Results 81 to 90 of about 3,255 (160)

DHPG-induced intracellular Ca²⁺ mobilization occurs via the cADPR/RyR signaling pathways.

, 2013
DHPG-induced Ca2+ transients were completely inhibited when cells were pretreated with 5 mM nicotinamide (A), 100 µM 8-NH2-cADPR (B), or 20 µM ryanodine (C) prior to the second application of DHPG.
Jong-Woo Sohn (341431), Weon-Jin Yu (341432), Suk-Ho Lee (341434), Hee-Sup Shin (5652715), Won-Kyung Ho (341435), Doyun Lee (341433)   +5 more
core   +1 more source

Cyclic ADP-Ribose Modulates Intracellular Calcium Homeostasis and Anagen-Associated Signaling Pathways in Human Hair Follicle Dermal Papilla Cells

Applied Sciences
Background: Hair loss (alopecia) is primarily driven by the premature transition of hair follicles from the anagen (growth) to the catagen (regression) phase.
Jihwan Shin, Migyoung Yang, Geunsik Jung
doaj   +1 more source

2'-deoxy cyclic adenosine 5'-diphosphate ribose derivatives: importance of the 2'-hydroxyl motif for the antagonistic activity of 8-substituted cADPR derivatives.

, 2008
The structural features needed for antagonism at the cyclic ADP-ribose (cADPR) receptor are unclear. Chemoenzymatic syntheses of novel 8-substituted 2'-deoxy-cADPR analogues, including 8-bromo-2'-deoxy-cADPR 7, 8-amino-2'-deoxy-cADPR 8, 8- O-methyl-2 ...
Garnham, C, Morgan, AJ, Guse, AH, Zhang, B, Wagner, GK, Morgan, Anthony, Potter, BV, Potter, BVL, Weber, K, Galione, A, Galione, Antony   +10 more
core   +1 more source

L-thyroxine modifies nephrotoxicity by regulating the apoptotic pathway: The possible role of CD38/ADP-ribosyl cyclase-mediated calcium mobilization.

PLoS ONE, 2017
Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly, Dina M El-Sharawy, Marwa S El Refaye, Sahar S Abd El-Rahman   +3 more
doaj   +1 more source

Probing the Ca2+ mobilizing properties on primary cortical neurons of a new stable cADPR mimic

, 2021
Cyclic adenosine diphosphate ribose (cADPR) is a second messenger involved in the Ca2+ homeostasis. Its chemical instability prompted researchers to tune point by point its structure, obtaining stable analogues featuring interesting biological properties.
Marzano M., Secondo A., Terracciano M., D'Errico S., Oliviero G., Tedeschi V., Piccialli I., Greco F., Roviello G. N., Borbone N., Patrizia Falanga A.   +10 more
core   +1 more source

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca²⁺-Modulating Activity Isolated from Sea Urchin Eggs

Marine Drugs, 2019
Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca2+ mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts ...
Stefano D’Errico, Emy Basso, Andrea Patrizia Falanga, Maria Marzano, Tullio Pozzan, Vincenzo Piccialli, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone   +8 more
doaj   +1 more source

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of Inflammation, 2018
Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande, Alonso G. P. Guedes, Richard Graeff, Soner Dogan, Subbaya Subramanian, Timothy F. Walseth, Mathur S. Kannan   +6 more
doaj   +1 more source

Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision

Molecular Brain, 2018
Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. The ability of single neurons to transform their input into output action potential is primarily determined by intrinsic ...
Weonjin Yu, Jong-Woo Sohn, Jaehan Kwon, Suk-Ho Lee, Sooyun Kim, Won-Kyung Ho   +5 more
doaj   +1 more source

A proposed enzymatic pathway for generating pRib-AMP from cADPR in P. falciparum.

, 2013
A proposed enzymatic pathway for generating pRib-AMP from cADPR in P. falciparum.
Shane E. Tichy (401176), William L. Gosnell (401179), Norton Kitagawa (401177), D. Benjamin Gordon (401175), Theodore R. Sana (13537), Cindy Lai (401178), Steven M. Fischer (157619), Sandra P. Chang (401180)   +7 more
core   +1 more source

Potentiation of cADPR-Induced Ca2+-Release by Methylxanthine Analogues

, 1999
Caffeine and other methylxanthines are known to induce Ca2+-release from intracellular stores via the ryanodine receptor. In the present work, a range of caffeine analogues, in which methyl groups at the 1 and 7 positions were replaced with alkyl chains ...
GALUPPI A., GENAZZANI A. A., FILOCAMO, Luigi, GALIONE A., CAVALLARO R. A., BRUFANI, Mario   +5 more
core   +1 more source