Results 51 to 60 of about 3,255 (160)

Conversion of NAD⁺ into cADPR and ADPR.

, 2013
Conversion of NAD+ into cADPR and ADPR.
Gerd K. Wagner (423554), Hon Cheung Lee (423557), Christelle Moreau (423552), Qun Liu (67203), Mark P. Thomas (423555), Satoshi Shuto (102368), Joanna M. Swarbrick (423556), Barry V. L. Potter (286876), Quan Hao (67204), Richard Graeff (423553)   +9 more
core   +1 more source

Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.

PLoS ONE, 2021
Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes.
Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sébastien Bolze, David E Moller   +4 more
doaj   +1 more source

Remission of social behavior impairment by oral administration of a precursor of NAD in CD157, but not in CD38, knockout mice

Frontiers in Immunology, 2023
Nicotinamide adenine dinucleotide (NAD) is a substrate of adenosine diphosphate (ADP)-ribosyl cyclase and is catalyzed to cyclic ADP-ribose (cADPR) by CD38 and/or CD157.
Maria Gerasimenko, Haruhiro Higashida
doaj   +1 more source

Recent Advances in the Molecular Mechanisms of Bacterial Anti‐Phage Defence Systems

Microbial Biotechnology, Volume 19, Issue 8, August 2026.
Panoptes as an example for an antiphage system consists of OptS producing a cyclic dinucleotide that prevents activation of OptE, a transmembrane protein. Phage T4 infection introduces the sponge protein Acb2 that adsorbs the cyclic dinucleotide thus activating OptE which disrupts the cell membrane aborting phage infection.
Harald Brüssow
wiley   +1 more source

Roles of cADPR and NAADP in pancreatic cells

, 2012
Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are Ca(2+)-mobilizing nucleotides that were discovered in the late 1980s.
Richard Graeff, Hon Cheung Lee, Yongjuan Zhao, Zhao, Y, Graeff, R, Lee, HC   +5 more
core   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

Cell Reports, 2020
Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung   +11 more
doaj   +1 more source

The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression

Cell Death and Disease, 2021
It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody therapy, which led to dysfunction of tumor-infiltrating CD8+ T immune cells due to increasing the ...
Long Gao, Yuan Liu, Xiaohong Du, Sai Ma, Minmin Ge, Haijun Tang, Chenfeng Han, Xin Zhao, Yanbin Liu, Yun Shao, Zhao Wu, Lianjun Zhang, Fang Meng, F. Xiao-Feng Qin   +13 more
doaj   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells.

, 2002
cADPR, a potent calcium-mobilizing intracellular messenger synthesized by ADP-ribosyl cyclases regulates openings of ryanodine receptors (RyR). Here we report that in the rat testis, a functional cADPR Ca2+ release system is essential for the contractile
Churchill, G. C., SORRENTINO V, GENAZZANI F, Sorrentino, V., Ziparo, E, PALOMBI F, Palombi, F., ZIPARO, Elio, Conti, A, Filippini, A, Conti, A., Genazzani, AA, Barone, F., GALIONE A, Ziparo, E., Sorrentino, V, Genazzani, A. A., Churchill, Grant, FILIPPINI, Antonio, Churchill, GC, BARONE F, CHURCHILL G. C, Galione, A., Filippini, A., CONTI A, Palombi, F, Barone, F, Galione, A, Galione, Antony   +28 more
core   +1 more source