Results 21 to 30 of about 3,255 (160)

Blocking Cyclic Adenosine Diphosphate Ribose-mediated Calcium Overload Attenuates Sepsis-induced Acute Lung Injury in Rats

Chinese Medical Journal, 2016
Background: Acute lung injury (ALI) is a common complication of sepsis that is associated with high mortality. Intracellular Ca2+ overload plays an important role in the pathophysiology of sepsis-induced ALI, and cyclic adenosine diphosphate ribose ...
Qian-Yi Peng, Yu Zou, Li-Na Zhang, Mei-Lin Ai, Wei Liu, Yu-Hang Ai   +5 more
doaj   +1 more source

Coronary Angiography-Derived Diastolic Pressure Ratio

Frontiers in Bioengineering and Biotechnology, 2020
AimsBased on the aortic pressure waveform, a specially designed computational fluid dynamic (CFD) method was proposed to determine coronary angiography-derived diastolic pressure ratio (caDPR) without using invasive pressure wire. The aim of the study is
Yanjun Gong, Yundi Feng, Tieci Yi, Fan Yang, Yuxi Li, Long Zhang, Bo Zheng, Tao Hong, Zhaoping Liu, Yunlong Huo, Jianping Li, Yong Huo   +11 more
doaj   +1 more source

Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN [PDF]

, 2021
Cancer patients frequently develop chemotherapy-induced peripheral neuropathy (CIPN), a painful and long-lasting disorder with profound somatosensory deficits. There are no effective therapies to prevent or treat this disorder.
Li, Yihang, DiAntonio, Aaron, Johann S. Bergholz, Tao Jiang, Maria F. Pazyra-Murphy, Daina Avizonis, Chen, Chiung-Ya, Chiung-Ya Chen, Jean J. Zhao, Pazyra-Murphy, Maria F, Hsueh, Yi-Ping, Milbrandt, Jeffrey, Jiang, Tao, Segal, Rosalind A., Zhu, Jian, Avizonis, Daina, Sophia Tang, Rosalind A. Segal, Zhao, Jean J., Jeffrey Milbrandt, Segal, Rosalind A, Bergholz, Johann S, Aaron DiAntonio, Kwang Woo Ko, Ko, Kwang Woo, Yihang Li, Mariana de Sá Tavares Russo, Tang, Sophia, Yi-Ping Hsueh, Pazyra-Murphy, Maria F., Zhao, Jean J, Jian Zhu, de Sá Tavares Russo, Mariana, Bergholz, Johann S.   +33 more
core   +1 more source

Cyclic ADP-Ribose Requires FK506-Binding Protein to Regulate Intracellular Ca2+ Dynamics and Catecholamine Release in Acetylcholine-Stimulated Bovine Adrenal Chromaffin Cells

Journal of Pharmacological Sciences, 2006
.: The present study was undertaken to elucidate whether cyclic ADP-ribose (cADPR) mediates the amplification of Ca2+ signaling and catecholamine release via the involvement of FK506-binding proteins (FKBPs)/ryanodine receptor (RyR) in bovine adrenal ...
Morita Katsuya, Kitayama Tomoya, Kitayama Shigeo, Dohi Toshihiro   +3 more
doaj   +1 more source

On a Magical Mystery Tour with 8-Bromo-Cyclic ADP-Ribose: From All-or-None Block to Nanojunctions and the Cell-Wide Web

Molecules, 2020
A plethora of cellular functions are controlled by calcium signals, that are greatly coordinated by calcium release from intracellular stores, the principal component of which is the sarco/endooplasmic reticulum (S/ER).
A. Mark Evans
doaj   +1 more source

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway

Journal of Diabetes Investigation, 2022
Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves blood glucose levels through multiple mechanisms of action including the enhancement of glucose‐stimulated insulin secretion (GSIS), however, the details of this mechanism have ...
Shunsuke Funazaki, Masashi Yoshida, Hodaka Yamada, Masafumi Kakei, Masanobu Kawakami, Shuichi Nagashima, Kazuo Hara, Katsuya Dezaki   +7 more
doaj   +1 more source

Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion

Chinese Medical Journal, 2017
Background: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown.
Yu Zou, Xin He, Qian-Yi Peng, Qu-Lian Guo   +3 more
doaj   +1 more source

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. [PDF]

PLoS ONE, 2013
Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5'-diphosphoribose (cADPR).
Christelle Moreau, Qun Liu, Richard Graeff, Gerd K Wagner, Mark P Thomas, Joanna M Swarbrick, Satoshi Shuto, Hon Cheung Lee, Quan Hao, Barry V L Potter   +9 more
doaj   +1 more source

Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Molecules, 2021
Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing ...
Joanna M. Watt, Richard Graeff, Barry V. L. Potter   +2 more
doaj   +1 more source

TIR innovations in plant immunity. [PDF]

New Phytol
Summary Toll/interleukin‐1 receptor (TIR) domain‐containing immune receptors are crucial for plant immunity, with recent advancements highlighting the enzymatic functions of TIR domains and their production of signaling molecules. TIR‐catalyzed compounds interact with receptors to form functional modules that trigger the oligomerization of helper ...
Wu Z.
europepmc   +2 more sources