Results 41 to 50 of about 751 (109)

Mechanism of action and functional role of the two-pore channels (TPCs) in key vertebrate physiological processes [PDF]

, 2016
Two-pore channels (TPCs) represent a strong candidate for being pivotal components of the endolysosomal cation channels regulated by nicotinic acid adenine dinucleotide phosphate (NAADP), a novel Ca2+-releasing second messenger.
Chan, Lai Hing
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VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel 2-dependent Ca2+ signaling

, 2014
Vascular endothelial growth factor (VEGF) and its receptors VEGFR1/VEGFR2 play major roles in controlling angiogenesis, including vascularization of solid tumors. Here we describe a specific Ca(2+) signaling pathway linked to the VEGFR2 receptor subtype,
D. Del Bufalo, J. Parrington, GAMBARA, Guido, A. Galione, A. D'Alessio, FAVIA, ANNARITA, M. Desideri, FILIPPINI, Antonio, ESPOSITO, BIANCA, D'Alessio, Alessio, ZIPARO, Elio, PALOMBI, Fioretta, M. Ruas   +12 more
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TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes [PDF]

, 2012
SummaryMammalian two-pore channel proteins (TPC1, TPC2; TPCN1, TPCN2) encode ion channels in intracellular endosomes and lysosomes and were proposed to mediate endolysosomal calcium release triggered by the second messenger, nicotinic acid adenine ...
Zhu, Michael X., Clapham, David E., Samie, Mohammad, Goschka, Andrew, Zhang, Xiaoli, Zhou, Yandong, Wang, Xiang, Harlow, Janice, Li, Xinran, Ren, Dejian, Shen, Dongbiao, Cheng, Xiping, Dong, Xian-ping, Xu, Haoxing   +13 more
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Additional file 1 of Evidence for widespread existence of functional novel and non-canonical human transcripts

, 2023
Additional file 1: Figures S1-S12. Fig. S1. Pipeline of sequencing library construction and bioinformatics analysis. Fig. S2. Ratio of real vs simulated SICER clusters and CACFs based on 100 simulations in the 4 phenotypic assay systems. Fig.
Junjun Zhou (10793226), Lu Tang (655389), Fang Wang (105926), Philipp Kapranov (10836780), Dongyang Xu (17449663), Yu Huang (15093), Huifen Cao (507731)   +6 more
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Intersection of differentially expressed (GEX), separated in up-regulated (UP) and down-regulated (DW), and DMRs-neighboring (MBD) genes.

, 2013
At FDR 5% only 15 genes (hypergeometric probability = 0.69) are found in both lists, of which 6 were down-regulated (Dym, Glrx2, Mlph, Myh10, Pftk1, And Prep) and 9 up-regulated (Abcc8, Abhd6, Cep350, Ctsa, Eif2b3, Pdk1, Serpina11, Tpcn2, And Tyw3).
Elia Stupka (23015), Irina G. Bogdarina (504027), Adrian J. L. Clark (367055), Gioia Altobelli (504026), Simon Langley-Evans (367053)   +4 more
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Investigating the Role of Two-Pore Channel 2 (TPC2) in Zebrafish Neuromuscular Development

, 2020
In this chapter, the authors discuss the techniques used when investigating the role of Two-Pore Channel 2 (TPC2) in zebrafish neuromuscular development.
Sarah E. Webb, Jeffrey J. Kelu, Andrew L. Miller, Webb, Sarah Elizabeth, Kelu, Jeffrey Jenkin, Miller, Andrew Leitch   +5 more
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P4-induced aberrant lysosomal function is rescued by TRPML1.

(A and B) PK-15 cells were infected with PRV HN1201 (MOI = 0.1) for 0–24 hours. The mRNA levels of TPCN1 (A) and TPCN2 (B) were analyzed by qRT-PCR. (C) PK-15 cells were treated as indicated in (A).
Guo-Yu Yang (1728175), Bei-Bei Chu (8617002), Bing-Qian Su (8616981), Jiang Wang (14683), Sheng-Li Ming (8616975)   +4 more
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Association between SNPs in the TPCN2/MYEOV region and melanoma.

, 2015
3a) Association between SNP rs12418451 melanoma, both overall and stratified by sex.3b) Four additional SNPs within the same locus as rs12418451, shown for comparison (r2 with rs12418451 < 0.13 in 1000G CEU).Association between SNPs in the TPCN2/MYEOV ...
Charles Kooperberg (18693), Loic Le Marchand (89925), Holli H. Dilks (572402), Danielle Richardson (496182), Robert J. Goodloe (705984), Logan Dumitrescu (169202), Jonathan M. Kocarnik (531199), Fengju Song (405671), Abrar A. Qureshi (211789), Tara C. Matise (102194), David Duggan (108150), William S. Bush (107449), Lynne R. Wilkens (141315), Paxton Baker (705985), Lucia Hindorff (705987), Ulrike Peters (101963), S. Lani Park (705983), Chris S. Carlson (169211), Laurence Kolonel (23599), Dana C. Crawford (102216), Jiali Han (152479), Carolyn Hutter (705986), Iona Cheng (85330), Fredrick R. Schumacher (169233), José Luis Ambite (5662645), Mingfeng Zhang (211774)   +25 more
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Two-Pore Channel 2 activity is required for slow muscle cell-generated Ca2+ signaling during myogenesis in intact zebrafish

, 2015
We have recently characterized essential inositol 1,4,5-trisphosphate receptor (IP3R) and ryanodine receptor (RyR)-mediated Ca2+ signals generated during the differentiation of slow muscle cells (SMCs) in intact zebrafish embryos.
Jeffrey J. Kelu, Hayley L.H. Chan, John Parrington, Margarida Ruas, Kelu, Jeffrey J., Miller, Andrew L., Arthur H.H. Cheng, Parrington, John, Sarah E. Webb, Ruas, Margarida, Chan, Hayley L.H., Antony Galione, Webb, Sarah E., Andrew L. Miller, Cheng, Arthur H.H., Galione, Antony   +15 more
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Combination effects of distinct cores in 11q13 amplification region on cervical lymph node metastasis of oral squamous cell carcinoma

, 2011
Lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC) is known to associate with a significant decrease of 5-year survival. Genetic factors related to the difference of the LNM status in the OSCC have been not fully elucidated.
Michikawa, Yuichi, 478057, 478056, 478059, Imai, Takashi, 478058, 岩川 眞由美, Sugahara, Keisuke, 柴原 孝彦, 478068, 今井 高志, 478067, Shibahara, Takahiko, 478069, 478064, 478063, 478066, 478065, 荘司 好美, 478060, 478062, 菅原 圭亮, 石川 顕一, Iwakawa, Mayumi, 478061, 道川 祐市, Ishikawa, Kenichi, Shoji, Yoshimi   +27 more
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