Results 41 to 50 of about 563 (109)

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

Exploration of the possible role(s) of two pore channel type 1 (TPC1)-mediated Ca²⁺ release during skeletal muscle development in zebrafish embryos

, 2022
In the trunk of developing zebrafish embryos, adjacent myotome blocks transmit contractile force via myoseptal junctions (MJs), dynamic structures that connect the actin cytoskeleton of skeletal muscle cells to extracellular matrix components via ...
Rice, Keira Lee
core  

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, Volume 24, Issue 6, June 2025.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Table_3_Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma.xlsx

, 2021
BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene
Ping Ma (15010), Yangyang Zhang (608493), Liping Lv (3160716), Yanyu Zhang (281806), Jiang Deng (1708582), Qian Zhang (49333)   +5 more
core   +1 more source

Conserved DNA methylation signatures in the prefrontal cortex of female newborn and juvenile guinea pigs following antenatal betamethasone exposure

Journal of Neuroendocrinology, Volume 37, Issue 4, April 2025.
Abstract Antenatal corticosteroids (ACS) improve perinatal survival when there is a risk of preterm birth. Although evidence suggests an increased risk of developing neurobehavioural disorders in exposed offspring, the mechanisms involved remain largely unknown.
Bona Kim, Alice Kostaki, Stephen G. Matthews   +2 more
wiley   +1 more source

Table_1_Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma.xlsx

, 2021
BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene
Ping Ma (15010), Yangyang Zhang (608493), Liping Lv (3160716), Yanyu Zhang (281806), Jiang Deng (1708582), Qian Zhang (49333)   +5 more
core   +1 more source

Mitochondrial dysfunction, cause or consequence in neurodegenerative diseases?

BioEssays, Volume 47, Issue 1, January 2025.
Endolysosomal and mitochondrial dysfunctions are major pathological hallmarks in neurodegeneration. In healthy neurons, lysosomes maintain mitochondrial health through membrane contact sites and local translation. In disease, failing lysosomal degradation compromises mitophagy, activating cGAS‐STING leading to further congestion and immune responses ...
Zoë P. Van Acker, Thomas Leroy, Wim Annaert   +2 more
wiley   +1 more source

P4-induced aberrant lysosomal function is rescued by TRPML1.

(A and B) PK-15 cells were infected with PRV HN1201 (MOI = 0.1) for 0–24 hours. The mRNA levels of TPCN1 (A) and TPCN2 (B) were analyzed by qRT-PCR. (C) PK-15 cells were treated as indicated in (A).
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
core   +1 more source

estudio proteómico en corazones de ratones deficientes en el canal iónico voltaje-dependiente TPCN1 [PDF]

, 2012
Comunicaciones a ...
Lear, Pamela, Lago Paz, Francisca, Alonso, Jana, García-Rúa, Vanesa, González-Juanatey, José Ramón   +4 more
core   +1 more source

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion [PDF]

, 2015
Ca2+ signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (GLP-1).
Rutter, GA, Parrington, J, Cane, MC, Rorsman, P, Galione, A   +4 more
core   +3 more sources