Results 61 to 70 of about 254,260 (291)
Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells
CellsIn eukaryotes, targeting intracellular components for lysosomal degradation by autophagy represents a catabolic process that evolutionarily regulates cellular homeostasis.
Po-Yuan Ke
semanticscholar +1 more source
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
bioRxiv, 2021 Mutations in VPS13C cause early onset, autosomal recessive Parkinson’s Disease (PD). We have established that VPS13C encodes a lipid transfer protein localized to contact sites between the endoplasmic reticulum (ER) and late endosomes/lysosomes.
William Hancock-Cerutti +8 more
semanticscholar +1 more source
BMC Cancer, 2017 Background Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement
Samantha S. Dykes +2 more
doaj +1 more source
Lysosome Depletion-Triggered Autophagy Impairment in Progressive Kidney Injury
Kidney Diseases, 2021 Background: Macroautophagy (autophagy) is a cellular recycling process involving the destruction of damaged organelles and proteins in intracellular lysosomes for efficient nutrient reuse.
Xiao-cui Chen +5 more
doaj +1 more source
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.
PLoS ONE, 2012 Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
doaj +1 more source
Cell Reports, 2018 Summary: Lysosome membrane recycling occurs at the end of the autophagic pathway and requires proteins that are mostly encoded by genes mutated in neurodegenerative diseases. However, its implication in neuronal death is still unclear. Here, we show that
Maxime Boutry +19 more
doaj +1 more source
PLoS Biology, 2021 The accumulation of α-synuclein (α-syn) aggregates in specific brain regions is a hallmark of synucleinopathies including Parkinson disease (PD). α-Syn aggregates propagate in a “prion-like” manner and can be transferred inside lysosomes to recipient ...
Aysegul Dilsizoglu Senol +10 more
semanticscholar +1 more source
, 2020 Nitric oxide (NO) and superoxide anions (O2•‑) are two noteworthy reactive species implicated in various physiological and pathological processes, such as ROS-induced lysosomal cell death.
Thomas W. Rees (4318561) +15 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nucleic Acid-driven Protein Degradation: Frontiers of Lysosomal Targeted Degradation Technology
Shengwu huaxue yu shengwu wuli jinzhanDistinct from the complementary inhibition mechanism through binding to the target with three-dimensional conformation of small molecule inhibitors, targeted protein degradation technology takes tremendous advantage of endogenous protein degradation ...
YIN Han +6 more
doaj +1 more source