Results 41 to 50 of about 1,793 (129)

Copper-induced activation of TRPs and VDCCs triggers a calcium signature response regulating gene expression in Ectocarpus siliculosus [PDF]

PeerJ, 2018
In certain multicellular photoautotrophs, such as plants and green macroalgae, it has been demonstrated that calcium signaling importantly mediates tolerance to copper excess.
Alberto González, Claudio A. Sáez, Alejandra Moenne   +2 more
doaj   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Shennong 1 Chicken 40K Liquid Chip: Advancing Genetic Research in Chinese Indigenous Chickens

Animal Research and One Health, Volume 3, Issue 4, Page 405-419, November 2025.
Based on comprehensive genomic data of Chinese indigenous chickens, we developed a specialized genotyping array for this population. Comparative analyses with published mainstream arrays and evaluations, including genetic assessment of diverse chicken types and gene mining analyses, demonstrated its superior applicability to Chinese indigenous chickens.
Chaoqun Gao, Chenxi Zhang, Kaiyuan Tian, Shucan Zhao, Yongle Xue, Sensen Yan, Chengpeng Xiao, Donghua Li, Guirong Sun, Ruili Han, Ruirui Jiang, Yadong Tian, Wenting Li, Kejun Wang, Xiangtao Kang   +14 more
wiley   +1 more source

Lysosomal Fusion: An Efficient Mechanism Increasing Their Sequestration Capacity for Weak Base Drugs without Apparent Lysosomal Biogenesis

Biomolecules, 2020
Lysosomal sequestration of anticancer therapeutics lowers their cytotoxic potential, reduces drug availability at target sites, and contributes to cancer resistance.
Nikola Skoupa, Petr Dolezel, Petr Mlejnek   +2 more
doaj   +1 more source

Unexpected Motherhood-Triggered Hearing Loss in the Two-Pore Channel (TPC) Mutant Mouse

Biomedicines, 2022
Calcium signaling is crucial for many physiological processes and can mobilize intracellular calcium stores in response to environmental sensory stimuli.
Juliette Royer, José-Manuel Cancela, Jean-Marc Edeline   +2 more
doaj   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Yuxin Ouyang, Weiwei Jiang, Xiongquan Long, Peng Mao, Pingping He, Xinping Ouyang   +5 more
wiley   +1 more source

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites

iScience, 2022
Summary: SARM1 is an NAD(P) glycohydrolase and TLR adapter with an essential, prodegenerative role in programmed axon death (Wallerian degeneration). Like other NAD(P)ases, it catalyzes multiple reactions that need to be fully investigated.
Carlo Angeletti, Adolfo Amici, Jonathan Gilley, Andrea Loreto, Antonio G. Trapanotto, Christina Antoniou, Elisa Merlini, Michael P. Coleman, Giuseppe Orsomando   +8 more
doaj   +1 more source

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, Volume 12, Issue 39, October 20, 2025.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

CD38‐Targeting Peptide Vaccine Ameliorates Aging‐Associated Phenotypes in Mice

Aging Cell, Volume 24, Issue 9, September 2025.
Shangcheng Yu et al. revealed that CD38‐targeting peptide vaccine ameliorated aging‐associated physical and cognitive phenotypes in mice. CD38‐vaccine selectively depletes CD38+ myeloid cells, improves glucose tolerance, and enhances oxygen consumption.
Shangcheng Yu, Zhiqiang Li, Yuxiang Tang, Yuling Chen, Yingying Ma, Kunlin Du, Zhaoyun Zong, Kangze Feng, Yali Wei, Limeng Chen, Haiteng Deng   +10 more
wiley   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, Volume 182, Issue 13, Page 2950-2967, July 2025.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source