Results 1 to 10 of about 54 (41)
Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population [PDF]
PLoS ONE, 2016 The aim of this study was to determine whether TPCN2 genetic variants are associated with type 2 diabetes and to elucidate which variants in TPCN2 confer diabetes susceptibility in the Chinese population.The sample population included 384 patients with ...
Jialin Yang, Ning Zhang, Hui Zheng
exaly +5 more sources
The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores [PDF]
Pflugers Archiv European Journal of Physiology, 2009 Second messenger-induced Ca(2+)-release from intracellular stores plays a key role in a multitude of physiological processes. In addition to 1,4,5-inositol trisphosphate (IP(3)), Ca(2+), and cyclic ADP ribose (cADPR) that trigger Ca(2+)-release from the endoplasmatic reticulum (ER), nicotinic acid adenine dinucleotide phosphate (NAADP) has been ...
Hartmut Cuny +2 more
exaly +4 more sources
Study of the role of the new endolysosomal receptors two pore channels (TPCN1 and TPCN2) in human, mouse and rat heart [PDF]
European Heart Journal, 2013 Purpose: Mammalian two-pore channel proteins (TPCN1, TPCN2) are recently identified as ion channels in intracellular endosomes and lysosomes whose role at cardiac level is completely unknown. Our aim was to study the cardiac effect of knocking out TPCN1 in mice as well as studying the regulation of expression of cardiac TPCN1 and TPCN2 by ...
Sandra Feijóo-Bandín +1 more
exaly +4 more sources
Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+ Currents in Isolated Lysosomes [PDF]
Journal of Biological Chemistry, 2010 Two-pore channels (TPCNs) have been proposed to form lysosomal Ca(2+) release channels that are activated by nicotinic acid adenine dinucleotide phosphate. Here, we employ a glass chip-based method to record for the first time nicotinic acid adenine dinucleotide phosphate -dependent currents through a two-pore channel (TPCN2) from intact lysosomes.
Martin Biel +2 more
exaly +3 more sources
Contact (Thousand Oaks (Ventura County, Calif )), 2023 We have previously shown that in the developing trunk of zebrafish embryos, two-pore channel type 2 (TPC2)-mediated Ca 2+ release from endolysosomes plays a role in the formation of the skeletal slow muscle.
Ho Sarah E +2 more
exaly +2 more sources
Chinese Medical Journal, 2022 . Background:. Systemic lupus erythematosus (SLE) is a complex autoimmune disease, and the mechanism of SLE is yet to be fully elucidated. The aim of this study was to explore the role of two-pore segment channel 2 (TPCN2) in SLE pathogenesis.
Ruixing Yu, Yong Cui, Jun Shu
exaly +3 more sources
Cells, 2022 Two pore channels (TPCs) are implicated in vesicle trafficking, virus infection, and autophagy regulation. As Na+- or Ca2+-permeable channels, TPCs have been reported to be activated by NAADP, PI(3,5)P2, and/or high voltage.
Jian Xiong, Xinghua Feng, Jinbin Tian
exaly +3 more sources
Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account
Cells, 2022 Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels.
Marchant Js +2 more
exaly +3 more sources
A patient with TPCN2-related hypopigmentation and ocular phenotype
European Journal of Human GeneticsAbstract Pigmentation is orchestrated by hundreds of genes involved in cellular functions going from early developmental fate of pigment cells to melanin synthesis. The Two Pore Channel 2 (TPC2) a Ca2+ and Na+ channel acidifies melanosomal pH and thus inhibits pigmentation.
Claudio Plaisant +2 more
exaly +3 more sources
Two-pore channel regulators - Who is in control?
Frontiers in PhysiologyTwo-pore channels (TPCs) are adenine nucleotide and phosphoinositide regulated cation channels. NAADP activates and ATP blocks TPCs, while the endolysosomal phosphoinositide PI(3,5)P2 activates TPCs.
Christian Grimm, Marc Freichel
exaly +3 more sources