Results 71 to 80 of about 3,255 (160)

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

eLife, 2019
TRPM2 is critically involved in diverse physiological processes including core temperature sensing, apoptosis, and immune response. TRPM2’s activation by Ca2+ and ADP ribose (ADPR), an NAD+-metabolite produced under oxidative stress and neurodegenerative
Yihe Huang, Becca Roth, Wei Lü, Juan Du
doaj   +1 more source

Adenine dinucleotide second messengers and T-lymphocyte calcium signaling

Frontiers in Immunology, 2013
Calcium signaling is a universal signal transduction mechanism in animal and plant cells. In mammalian T-lymphocytes calcium signaling is essential for activation and re-activation and thus important for a functional immune response.
Insa MA Ernst, Ralf eFliegert, Andreas H Guse   +2 more
doaj   +1 more source

2′-Deoxy Cyclic Adenosine 5′-Diphosphate Ribose Derivatives: Importance of the 2′-Hydroxyl Motif for the Antagonistic Activity of 8-Substituted cADPR Derivatives

, 2015
The structural features needed for antagonism at the cyclic ADP-ribose (cADPR) receptor are unclear. Chemoenzymatic syntheses of novel 8-substituted 2′-deoxy-cADPR analogues, including 8-bromo-2′-deoxy-cADPR 7, 8-amino-2′-deoxy-cADPR 8, 8-O-methyl-2 ...
Gerd K. Wagner (423554), Clive Garnham (1264299), Anthony J. Morgan (1264305), Bo Zhang (6559), Barry V. L. Potter (286876), Karin Weber (31717), Antony Galione (1264302), Andreas H. Guse (78011)   +7 more
core   +1 more source

Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose

Brazilian Journal of Medical and Biological Research, 2006
Store-operated Ca2+ entry plays an important role in Ca2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel
Thompson M., White T., Chini E.N.
doaj  

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

Molecules, 2011
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli, Vincenzo Piccialli, Luciano Mayol, Michela Varra, Jussara Amato, Nicola Borbone, Giorgia Oliviero, Stefano D’Errico   +7 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Molecular characterization of novel ADP-ribosyl cyclases from the sea urchin [PDF]

, 2010
Calcium signalling is ubiquitous and regulates diverse cellular processes. Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are second messengers that are involved in calcium release from the intracellular organelles ...
Ramakrishnan, L.
core  

β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.

, 2012
Evidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleotide phosphate) and cADPR (cyclic ADP-ribose ...
Shipman, K, Masgrau, R, Thomas, JM, Paramore, C, Aley, PK, Lewis, AM, Churchill, Grant, Terrar, Derek, Roomi, A, Garnham, C, Sanders, LE, Churchill, GC, Terrar, DA, Bloor-Young, D, Sanders, LEL, Galione, A, Galione, Antony   +16 more
core   +1 more source

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers [PDF]

, 2018
Cyclic adenosine 5′-diphosphate ribose (cADPR) is an emerging Ca2+-mobilising second messenger. cADPR analogues have been generated as chemical biology tools via both chemo-enzymatic and total synthetic routes.
Watt, J, Joanna M. Watt, Mark P. Thomas, Thomas, MP, Barry V. L. Potter, Potter, Barry, Potter, BVL, Watt, Joanna   +7 more
core   +1 more source