Results 21 to 30 of about 563 (109)

Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

Neurobiology of Disease, 2022
The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from individuals clinically diagnosed with “AD-type” (amnestic) dementia usually harbor ...
Yuriko Katsumata, Lincoln M. Shade, Timothy J. Hohman, Julie A. Schneider, David A. Bennett, Jose M. Farfel, Walter A. Kukull, David W. Fardo, Peter T. Nelson   +8 more
doaj   +1 more source

Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma

Frontiers in Immunology, 2021
BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene
Qian Zhang, Qian Zhang, Liping Lv, Liping Lv, Ping Ma, Ping Ma, Yangyang Zhang, Yangyang Zhang, Jiang Deng, Jiang Deng, Yanyu Zhang, Yanyu Zhang   +11 more
doaj   +1 more source

Cross-Study Meta-Analysis of Blood Transcriptomes in Type 2 Diabetes. [PDF]

Int J Mol Sci
Type 2 diabetes (T2D) is a chronic metabolic disorder with an estimated prevalence of over 422 million individuals affected globally. Since the advent of genomics, numerous studies have been conducted to elucidate T2D pathogenetic mechanisms and define ...
Tkachenko AA, Tonyan ZN, Nasykhova YA, Barbitoff YA, Renev IN, Danilova MM, Basipova AA, Glavnova OB, Polev DE, Chepanov SV, Selkov SA, Golovkin NV, Vlasova ME, Glotov AS.   +13 more
europepmc   +2 more sources

Localized TPC1-mediated Ca²⁺ release from endolysosomes contributes to myoseptal junction development in zebrafish

, 2022
In the trunk of developing zebrafish embryos, adjacent myotome blocks transmit contractile force via myoseptal junctions (MJs), which are dynamic structures that connect the actin cytoskeleton of skeletal muscle cells to extracellular matrix components ...
Rice, Keira L., Webb, Sarah E., Miller, Andrew L.   +2 more
core   +1 more source

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

Frontiers in Cell and Developmental Biology, 2020
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann, Melanie Bender, Dagmar Schumacher, Dagmar Schumacher, Marcel S. Woo, Artem Shaposhnykov, Sina C. Rosenkranz, Vladimir Kuryshev, Vladimir Kuryshev, Chris Meier, Andreas H. Guse, Manuel A. Friese, Marc Freichel, Marc Freichel, Volodymyr Tsvilovskyy, Volodymyr Tsvilovskyy   +15 more
doaj   +1 more source

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. [PDF]

, 2015
The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both
Lianne C Davis, John Parrington, Platt, Frances M., Biel, Martin, Powell, Trevor, Platt, Nick, Ruas Da Silva, Isabel M., Wahl-Schott, Wahl-Schott, Christian Wahl‐Schott, Anthony J Morgan, Clive Garnham, Cheng‐Chang Chen, Martin Biel, Antony Galione, Christian Grimm, Nick Platt, Walseth, Timothy F., Garnham, Clive, Morgan, Anthony J., Trevor Powell, Frances M Platt, Grimm, Christian, Margarida Ruas, Davis, Lianne C., Parrington, John, Chen, Cheng-Chang, Kai‐Ting Chuang, Chuang, Kai-Ting, Timothy F Walseth, Galione, Antony   +29 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

eLife, 2019
Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the
Xiaoli Zhang, Wei Chen, Ping Li, Raul Calvo, Noel Southall, Xin Hu, Melanie Bryant-Genevier, Xinghua Feng, Qi Geng, Chenlang Gao, Meimei Yang, Kaiyuan Tang, Marc Ferrer, Juan Jose Marugan, Haoxing Xu   +14 more
doaj   +1 more source

Using whole genome sequence findings to assess gene-disease causality in cardiomyopathy and arrhythmia patients supplementary material

, 2023
Aim: The genetic etiologies of cardiomyopathies and arrhythmias have not been fully elucidated. Materials & methods: Research findings from genome analyses in a cardiomyopathy and arrhythmia cohort were gathered.
Aishwarya Rajesh Krishnan (17143328), Cherith Somerville (12108475), Marci LB Schwartz (17143331), Qiliang Ding (17143333), Raymond H Kim (17143334)   +4 more
core   +1 more source

Increased human myocardial expression of Two-Pore Calcium channels TPCN1 and TPCN2 in heart failure as a whole (HF) and aetiological groups (ischaemic or dilated cardiomyopathy, ICM, DCM) and compared with non-diseased donors (CTL).

, 2013
A. Box-plot of TPCN1 and TPCN2 mRNA expression, showing for TPCN1 a significant increase over CTL (n = 6) for HF (n = 36, p = 0.018) and DCM (n = 20, p = 0.015); and for TPCN2 a significant increase over CTL (n = 6) for HF (n = 36, p = 0.001), ICM (n ...
Ana Mosquera-Leal (320200), Vanessa García-Rúa (320191), María Álvarez-Barredo (320199), Miguel Rivera (299169), Pamela Virginia Lear (320195), Manuel Portolés (299177), Josep Brugada (285270), Francisca Lago (293475), Manuel Francisco Otero (320193), Teresa Noguera-Moreno (320198), Sandra Feijóo-Bandín (320197), José Ramón González-Juanatey (239790), John Parrington (320201), Diego Rodríguez-Penas (320196), Manuel Calaza (134680)   +14 more
core   +1 more source