Results 41 to 50 of about 3,255 (160)

ISO-stimulated cADPR and NAADP production in cardiomyocytes.

, 2016
(A) Time course of cADPR and NAADP production following ISO treatment. (B and C) Differential effects of Ca2+ second messenger inhibitors on ISO-induced cADPR and NAADP formation ...
Jae-Ki Ko (2557675), Tae-Sik Nam (800090), Soo-Yeul Im (2557672), Sun-Hwa Lee (269192), Donghee Kim (165306), Asif Iqbal Shawl (780648), Kyu Yoon Jang (2557678), Rukhsana Gul (448353), Dae-Ryoung Park (780647), Uh-Hyun Kim (780651)   +9 more
core   +1 more source

Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle

, 2005
Cyclic adenosine diphosphate ribose (cADPR) is a naturally occurring cyclic nucleotide and represents a novel class of endogenous Ca2+ messengers implicated in the regulation of the gating properties of ryanodine receptors (RyRs).
Laher, I, Bai, N, Lee, HC
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

Comment on "the Arabiclopsis circadian clock incorporates a cADPR-based feedback loop"

, 2009
Dodd et al. (Reports, 14 December 2007, p. 1789) reported that the Arabidopsis circadian clock incorporates the signaling molecule cyclic adenosine diphosphate ribose (cADPR In contrast, we found that there is no rhythm of cADPR levels nor are there any ...
Gamble, KL, Mori, T, Xie, Q, Xu, X, Johnson, CH, Graeff, R   +5 more
core   +1 more source

Regulation of Renin Release via Cyclic ADP-Ribose-Mediated Signaling: Evidence from Mice Lacking CD38 Gene

Cellular Physiology and Biochemistry, 2013
Background/Aims: Despite extensive studies, the intracellular regulatory mechanism of renin production and release is still poorly understood. The present study was designed to test whether CD38-ADP-ribosylcyclase signaling pathway contributes to the ...
Jing Xiong, Min Xia, Fan Yi, Justine M. Abais, Ningjun Li, Krishna M. Boini, Pin-Lan Li   +6 more
doaj   +1 more source

Ryanodine Receptor 1 Is Dispensable for CD4+ T‐Cell Differentiation and Effector Function in Intestinal Inflammation Models

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Ryr1 deletion reduces Ca2+ microdomains and delays global Ca2+ signaling in naïve CD4+ T cells but does not impair their activation, proliferation, or differentiation in vitro. Despite altered Ca2+ signaling, Ryr1 expression in CD4+ T cells was dispensable for their pathogenicity in murine models of intestinal inflammation.
Sogol Dostiar Tabrizi, Mikolaj Nawrocki, Tanja Bedke, Marius Böttcher, Friederike Stumme, Melina Birus, Franziska Möckl, Lola Hernandez, Björn‐Phillip Diercks, Nicola Gagliani, Dmitri Lodygin, Alexander Flügel, Andreas H. Guse, Hans‐Willi Mittrücker, Samuel Huber   +14 more
wiley   +1 more source

Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.

PLoS ONE, 2012
The ADPRibase-Mn-like protein family, that belongs to the metallo-dependent phosphatase superfamily, has different functional and structural prototypes.
Joaquim Rui Rodrigues, Ascensión Fernández, José Canales, Alicia Cabezas, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle   +6 more
doaj   +1 more source

Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Scientific Reports, 2020
Oxytocin (OT) is a critical molecule for social recognition and memory that mediates social and emotional behaviours. In addition, OT acts as an anxiolytic factor and is released during stress. Based on the activity of CD38 as an enzyme that produces the
Maria Gerasimenko, Stanislav M. Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B. Salmina, Anna A. Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida   +10 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source