Results 21 to 30 of about 751 (109)

Pleiotropic and sex-specific effects of cancer GWAS SNPs on melanoma risk in the population architecture using genomics and epidemiology (PAGE) study. [PDF]

PLoS ONE, 2015
BackgroundSeveral regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide association studies were also ...
Jonathan M Kocarnik, S Lani Park, Jiali Han, Logan Dumitrescu, Iona Cheng, Lynne R Wilkens, Fredrick R Schumacher, Laurence Kolonel, Chris S Carlson, Dana C Crawford, Robert J Goodloe, Holli H Dilks, Paxton Baker, Danielle Richardson, Tara C Matise, José Luis Ambite, Fengju Song, Abrar A Qureshi, Mingfeng Zhang, David Duggan, Carolyn Hutter, Lucia Hindorff, William S Bush, Charles Kooperberg, Loic Le Marchand, Ulrike Peters   +25 more
doaj   +2 more sources

Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking [PDF]

Cells
The endolysosomal system plays a pivotal role in cellular function. Before reaching lysosomes for degradation, the endocytosed cargoes are sorted at various stages of endosomal trafficking for recycling and/or rerouting.
Heng Zhang, Michael X. Zhu
doaj   +2 more sources

Targeting the two-pore channel 2 in cancer progression and metastasis

Exploration of Targeted Anti-tumor Therapy, 2022
The importance of Ca2+ signaling, and particularly Ca2+ channels, in key events of cancer cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently begun to be appreciated.
Kathryn A. Skelding, Daniel L. Barry, Danielle Z. Theron, Lisa F. Lincz   +3 more
doaj   +1 more source

Identification and Validation of Angiogenesis-Related Gene Expression for Predicting Prognosis in Patients With Ovarian Cancer

Frontiers in Oncology, 2022
Ovarian cancer (OC) is a highly heterogeneous disease with different cellular origins reported; thus, precise prognostic strategies and effective new therapies are urgently needed for patients with OC.
Yue Wang, Bao Xuan Li, Xiang Li
doaj   +1 more source

The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion [PDF]

, 2015
Ca2+ signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (GLP-1).
Rutter, GA, Parrington, J, Cane, MC, Rorsman, P, Galione, A   +4 more
core   +3 more sources

Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing

Human Genomics, 2022
Bicuspid aortic valve (BAV) is the most common congenital heart defect in human beings, with an estimated prevalence in the general population of between 0.5 and 2%.
Shasha Chen, Qinchun Jin, Shiqiang Hou, Mingfei Li, Yuan Zhang, Lihua Guan, Wenzhi Pan, Junbo Ge, Daxin Zhou   +8 more
doaj   +1 more source

NRG1 fusions in breast cancer

Breast Cancer Research, 2021
Background NRG1 gene fusions may be clinically actionable, since cancers carrying the fusion transcripts can be sensitive to tyrosine kinase inhibitors.
Karen D. Howarth, Tashfina Mirza, Susanna L. Cooke, Suet-Feung Chin, Jessica C. Pole, Ernest Turro, Matthew D. Eldridge, Raquel Manzano Garcia, Oscar M. Rueda, Chris Boursnell, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards   +12 more
doaj   +1 more source

Two pore channels (TPC2s) and nicotinic acid adenine dinucleotide phosphate (NAADP) at lysosomal-sarcoplasmic reticular junctions contribute to acute and chronic β-adrenoceptor signaling in the heart [PDF]

, 2015
Ca2+-permeable type 2 two-pore channels (TPC2) are lysosomal proteins required for nicotinic acid adenine dinucleotide phosphate (NAADP)-evoked Ca2+ release in many diverse cell types.
Shade, K-T, Bolton, Emma L., Shade, KT, Wang, Xin, Lei, M, Liu, W, Liu, W; id_orcid, Capel, Rebecca, Lei, Ming, Lin, WK, Burton, R-AB, Ruas, M, Bolton, EL, Parrington, J, Shade, Kai-Ting, Wang, X, Terrar, Derek A., Wang, Y, Burton, RB, Burton, Rebecca-Ann B., Liu, Wei, Churchill, Grant C., Capel, RA, Lin, Wee K., Bloor-Young, Duncan, Parrington, John, Ruas, Margarida, Wang, Yanwen, Churchill, GC, Aston, Daniel, Aston, D, Terrar, DA, Bloor-Young, D, Galione, A, Galione, Antony   +34 more
core   +1 more source

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons

Frontiers in Cell and Developmental Biology, 2020
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann, Melanie Bender, Dagmar Schumacher, Dagmar Schumacher, Marcel S. Woo, Artem Shaposhnykov, Sina C. Rosenkranz, Vladimir Kuryshev, Vladimir Kuryshev, Chris Meier, Andreas H. Guse, Manuel A. Friese, Marc Freichel, Marc Freichel, Volodymyr Tsvilovskyy, Volodymyr Tsvilovskyy   +15 more
doaj   +1 more source

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

eLife, 2019
Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the
Xiaoli Zhang, Wei Chen, Ping Li, Raul Calvo, Noel Southall, Xin Hu, Melanie Bryant-Genevier, Xinghua Feng, Qi Geng, Chenlang Gao, Meimei Yang, Kaiyuan Tang, Marc Ferrer, Juan Jose Marugan, Haoxing Xu   +14 more
doaj   +1 more source