Results 51 to 60 of about 254,260 (291)

Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up in Situ Visualization of β‑N‑Acetylhexosaminidase

, 2019
Lysosomal β-N-acetylhexosaminidase (Hex) has been reported to possess unique physiological performances. Detection and visualization of Hex in lysosome will be favorable to reveal the basis of its functions.
Guoyu Jiang (1708975), Jianguo Wang (1400488), Dong Wang (73290), Jianguo Wang, Chunbin Li, Chunbin Li (6710477), Guoyu Jiang, Pengfei Zhang, Miaomiao Kang, Qingqing Chen, Pengfei Zhang (32384), Dong Wang, Qingqing Chen (490291), Qiang Wang (32383), Qiang Wang, Miaomiao Kang (5131274)   +15 more
core   +1 more source

Autophagosome-lysosome fusion.

Journal of Molecular Biology, 2020
Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during which selected cellular components are transported to and broken down within lysosomes.
P. Lőrincz, G. Juhász
semanticscholar   +1 more source

Phenylboronic Acid Modification Augments the Lysosome Escape and Antitumor Efficacy of a Cylindrical Polymer Brush-Based Prodrug.

Journal of the American Chemical Society, 2021
Timely lysosome escape is of paramount importance for endocytosed nanomedicines to avoid premature degradation under the acidic and hydrolytic conditions in lysosomes.
Ruo-Nan Wang, Changfeng Yin, Chang-Ren Liu, Ying Sun, P. Xiao, Jia Li, Shuo Yang, Wei Wu, Xi-Qun Jiang   +8 more
semanticscholar   +1 more source

Lysosome-Targeting Fluorogenic Probe for Cathepsin B Imaging in Living Cells

, 2016
Cathepsin B (CTB) is a lysosomal protease which has been recognized as a promising biomarker for many malignant tumors, and accurate detection of its activity is important in early diagnosis of cancers and predicting metastasis.
Jingfang Yu (1428361), Liandong Feng (3339192), Yuqi Wang (270190), Yan Zhang (8098), Jinbo Li (1333470), Deju Ye (1331409), Hong-Yuan Chen (1400701)   +6 more
core   +1 more source

Lysosome-Targeted Chemotherapeutics: Half-Sandwich Ruthenium(II) Complexes That Are Selectively Toxic to Cancer Cells

, 2018
Poor selectivity between cancer cells and normal cells is one of the major limitations of cancer chemotherapy. Lysosome-targeted ruthenium-based complexes target tumor cells selectively, only displaying rather weak cytotoxicity or inactivity toward ...
Deliang Kong (382201), Deliang Kong, Zhenzhen Tian, Yuliang Yang, Zhenzhen Tian (4821309), Junming Zhang (5446787), Zhishan Xu, Hairong Zhang, Zhe Liu, Shumiao Zhang (1496065), Yuliang Yang (1954498), Junming Zhang, Juanjuan Li, Juanjuan Li (399633), Zhe Liu (77240), Xingxing Ge, Zhishan Xu (5641997), Hairong Zhang (544828), Xingxing Ge (5642000), Shumiao Zhang   +19 more
core   +1 more source

The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.

Immunity
Induction of autophagy is an ancient function of the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway through which autophagic cargoes are delivered to lysosomes for degradation.
Yin-Feng Xu, Qian Wang, Jun Wang, Chu-Ying Qian, Yusha Wang, Sheng Lu, Li-Jiang Song, Zhengfu He, Wei Liu, Wei Wan   +9 more
semanticscholar   +1 more source

Direct lysosome-based autophagy of lipid droplets in hepatocytes

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Lipid droplets (LDs) are specialized fat-storage organelles that can be used as a fuel source by many types of cells when nutrients are scarce. One mechanism used by hepatocytes (the functional cells of the liver) for the catabolism of these
Ryan J. Schulze, E. Krueger, Shaun Weller, Katherine M. Johnson, C. Casey, Micah B. Schott, M. McNiven   +6 more
semanticscholar   +1 more source

Lysosomes and lysosome‐related organelles in immune responses

FEBS Open Bio, 2022
The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
C. Watts
semanticscholar   +1 more source

The role of lysosome in regulated necrosis

Acta Pharmaceutica Sinica B, 2020
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules, particles, and organelles. Currently, the pivotal role of lysosome in regulating cell death is drawing great attention.
Aqu Alu, Xuejiao Han, Xuelei Ma, Min Wu, Yuquan Wei, Xiawei Wei   +5 more
doaj   +1 more source

Nanodrugs Detonate Lysosome Bombs

Frontiers in Pharmacology, 2022
Cancer cell lysosomes contain various hydrolases and non-degraded substrates that are corrosive enough to destroy cancer cells. However, many traditional small molecule drugs targeting lysosomes have strong side effects because they cannot effectively ...
Yuting Xiang, Niansheng Li, Min Liu, Min Liu, Qiaohui Chen, Xingyu Long, Yuqi Yang, Yuqi Yang, Zuoxiu Xiao, Jia Huang, Jia Huang, Xiaoyuan Wang, Xiaoyuan Wang, Yunrong Yang, Yunrong Yang, Jinping Zhang, Jinping Zhang, Chong Liu, Chong Liu, Qiong Huang, Qiong Huang   +20 more
doaj   +1 more source