Results 41 to 50 of about 158,851 (164)
Annual Review of Physiology, 2015 Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
Haoxing, Xu, Dejian, Ren
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Neural Regeneration Research, 2023 Millions of people are suffering from Alzheimer’s disease globally, but there is still no effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches for Alzheimer’s disease are needed, which requires further evaluation of ...
Wenlong Xue, Jie Zhang, Yang Li
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IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 The lysosomal compartment is the place for cellular degradation of endocytosed and autophagocytosed material and a center for normal turnover of organelles as well as most long-lived proteins. Lysosomes were long considered stable structures that broke and released their many hydrolytic enzymes only following necrotic cell death.
A, Terman +3 more
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Protein & Cell, 2018 Lysosomes are degradation and signaling centers within the cell, and their dysfunction impairs a wide variety of cellular processes. To understand the cellular effect of lysosome damage, we screened natural small-molecule compounds that induce lysosomal ...
Yang Li +13 more
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Heliyon, 2022 Lysosomal biogenesis is an essential adaptive process by which lysosomes exert their function in maintaining cellular homeostasis. Defects in lysosomal enzymes and functions lead to lysosome-related diseases, including lysosomal storage diseases and ...
Xiao Ding +11 more
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Heliyon, 2023 A new ent-abietane diterpenoid, named Euphejolkinolide A (1), was isolated from the whole plant of Euphorbia peplus L. Its structure, including absolute configurations, was determined by spectroscopic analyses and was corroborated by single-crystal X-ray
Xiaoqian Ran +12 more
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LAMP3 expression correlated with poor clinical outcome in human ovarian cancer
Tumor Biology, 2017 Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy.
Di Wang +6 more
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FLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1. [PDF]
PLoS ONE, 2016 The intracellular amino acid pool within lysosome is a signal that stimulates the nutrient-sensing mTORC1 signalling pathway. The signal transduction cascade has garnered much attention, but little is known about the sequestration of the signalling ...
Xiaochun Wu +6 more
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Neoplasia: An International Journal for Oncology Research, 2008 Noninvasive imaging of lysosomes will be useful 1) to elucidate the role of lysosomal parameters in cancer, 2) to diagnose malignant lesions, and 3) to evaluate future lysosome-targeted anticancer therapies.
Cong Li +2 more
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Scientific Reports, 2017 In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of aggregates have been proposed, including direct membrane penetration and endocytosis.
Peizhou Jiang +4 more
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