dan Lipsker, Kristine Schauer, Philippe Rondé, Vincent Hyenne, Jacky G. Goetz   +31 more
doaj   +1 more source