Results 41 to 50 of about 254,260 (291)
Autophagic lysosome reformation in health and disease
Autophagy, 2022 Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained.
Randini Nanayakkara +6 more
semanticscholar +1 more source
A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants. [PDF]
PLoS ONE, 2014 Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing
Jürgen Brojatsch +6 more
doaj +1 more source
Autophagy, 2021 The autophagy-lysosome system is an important cellular degradation pathway that recycles dysfunctional organelles and cytotoxic protein aggregates. A decline in this system is pathogenic in many human diseases including neurodegenerative disorders, fatty
Se-Jin Jeong +13 more
semanticscholar +1 more source
Autophagy, 2022 The acidic environment within lysosomes is maintained within a narrow pH range (pH 4.5-5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building block metabolites can be reused.
Mei-Qin Hu +3 more
semanticscholar +1 more source
Screening of four lysosome-related genes in sepsis based on RNA sequencing technology
BMC Immunology, 2023 Purpose Screening of lysosome-related genes in sepsis patients to provide direction for lysosome-targeted therapy. Methods Peripheral blood samples were obtained from 22 patients diagnosed with sepsis and 10 normal controls for the purpose of RNA ...
Guihong Chen +5 more
doaj +1 more source
Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Mitochondria and lysosomes are critical for cellular homeostasis and defects in both organelles are observed in several diseases. Recently, contact sites between mitochondria and lysosomes were identified and found to modulate mitochondrial ...
Wesley J Peng, Y. Wong, D. Krainc
semanticscholar +1 more source
RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
Nature Communications, 2022 The bidirectional movement of lysosomes on microtubule tracks regulates their whole-cell spatial arrangement. Arl8b, a small GTP-binding (G) protein, promotes lysosome anterograde trafficking mediated by kinesin-1.
G. Kumar +7 more
semanticscholar +1 more source
Contact, 2022 Lysosomes serve as cellular degradation and signaling centers that coordinate the turnover of macromolecules with cell metabolism. The adaptation of cellular lysosome content and activity via the induction of lysosome biogenesis is therefore key to cell ...
Mouhannad Malek, Volker Haucke
doaj +1 more source
Nature Cell BiologyBased on genetic studies, lysosome dysfunction is thought to play a pathogenetic role in Parkinson’s disease. Here we show that VPS13C, a bridge-like lipid-transport protein and a Parkinson’s disease gene, is a sensor of lysosome stress or damage ...
Xin-Bo Wang +11 more
semanticscholar +1 more source
New insights regarding SNARE proteins in autophagosome-lysosome fusion
Autophagy, 2020 Macroautophagy/autophagy refers to the engulfment of cellular contents selected for lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the lysosome, which is mediated by SNARE proteins.
Xiaoyu Tian, J. Teng, Jian-Guo Chen
semanticscholar +1 more source