Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
Molecules, 2010 A novel trifluoromethylated analogue of cADPR, 8-CF3-cIDPDE (5) was designed and synthesized via construction of N1,N9-disubstituted hypoxanthine, trifluoromethylation and intramolecular condensation.
Min Dong, Zhenjun Yang, Kehui Zhang
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Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket [PDF]
Cell Reports, 2019 Summary: cADPR is a well-recognized signaling molecule by modulating the RyRs, but considerable debate exists regarding whether cADPR can bind to and gate the TRPM2 channel, which mediates oxidative stress signaling in diverse physiological and ...
Lin-Hua Jiang +2 more
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Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications [PDF]
Molecules, 2012 Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jianbo Yue +2 more
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Remifentanil-induced postoperative hyperalgesia is attenuated by inhibition of NMDAR-cADPR-RyRs signaling pathway in the spinal cord of rats [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the role of NMDAR-cADPR-RyRs signaling pathway in remifentanil-induced hyperalgesia(RIH). Methods The rat model of postoperative hyperalgesia induced by remifentanil was established. SD rats were randomly divided into 6 groups as:
QIAN Yue, WANG Fang, ZHANG Jing, XIA Tianjiao, GU Xiaoping
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Raw defines a TIR-fold cADPR hydrolase cooperating with dSarm in development and axon degeneration [PDF]
Cell Communication and SignalingConserved TIR domain proteins play essential roles in immune signaling, development, and neurodegeneration. SARM1/dSarm, the only known enzymatically active TIR protein in animals, has been established as a key regulator of axon degeneration through its ...
Feng Chen +15 more
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Targeting the SARM1–cADPR–Ca2+ pathway attenuates mitochondrial fragmentation and osteoarthritis progression [PDF]
Arthritis Research & TherapyIntroduction Osteoarthritis (OA) is a prevalent degenerative joint disease accompanied by increased number of senescent chondrocytes. Mitochondrial dysfunction is a well-established hallmark of chondrocyte senescence in OA pathogenesis.
Yu Gu +7 more
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A phage-encoded sponge protein suppresses bacterial TIR-Caspase immune signaling [PDF]
Nature CommunicationsTriggering immune response through generation of signal molecules is a common immune strategy across all domains of life. In the bacterial type IV Thoeris anti-phage system, a Toll/interleukin-1 receptor (TIR)-domain protein produces adenosine 5 ...
Yu Chen +13 more
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Molecular characterisation of the Bacillus subtilis SpbK antiphage defence system [PDF]
Nature CommunicationsBacteria have a variety of mechanisms for limiting predation by phages. SpbK is a Toll/interleukin-1 receptor (TIR) domain-containing antiphage defence protein from Bacillus subtilis that provides protection against the temperate phage SPβ via abortive ...
Biswa P. Mishra +15 more
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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
Frontiers in Immunology, 2020 TRPM2 is a non-selective, Ca2+-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR).
Andreas Guse, Ralf Fliegert
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Marine Drugs, 2018 Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca2+-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts.
Agnese Secondo +2 more
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