Results 21 to 30 of about 1,793 (129)
Biological Research, 2004 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems.
EDUARDO NUNES CHINI
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NAADP Mediates Insulin-Stimulated Glucose Uptake and Insulin Sensitization by PPARγ in Adipocytes
Cell Reports, 2012 Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity.
Eun-Kyung Song +10 more
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Contribution of NAADP to Glutamate-Evoked Changes in Ca2+ Homeostasis in Mouse Hippocampal Neurons
Frontiers in Cell and Developmental Biology, 2020 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that evokes calcium release from intracellular organelles by the engagement of calcium release channels, including members of the Transient Receptor Potential (TRP) family, such ...
Julia Hermann +15 more
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Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals
Scientific Reports, 2021 Pancreatic β-cells release insulin upon a rise in blood glucose. The precise mechanisms of stimulus-secretion coupling, and its failure in Diabetes Mellitus Type 2, remain to be elucidated.
Paula Maria Heister +2 more
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Electrophysiology of Endolysosomal Two-Pore Channels: A Current Account
Cells, 2022 Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels.
Sandip Patel +7 more
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Brazilian Journal of Medical and Biological Research, 2002 Cells possess multiple intracellular Ca2+-releasing systems. Sea urchin egg homogenates are a well-established model to study intracellular Ca2+ release. In the present study the mechanism of interaction between three intracellular Ca2+ pools, namely the
E.N. Chini
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Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells. [PDF]
PLoS ONE, 2013 Nicotinic acid adenine dinucleotide phosphate (NAADP) is an endogenous Ca(2+) mobilizing nucleotide presented in various species. NAADP mobilizes Ca(2+) from acidic organelles through two pore channel 2 (TPC2) in many cell types and it has been ...
Zhe-Hao Zhang, Ying-Ying Lu, Jianbo Yue
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Influence of NAADP and bafilomycine A1 on activity of ATPase in liver postmitochondrial fraction
Біологічні студії, 2015 Recycling of the endo-lysosomal organelles occur by permanent in the cell. This store is thought to be the acidic store because V-type of H+-ATPase is responsible for their acidification.
S. Bychkova
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Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Nature Communications, 2022 TPC2 is a lysosomal ion channel permeable to both calcium and sodium ions. Here, the authors show that TPC2 can selectively increase its calcium permeability when simultaneously challenged by both its natural activators- NAADP and PI(3,5)P2.
Yu Yuan +15 more
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Cells, 2023 Nicotinamide adenine dinucleotide (NAD) and its 2′-phosphorylated cousin NADP are precursors for the enzymatic formation of the Ca2+-mobilizing second messengers adenosine diphosphoribose (ADPR), 2′-deoxy-ADPR, cyclic ADPR, and nicotinic acid adenine ...
Andreas H. Guse
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