Results 1 to 10 of about 484 (86)

Two-pore channel regulators - Who is in control? [PDF]

Frontiers in Physiology
Two-pore channels (TPCs) are adenine nucleotide and phosphoinositide regulated cation channels. NAADP activates and ATP blocks TPCs, while the endolysosomal phosphoinositide PI(3,5)P2 activates TPCs.
Christian Grimm, Marc Freichel
exaly   +4 more sources

Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking [PDF]

Cells
The endolysosomal system plays a pivotal role in cellular function. Before reaching lysosomes for degradation, the endocytosed cargoes are sorted at various stages of endosomal trafficking for recycling and/or rerouting.
Michael Zhu, Heng Zhang
exaly   +4 more sources

Fathers’ preconception smoking and offspring DNA methylation [PDF]

Clinical Epigenetics, 2023
Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited.
Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman, Francisco Gómez-Real, Vivi Schlünssen, Cecilie Svanes, John W. Holloway   +19 more
doaj   +2 more sources

The Three Two-Pore Channel Subtypes from Rabbit Exhibit Distinct Sensitivity to Phosphoinositides, Voltage, and Extracytosolic pH

Cells, 2022
Two pore channels (TPCs) are implicated in vesicle trafficking, virus infection, and autophagy regulation. As Na+- or Ca2+-permeable channels, TPCs have been reported to be activated by NAADP, PI(3,5)P2, and/or high voltage.
Jian Xiong, Xinghua Feng, Jinbin Tian
exaly   +3 more sources

Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account

Cells, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels.
Marchant Js, Sandip Patel, Christian Grimm   +2 more
exaly   +3 more sources

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca²⁺ Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium. [PDF]

Adv Sci (Weinh)
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H.   +8 more
europepmc   +2 more sources

DPCDI: an artificial intelligent-derived indicator interpreting the diagnostic, stratification, and therapeutic implications of druggability programmed cell death in heart failure [PDF]

Frontiers in Genetics
Programmed cell death (PCD) pathways with druggable potential represent a promising but still underexplored frontier in heart failure (HF) research for diagnosis, prognosis, and therapy. To address this gap, we developed a Druggable Programmed Cell Death
Lili Zhang, Yihao Zhu, Yuan Fang, Yanping Yang, Yin Yu, Hanshi Wang, Xiyue Jiang, Xue Zhang, Dong Huang   +8 more
doaj   +2 more sources

The Human-Specific miR-6762-5p Is an Activator of RhoA GTPase Enhancing Shigella flexneri Intercellular Spreading. [PDF]

Mol Microbiol
Proposed model in which human miR‐6762‐5p expression activates RhoA to promote Shigella flexneri dissemination: During the late phase of infection, miR‐6762‐5p is expressed from its host gene TPCN1. This leads to RhoA activation and thus stress fiber formation.
Reisacher C, Saifi E, Ageron E, Mallmann RT, Klugbauer N, Skurnik D, Arbibe L.   +6 more
europepmc   +2 more sources

A novel approach to resilience and its links with education and Alzheimer's disease genetics. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Cognitive resilience refers to maintaining cognitive function despite Alzheimer's disease (AD) pathophysiology. METHODS We analyzed amyloid‐positive individuals across clinical stages of AD in two cohorts: the Amsterdam Dementia Cohort (ADC, N = 1036) and Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 685).
Carrigan M, Bocancea DI, Vogel J, van Loenhoud AC, Tesi N, Barkhof F, Lucassen PJ, van der Flier WM, Krugers HJ, Van der Lee SJ, Ossenkoppele R.   +10 more
europepmc   +2 more sources

Lactobacillus johnsonii Generates Cyclo(pro-trp) and Promotes Intestinal Ca²⁺ Absorption to Alleviate CKD-SHPT. [PDF]

Adv Sci (Weinh)
The mechanism map of how L.johnsonii generates cyclo(pro‐trp) to alleviate CKD–SHPT by promoting the expression of CaSR and TRPV4 in IECs, enhancing Ca2+ absorption, and negatively feedback inhibiting iPTH secretion. Abstract Patients with chronic kidney disease (CKD) are at a high risk of developing secondary hyperparathyroidism (SHPT), which may ...
Zeng X, Sun L, Xie H, Gong S, Lu C, Xu Z, Guan H, Han B, Wang W, Zhang Z, Zhou J, Wang S, Chen Y, Xiao W.   +13 more
europepmc   +2 more sources