Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3 [PDF]
Cell Reports, 2021 Summary: Inositol 1,4,5-trisphosphate receptors (IP3Rs) are intracellular Ca2+ channels that link extracellular stimuli to Ca2+ signals. Ca2+ release from intracellular stores is “quantal”: low IP3 concentrations rapidly release a fraction of the stores.
Colin Taylor +2 more
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Combining IP3 affinity chromatography and bioinformatics reveals a novel protein-IP3 binding site on Plasmodium falciparum MDR1 transporter [PDF]
Current Research in Microbial Sciences, 2023 Intracellular Ca2+ mobilization induced by second messenger IP3 controls many cellular events in most of the eukaryotic groups. Despite the increasing evidence of IP3-induced Ca2+ in apicomplexan parasites like Plasmodium, responsible for malaria ...
Eduardo Alves +3 more
doaj +2 more sources
Deciphering the multi-site phos-code of IRBIT underlying its binding to IP3R [PDF]
Communications BiologyIRBIT has been previously shown to interact with the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) via a serine-rich segment. Although the interaction between IRBIT and IP3R is phosphorylation dependent, it is unclear which particular ...
Qing Lin +8 more
doaj +2 more sources
IP3 Receptor-Dependent Cytoplasmic Ca2+ Signals Are Tightly Controlled by Cavβ3
Cell Reports, 2018 Summary: Voltage-gated calcium channels (Cavs) are major Ca2+ entry pathways in excitable cells. Their β subunits facilitate membrane trafficking of the channel’s ion-conducting α1 pore and modulate its gating properties. We report that one β subunit, β3,
Andreas Beck +2 more
exaly +3 more sources
An ArfGAP-dependent signaling modulates synaptic plasticity via IP3-regulated calcium release from the endoplasmic reticulum. [PDF]
PLoS GeneticsCalcium release from intracellular stores influences synaptic response timing and magnitude. Despite the critical role of inositol trisphosphate (IP3)- and ryanodine receptor (RyR)-dependent calcium release in regulating synaptic strength, the upstream ...
Bhagaban Mallik +5 more
doaj +2 more sources
GhPIPLC2D promotes cotton fiber elongation by enhancing ethylene biosynthesis
iScience, 2021 Summary: Inositol-1,4,5-trisphosphate (IP3) is an important second messenger and one of the products of phosphoinositide-specific phospholipase C (PIPLC)-mediated phosphatidylinositol (4,5) bisphosphate (PIP2) hydrolysis.
Liping Zhu +5 more
doaj +1 more source
Dynamic regulation of IP3 receptor clustering and activity by IP3 [PDF]
Channels, 2009 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are intracellular Ca(2+) channels. Their regulation by both IP(3) and Ca(2+) allows interactions between IP(3)Rs to generate a hierarchy of intracellular Ca(2+) release events. These can progress from openings of single IP(3)R, through near-synchronous opening of a few IP(3)Rs within a cluster to much ...
Taufiq, Rahman, Colin W, Taylor
openaire +2 more sources
IRBIT Suppresses IP3 Receptor Activity by Competing with IP3 for the Common Binding Site on the IP3 Receptor [PDF]
Molecular Cell, 2006 The inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are IP3-gated intracellular Ca2+ channels. We previously identified an IP3R binding protein, IRBIT, which binds to the IP3 binding domain of IP3R and is dissociated from IP3R in the presence of IP3. In the present study, we showed that IRBIT suppresses the activation of IP3R by competing with IP3
Ando, Hideaki +5 more
openaire +3 more sources
A mathematical model of calcium dynamics in HSY cells. [PDF]
PLoS Computational Biology, 2017 Saliva is an essential part of activities such as speaking, masticating and swallowing. Enzymes in salivary fluid protect teeth and gums from infectious diseases, and also initiate the digestion process. Intracellular calcium (Ca2+) plays a critical role
Jung Min Han +3 more
doaj +1 more source
Cell Reports, 2014 Receptor-mediated oscillations in cytosolic Ca2+ concentration ([Ca2+]i) could originate either directly from an autonomous Ca2+ feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations ...
Lawrence D. Gaspers +8 more
doaj +1 more source