Results 61 to 70 of about 158,851 (164)

Beyond degradation: chemistry of lysosomal microenvironment in diseases and therapy

Chemical Physics Impact
Once viewed solely as a site for the degradation of biomolecules and damaged cell organelles, the lysosome is now recognised as a key organelle that links nutrient availability to cellular metabolism.
Shreeja Saha, Suman Sekhar Sahoo, Debasish Manna   +2 more
doaj   +1 more source

Lysosomes revisited [PDF]

European Journal of Biochemistry, 1983
The first international symposium on lysosomes [1] was held in 1963 at the Ciba Foundation, under the chairmanship of Danielli and with the participation of a prestigious membership. It is interesting to compare our present understanding of the properties and functions of lysosomes with what was known 20 years ago.
openaire   +2 more sources

Proteomics of the lysosome

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Defects in lysosomal function have been associated with numerous monogenic human diseases typically classified as lysosomal storage diseases. However, there is increasing evidence that lysosomal proteins are also involved in more widespread human diseases including cancer and Alzheimer disease.
Lübke, Torben, Lobel, Peter, Sleat, David E.   +2 more
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Lysosomes [PDF]

Nature Biotechnology, 2020
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Mitochondria acidify lysosomes through membrane contacts

Cell Reports
Summary: The acidic environment within the lysosome lumen is essential for its digestive function. However, the source of protons responsible for acidification has remained elusive.
Zhiqi Tian, Rui Chen, Guiqian Fang, Kangqiang Qiu, Weijun Wu, Xintian Shao, Daili Liu, Huilin Que, Xueqian Wang, Ji Gao, Jianyu Zhang, Bidyut Kundu, Qixin Chen, Jun-Lin Guan, Yueguang Rong, Ben Zhong Tang, Kai Li, Yujie Sun, Jiajie Diao   +18 more
doaj   +1 more source

The autophagy–lysosome pathway: a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

Neural Regeneration Research
Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in neurons.
Fengjuan Jiao, Lingyan Meng, Kang Du, Xuezhi Li   +3 more
doaj   +1 more source

Lysosome targeted therapies in hematological malignancies

Frontiers in Oncology
Lysosomes are dynamic organelles integral to cellular homeostasis, secretory pathways, immune responses, and cell death regulation. In cancers, lysosomes become dysregulated to sustain proliferative signaling, metabolism, and invasion.
Madhumita S. Manivannan, Anthea Peters, Spencer B. Gibson   +2 more
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Lysosomes

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Gieselmann, Volkmar, Braulke, Thomas
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Switching on lysosomes

eLife
The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
Deepak Adhikari, John Carroll
openaire   +3 more sources

TBC1D15-regulated mitochondria–lysosome membrane contact exerts neuroprotective effects by alleviating mitochondrial calcium overload in seizure

Scientific Reports
Mitochondrial calcium overload plays an important role in the neurological insults in seizure. The Rab7 GTPase-activating protein, Tre-2/Bub2/Cdc16 domain family member 15 (TBC1D15), is involved in the regulation of mitochondrial calcium dynamics by ...
Yinyin Xie, Wanwan Zhang, Tingting Peng, Xiaoyi Wang, Xiaolei Lian, Jiao He, Cui Wang, Nanchang Xie   +7 more
doaj   +1 more source