Results 31 to 40 of about 751 (109)

Allele frequencies of TPCN2 polymorphisms.

, 2016
Allele frequencies of TPCN2 polymorphisms.
Ning Zhang (23771), Jialin Yang (2504542), Jiayi Shen (1679533), Yu Zhang (12946), Hui Zheng (58412), Yujuan Fan (2504536), Yuping Song (2504545), Xuesong Li (291235), Xiaofang Fan (458425), Chunfang Shen (2504539), Fengdong Ren (2504548)   +10 more
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Study of the roles of two pore channels (TPCs) in metabolism [PDF]

, 2023
Second messengers play roles in communication between and within cells and are critical in various physiological functions at cellular level. As an important second messenger, Ca2+, through spatiotemporal changes in its cytosolic concentration in the ...
Zhang, Yuxuan
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Genotype distributions of the TPCN2 rs3829241, rs1551305 and rs3750965 polymorphisms in controls and T2DM patients.

, 2016
Genotype distributions of the TPCN2 rs3829241, rs1551305 and rs3750965 polymorphisms in controls and T2DM patients.
Ning Zhang (23771), Jialin Yang (2504542), Jiayi Shen (1679533), Yu Zhang (12946), Hui Zheng (58412), Yujuan Fan (2504536), Yuping Song (2504545), Xuesong Li (291235), Xiaofang Fan (458425), Chunfang Shen (2504539), Fengdong Ren (2504548)   +10 more
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Increased human myocardial expression of Two-Pore Calcium channels TPCN1 and TPCN2 in heart failure as a whole (HF) and aetiological groups (ischaemic or dilated cardiomyopathy, ICM, DCM) and compared with non-diseased donors (CTL).

, 2013
A. Box-plot of TPCN1 and TPCN2 mRNA expression, showing for TPCN1 a significant increase over CTL (n = 6) for HF (n = 36, p = 0.018) and DCM (n = 20, p = 0.015); and for TPCN2 a significant increase over CTL (n = 6) for HF (n = 36, p = 0.001), ICM (n ...
Ana Mosquera-Leal (320200), Vanessa García-Rúa (320191), María Álvarez-Barredo (320199), Miguel Rivera (299169), Pamela Virginia Lear (320195), Manuel Portolés (299177), Josep Brugada (285270), Francisca Lago (293475), Manuel Francisco Otero (320193), Teresa Noguera-Moreno (320198), Sandra Feijóo-Bandín (320197), José Ramón González-Juanatey (239790), John Parrington (320201), Diego Rodríguez-Penas (320196), Manuel Calaza (134680)   +14 more
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Two newly identified genetic determinants of pigmentation in Europeans. [PDF]

, 2008
Contains fulltext : 70561.pdf (Publisher’s version ) (Open Access)We present results from a genome-wide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in
Vermeulen, Sita H, Sita H Vermeulen, Thorleifsson, Gudmar, Agnar Helgason, Gudbjartsson, D.F., Aben, Katja K, Snæbjörn Pálsson, Sulem, P., Stacey, S.N., Stacy Steinberg, Lambertus A Kiemeney, Kiemeney, L.A.L.M., Olafsson, Jon H, Tucker, Margaret A, Rafnar, Thorunn, Jakobsdottir, Margret, Augustine Kong, Gudjonsson, S.A., Kristin Thorisdottir, Steinberg, S., Vermeulen, H.H.M., Pálsson, Snaebjörn, Margret Jakobsdottir, Gudmar Thorleifsson, Rafn Ragnarsson, Palsson, S., Sigurgeirsson, B., Margaret A Tucker, Stefansson, Kari, Gulcher, Jeffrey, Goldstein, Alisa M, Gulcher, J.R., Ragnarsson, R., Sigurjon A Gudjonsson, Katja K Aben, Sigurgeirsson, Bardur, Benediktsdottir, K.R., Olafsson, J.H., Kristrun R Benediktsdottir, Goldstein, A.M., Stacey, Simon N, Palsson, Arnar, Thorisdottir, Kristin, Thorsteinsdottir, Unnur, Patrick Sulem, Tucker, M.A., Bardur Sigurgeirsson, Jon H Olafsson, Steinberg, Stacy, Thorisdottir, K., Daniel F Gudbjartsson, Simon N Stacey, Gudbjartsson, Daniel F, Thorsteinsdottir, U., Benediktsdottir, Kristrun R, Stefansson, K., Thorunn Rafnar, Kong, Augustine, Aben, K.K.H., Jeffrey Gulcher, Ragnarsson, Rafn, Helgason, Agnar, Alisa M Goldstein, Sulem, Patrick, Helgason, A., Rafnar, T., Kari Stefansson, Arnar Palsson, Palsson, A., Thorleifsson, G., Gudjonsson, Sigurjon A, Jakobsdottir, M., Kiemeney, Lambertus A, Kong, A., Unnur Thorsteinsdottir   +74 more
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Key players inducing skin diseases and skin aging and potential preventive or therapeutic strategies using phytochemicals

Journal of Dermatologic Science and Cosmetic Technology
Skin, the largest organ in the human body, consists of three distinct layers and is a barrier against hazardous environmental exposures to safeguard overall body health. While the superficial layers of skin and their appendages, like hair, are constantly
Hamid Mostafavi Abdolmaleky, Jinrong Zhou   +1 more
doaj   +1 more source

Deciphering the role of endolysosomal Ca2+ signalling via two-pore channel 2 (TPC2) in cancer: from bench to bedside

, 2023
Cancer is a major public health problem and one of the leading causes of death worldwide, necessitating the development of innovative cancer biomarkers/targets to improve detection, diagnosis, prognosis, and therapy.
Alharbi, Abeer
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Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function

, 2012
Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca2+) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown
Tunn, Ruth Elizabeth
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Exome-wide association study identifies four novel loci for systemic lupus erythematosus in Han Chinese population

, 2017
ObjectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease of considerable genetic predisposition. Genome-wide association studies have identified tens of common variants for SLE.
Xiaodong Zheng, Yi Zhou, Shengxiu Liu, Caihong Zhu, Yaohua Zhang, Min Gao, Tamilselvi Elango, Zaixing Wang, Zhanguo Li, Yuanjia Tang, Liangdan Sun, Nan Shen, Fengli Xiao, Chao Yang, Ke Xue, Xing Fan, Gang Chen, Peiguang Wang, Anping Zhang, Anjana Kafle, Jinhua Xu, Zhengwei Zhu, Fusheng Zhou, Huayang Tang, Yuyan Cheng, Xueqing Yu, Jingying Sun, Xianyong Yin, Lili Tang, Xianbo Zuo, Yong Cui, Yujun Sheng, Pan Li, Yantao Ding, Feng Li, Lu Liu, Jinping Gao, Ruixing Yu, Xuan Zhang, Bo Liang, Jun Zhu, Leilei Wen, Meng Wang, Xuejun Zhang, Jianping Guo, Chen Zhou, Sen Yang   +46 more
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Ca(2+) release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos

, 2017
We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca(2+) release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino ...
Webb, SE, Miller, AL, Parrington, J, Kelu, JJ, Galione, A   +4 more
core   +2 more sources