Results 31 to 40 of about 563 (109)

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function

, 2012
Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca2+) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown
Tunn, Ruth Elizabeth
core   +1 more source

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes [PDF]

, 2012
SummaryMammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second messenger, nicotinic acid adenine ...
Zhu, Michael X., Clapham, David E., Samie, Mohammad, Goschka, Andrew, Zhang, Xiaoli, Zhou, Yandong, Wang, Xiang, Harlow, Janice, Li, Xinran, Ren, Dejian, Shen, Dongbiao, Cheng, Xiping, Dong, Xian-ping, Xu, Haoxing   +13 more
core   +1 more source

Shared genes and pathways in dementia: Insights from genome‐wide association studies

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence. Genome‐wide association studies (GWASs), as highlighted in this review, have revolutionized our understanding of dementia by identifying contributing genetic loci and pathways,
Kyle J. Loi, Noah Radtke, Chloe Kiriluk, Mohamed H. Noureldein, Eva L. Feldman, Kelly M. Bakulski, Kevin S. Chen   +6 more
wiley   +1 more source

MtDNA‐depleted neuronal cell transcriptomes reveal Alzheimer's disease‐related changes

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION We determined whether mitochondrial DNA (mtDNA) depletion induced Alzheimer's disease (AD)‐relevant transcription changes. METHODS Following RNA sequencing (RNA‐seq), we identified differentially expressed genes (DEGs) between SH‐SY5Y or NT2 mtDNA‐depleted (ρ0) and intact (ρ+) cell lines and quantified concordant DEG changes. Gene
Blaise W. Menta, Emily Schueddig, Amol Ranjan, Yanming Li, Shea J. Andrews, Heather M. Wilkins, Dong Pei, Russell H. Swerdlow   +7 more
wiley   +1 more source

Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer's-type dementia. [PDF]

Acta Neuropathol
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid beta (Aβ) plaques, a wide range of co-morbid neuropathological features can be observed in AD brains.
Laureyssen C, Küçükali F, Van Dongen J, Gawor K, Tomé SO, Ronisz A, Otto M, von Arnim CAF, Van Damme P, Vandenberghe R, Thal DR, Sleegers K.   +11 more
europepmc   +2 more sources

Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co‐pathologies, and sex differences

Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.
Abstract The heterogeneity of Alzheimer's disease (AD) is multi‐dimensional, encompassing clinical features such as neuropsychiatric symptoms (NPS), rate of progression, age of onset, comorbidities, and neuropathological features such as co‐pathologies, and represents the diverse outcomes of manifold genetic and environmental risk determinants.
E. Keats Shwab, Gita A. Pathak, Joshua Harvey, Michael E. Belloy, Corinne E. Fischer, Michael W. Lutz, Sonja W. Scholz, Noah Cook, Danielle M. Reid, Jingchun Chen, Dylan X. Guan, Fabricio Oliveira, Lindsey I. Sinclair, Uzochukwu Imo, Byron Creese, Ornit Chiba‐Falek, Neuropsychiatric Syndromes Professional Interest Area Multiomics Work Group, Alzheimer's Association, International Society to Advance Alzheimer's Research and Treatment, Chicago, Illinois, USA   +21 more
wiley   +1 more source

DataSheet_1_Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma.docx

, 2021
BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene
Ping Ma (15010), Yangyang Zhang (608493), Liping Lv (3160716), Yanyu Zhang (281806), Jiang Deng (1708582), Qian Zhang (49333)   +5 more
core   +1 more source

Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies

Alzheimer's &Dementia, Volume 21, Issue 7, July 2025.
Abstract Dementia with Lewy bodies (DLB), a progressive neurodegenerative disease with heterogeneous clinical presentations, greatly impacts patients, caregivers, and society. Despite its frequency, diagnosing and treating DLB remains challenging. Advances in in vivo biomarker assays reflecting underlying pathology are improving disease identification,
Jennifer G. Goldman, Bradley F. Boeve, Douglas Galasko, John‐Paul Taylor, James E. Galvin, James B. Leverenz, Frederic Blanc, Glenda Halliday, Kejal Kantarci, Afina W. Lemstra, Iracema Leroi, Simon J. G. Lewis, Irene Litvan, Helen Medsger, John O'Brien, Sonja W. Scholz, Dag Aarsland, Manabu Ikeda, Ian McKeith, Angela Taylor   +19 more
wiley   +1 more source

Effect of aging on calcium signaling in C57Bl6J mouse cerebral arteries [PDF]

, 2013
In cerebral arteries, alterations of vascular reactivity have been observed but not well molecularly characterized. Therefore, we have hypothesized that cerebrovascular reactivity could be modified by aging via a modification of Ca²⁺ signaling in smooth ...
Georgeon-Chartier, Carole, Prévot, Anne, Morel, Jean-Luc, Menguy, Céline   +3 more
core   +1 more source

Table_2_Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma.xlsx

, 2021
BackgroundPancreatic adenocarcinoma (PAAD) spreads quickly and has a poor prognosis. Autophagy research on PAAD could reveal new biomarkers and targets for diagnosis and treatment.MethodsAutophagy-related genes were translated into autophagy-related gene
Ping Ma (15010), Yangyang Zhang (608493), Liping Lv (3160716), Yanyu Zhang (281806), Jiang Deng (1708582), Qian Zhang (49333)   +5 more
core   +1 more source