Results 51 to 60 of about 751 (109)

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. [PDF]

, 2015
The second messenger NAADP triggers Ca2+ release from endo‐lysosomes. Although two‐pore channels (TPCs) have been proposed to be regulated by NAADP, recent studies have challenged this. By generating the first mouse line with demonstrable absence of both
Lianne C Davis, John Parrington, Platt, Frances M., Biel, Martin, Powell, Trevor, Platt, Nick, Ruas Da Silva, Isabel M., Wahl-Schott, Wahl-Schott, Christian Wahl‐Schott, Anthony J Morgan, Clive Garnham, Cheng‐Chang Chen, Martin Biel, Antony Galione, Christian Grimm, Nick Platt, Walseth, Timothy F., Garnham, Clive, Morgan, Anthony J., Trevor Powell, Frances M Platt, Grimm, Christian, Margarida Ruas, Davis, Lianne C., Parrington, John, Chen, Cheng-Chang, Kai‐Ting Chuang, Chuang, Kai-Ting, Timothy F Walseth, Galione, Antony   +29 more
core   +1 more source

A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable [PDF]

, 2013
Knowledge of markers in the human genome which show spatial patterns and display extreme correlation with different environmental determinants play an important role in understanding the factors which affect the biological evolution of our species.
Gasparini, Mauro, Matullo, G., Piazza, A., Di Gaetano C., Piazza A., Di Gaetano, C., Ursino, Moreno, Matullo G.   +7 more
core   +1 more source

TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle.

, 2010
Agonists such as those acting at muscarinic receptors are thought to induce contraction of smooth muscle primarily through inositol 1,4,5-trisphosphate production and release of Ca(2+) from sarcoplasmic reticulum.
John Parrington, Kai-Ting Chuang, Chuang, KT, Brading, A, Margarida Ruas, Durlu-Kandilci, NEZAHAT TUĞBA, Tugba Durlu-Kandilci, N, Parrington, John, Ruas, Margarida, Ruas, M, Tugba Durlu-Kandilci, Nezahat, Antony Galione, Parrington, J, Chuang, Kai-Ting, Brading, Alison, Nezahat Tugba Durlu-Kandilci, Alison Brading, Galione, A, Galione, Antony   +18 more
core   +1 more source

Whole genome-wide screening of cervical lymph node metastasis-associated genetic alterations in oral squamous cell carcinoma of Japanese patients

, 2007
To precisely identify genetic markers that reflect occurrence of cervical lymph node metastasis (LNM) in Japanese oral squamous cell carcinoma (OSCC) patients, oligonucleotide array-based comparative genomic hybridization (CGH) with individual gene-level
Michikawa, Yuichi, Imai, Takashi, 岩川 眞由美, Sugahara, Keisuke, Ootsuka, Yoshimi, 678128, 678129, 柴原 孝彦, 678130, 678137, 678138, 678135, 678136, 678133, 678134, 678131, 678132, 今井 高志, Shibahara, Takahiko, 678139, 荘司 好美, 菅原 圭亮, 石川 顕一, Iwakawa, Mayumi, 道川 祐市, Ishikawa, Kenichi, 678140, 678141   +27 more
core  

Investigating the role of two-pore channel type 2 (TPC2)-mediated Ca²⁺ release in regulating axonal extension of caudal primary neurons during zebrafish development

, 2020
The role of TPC2-mediated Ca2+ release was recently characterized in zebrafish during the establishment of the early spinal circuitry, one of the key events in the coordination of neuromuscular activity. Here, I extended the study to investigate the role
Guo, Chenxi
core  

Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD? [PDF]

Autophagy, 2023
Giuliano S, Montemagno C, Domdom MA, Teisseire M, Brest P, Klionsky DJ, Hofman P, Pagès G, Mograbi B.   +8 more
europepmc   +1 more source

Increased expression of fatty-acid and calcium metabolism genes in failing human heart.

Background Heart failure (HF) involves alterations in metabolism, but little is known about cardiomyopathy-(CM)-specific or diabetes-independent alterations in gene expression of proteins involved in fatty-acid (FA) uptake and oxidation or in calcium ...
Portolés, Manuel, García Rúa, Vanessa, Rivera, Miguel, Brugada Terradellas, Josep, 1958-, Noguera Moreno, Teresa, Feijóo Bandín, Sandra, Francisco Otero, Manuel, Lear, Pamela Virginia, Mosquera Leal, Ana, Parrington, John, Calaza, Manuel, Rodríguez Penas, Diego, González-Juanatey, José R., Lago, Francisca, Álvarez Barredo, María   +14 more
core  

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. [PDF]

Autophagy, 2022
Tong BC, Wu AJ, Huang AS, Dong R, Malampati S, Iyaswamy A, Krishnamoorthi S, Sreenivasmurthy SG, Zhu Z, Su C, Liu J, Song J, Lu JH, Tan J, Pan W, Li M, Cheung KH.   +16 more
europepmc   +1 more source

Distinct microglia alternative splicing in Alzheimer's disease. [PDF]

Aging (Albany NY), 2022
Lu Y, Tan L, Xie J, Cheng L, Wang X.
europepmc   +1 more source

Endosomal TPC1-mediated Ca²⁺ nanodomains regulate transferrin receptor trafficking and iron homeostasis. [PDF]

Proc Natl Acad Sci U S A
Burton WJ, Lin A, Morgan AJ, Davis LC, Chen CC, Galione A.   +5 more
europepmc   +1 more source