Results 51 to 60 of about 1,793 (129)

To be or not to be… Nicotinic acid adenine dinucleotide phosphate (NAADP): A new intracellular second messenger?

Biological Research, 2004
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems.
EDUARDO NUNES CHINI
doaj  

Macrophages and autophagy: partners in crime

The FEBS Journal, Volume 292, Issue 12, Page 2957-2972, June 2025.
Autophagy is a key regulator of macrophage function, influencing critical processes like polarization, cytokine secretion, and phagocytosis. Its impact on macrophage behavior varies across different tissues and disease contexts, where it can either promote protective responses or contribute to detrimental outcomes, depending on the physiological or ...
Alessandra Vitaliti, Alessio Reggio, Alessandro Palma   +2 more
wiley   +1 more source

Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release. [PDF]

PLoS ONE, 2017
Arachidonic acid (AA), a compound secreted by Sertoli cells (SC) in a FSH-dependent manner, is able to induce the release of Ca2+ from internal stores in round spermatids and pachytene spermatocytes. In this study, the possible site(s) of action of AA in
Joaquin Paillamanque, Ana Sanchez-Tusie, Emerson M Carmona, Claudia L Treviño, Carolina Sandoval, Francisco Nualart, Nelson Osses, Juan G Reyes   +7 more
doaj   +1 more source

S‐acylation of Ca2+ transport proteins in cancer

Chronic Diseases and Translational Medicine, Volume 10, Issue 4, Page 263-280, December 2024.
The implication of Ca2+ transport proteins in cancer has been previously documented in several studies recently reviewed. Transporters highlighted in red have been biochemically documented to be S‐acylated. Abstract Alterations in cellular calcium (Ca2+) signals have been causally associated with the development and progression of human cancers ...
Sana Kouba, Nicolas Demaurex
wiley   +1 more source

Ned-19 inhibition of parasite growth and multiplication suggests a role for NAADP mediated signalling in the asexual development of Plasmodium falciparum

Malaria Journal, 2017
Background Although malaria is a preventable and curable human disease, millions of people risk to be infected by the Plasmodium parasites and to develop this illness. Therefore, there is an urgent need to identify new anti-malarial drugs.
Pablo Suárez-Cortés, Guido Gambara, Annarita Favia, Fioretta Palombi, Pietro Alano, Antonio Filippini   +5 more
doaj   +1 more source

CD38/cADPR‐mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1

IUBMB Life, Volume 76, Issue 12, Page 1223-1233, December 2024.
Abstract Cyclic ADP‐ribose (cADPR) has emerged as a calcium‐regulating second messenger in smooth muscle cells. CD38 protein possesses ADP‐ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium.
Soner Dogan, Timothy F. Walseth, Bilge Guvenc Tuna, Eda Uçar, Mathur S. Kannan, Deepak A. Deshpande   +5 more
wiley   +1 more source

Immunometabolism: signaling pathways, homeostasis, and therapeutic targets

MedComm, Volume 5, Issue 11, November 2024.
Metabolic enzymes can directly or indirectly impact the differentiation, activation, and proliferation of immune cells through the metabolites generated by their enzymatic activities or nonenzymatic signal interference, thereby modulating the function of immune cells.
Rongrong Xu, Xiaobo He, Jia Xu, Ganjun Yu, Yanfeng Wu   +4 more
wiley   +1 more source

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

eLife, 2020
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et al.,
Susanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, Yu Yuan, Sandra Burgstaller, Anna Scotto Rosato, Einar Krogsaeter, Nicole Urban, Katharina Jacob, Ong Nam Phuong Nguyen, Meghan T Miller, Marco Keller, Angelika M Vollmar, Thomas Gudermann, Susanna Zierler, Johann Schredelseker, Michael Schaefer, Martin Biel, Roland Malli, Christian Wahl-Schott, Franz Bracher, Sandip Patel, Christian Grimm   +22 more
doaj   +1 more source

Nanotechnology‐Fortified Manipulation of Cell Ca2+ Signaling

Small Science, Volume 4, Issue 10, October 2024.
This review explores the design rationale and constructions of nanotransducers, and highlights their interactions with Ca2+ channels, as well as the downstream effectors of Ca2+ signaling pathways. It also discusses various biomedical applications in disease treatment and neuromodulation, and limitations in current approaches, while envisioning future ...
Yaofeng Zhou, Zherui Zhang, Chen Zhou, Yuanhong Ma, Haoye Huang, Junqiu Liu, Dingcheng Zhu   +6 more
wiley   +1 more source

Astrocytic uptake of posttranslationally modified amyloid‐β leads to endolysosomal system disruption and induction of pro‐inflammatory signaling

Glia, Volume 72, Issue 8, Page 1451-1468, August 2024.
Main Points Modification of Aβ (Aβ3(pE)‐42) impairs astrocytic clearance Aβ3(pE)‐42 accumulates within the astrocytic lysosomes disrupting their function Aberrant lysosomal function links to astrocytic inflammatory response and synapse loss Abstract The disruption of astrocytic catabolic processes contributes to the impairment of amyloid‐β (Aβ ...
Sarah Wirth, Annika Schlößer, Antonia Beiersdorfer, Michaela Schweizer, Marcel S. Woo, Manuel A. Friese, Christian Lohr, Katarzyna M. Grochowska   +7 more
wiley   +1 more source