Results 61 to 70 of about 3,255 (160)

Characterization of extracellular and membrane potentials in imeglimin‐treated islets

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 561-566, April 2026.
ABSTRACT Glucose‐stimulated insulin secretion (GSIS) in β cells depends critically on membrane depolarization–induced Ca2+ influx. Accordingly, the electrophysiological assessment of intact islets, where β cells act as functional syncytia, is essential for evaluating insulin secretory dynamics. Imeglimin, an oral agent used in treating type 2 diabetes,
Asuka Tsurumoto, Ryota Inoue, Esther Ong Yajima, Meng Zou, Junyu Luo, Takahiro Tsuno, Emi Ishida, Kohichi Matsunaga, Jun Shirakawa   +8 more
wiley   +1 more source

Calcium release in permeabilized DU-145 cells in response to cADPR with and without 50 µM BA present.

, 2013
A.
Sarah Kobylewski (372103), Kimberly Henderson (372101), Curtis D. Eckhert (372104), Salvatore L. Stella Jr (136690)   +3 more
core   +1 more source

Carvedilol inhibits cADPR- and IP3-induced Ca2+ release

, 2017
Spontaneous Ca2+ waves, also termed store-overload-induced Ca2+ release (SOICR), in cardiac cells can trigger ventricular arrhythmias especially in failing hearts.
Morgan, AJ, Bampali, K, Factor, C, Morgan, Anthony J., Ruas, M, Back, TG, Galione, A, Chen, SRW, Galione, Antony   +8 more
core   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells [PDF]

, 2006
peer reviewedIn human phagocytic cells, reactive oxygen species (ROS) generation in response to N-formyl-L-Methionyl-L-Leucyl-L-Phenylalanine (fMLF) is largely dependent on cytosolic free calcium concentration ([Ca2+]i). Cyclic ADP-ribose (cADPr) is able
BUEB, Jean-Luc, Bréchard, S., Brunello, A., BRÉCHARD, Sabrina, Bueb, J.-L., TSCHIRHART, Eric, Tschirhart, E.J.   +6 more
core   +1 more source

Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel

BMC Neurology
Background Approximately 70% of patients receiving neurotoxic chemotherapy (e.g., paclitaxel or vincristine) will develop chemotherapy-induced peripheral neuropathy.
Robert Knoerl, Emanuele Mazzola, Maria Pazyra-Murphy, Birgitta Ryback, A. Lindsay Frazier, Roy L. Freeman, Marilyn Hammer, Ann LaCasce, Jennifer Ligibel, Marlise R. Luskin, Donna L. Berry, Rosalind A. Segal   +11 more
doaj   +1 more source

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
JEV infection in brain tissue triggers inflammation and stress in neuronal cells, leading to NAD+ depletion via the overactivation of PARPs and SIRTs. While compensatory biosynthetic pathways (de novo and salvage) were upregulated, the NAD+ level fell critically. In vitro NAMPT inhibition exacerbates this deficit and viral load.
Takele Adugna Kassegn, Zhancheng Tian, Junzheng Du, Qingli Niu, Jifei Yang, Zhang Hongge, Yuqing Song, Fengxue Chai, Zhonghui Zhang, Guiquan Guan, Hong Yin   +10 more
wiley   +1 more source

Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway

, 2012
Cyclic adenosine diphosphoribose (cADPR) is an endogenous Ca(2+) mobilizing messenger that is formed by ADP-ribosyl cyclases from nicotinamide adenine dinucleotide (NAD).
Zhang, LH, Lee, Hon-Cheung, Li, Gui-Rong, Lee, HC, Li, GR, Wei, WJ, Yue, J, Ting, Kai Yiu, Zhang, Li-He, Ting, KY, Wei, Wen-Jie, Sun, Hai-Ying, Sun, HY, Yue, Jianbo   +13 more
core   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Copper-induced activation of TRPs and VDCCs triggers a calcium signature response regulating gene expression in Ectocarpus siliculosus [PDF]

PeerJ, 2018
In certain multicellular photoautotrophs, such as plants and green macroalgae, it has been demonstrated that calcium signaling importantly mediates tolerance to copper excess.
Alberto González, Claudio A. Sáez, Alejandra Moenne   +2 more
doaj   +2 more sources