Results 1 to 10 of about 2,545,682 (269)

Live Synthesis

Innovations in Systems and Software Engineering, 2021
AbstractSynthesis automatically constructs an implementation that satisfies a given logical specification. In this paper, we study the live synthesis problem, where the synthesized implementation replaces an already running system. In addition to satisfying its own specification, the synthesized implementation must guarantee a sound transition from the
Finkbeiner, Bernd, Klein, Felix, Metzger, Niklas   +2 more
openaire   +3 more sources

Total wash elimination for solid phase peptide synthesis

Nature Communications, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins, Sandeep K. Singh, Travis A. White, Drew J. Cesta, Colin L. Simpson, Levi J. Tubb, Christopher L. Houser   +6 more
doaj   +1 more source

Knockout of Tmlhe in mice is not associated with autism spectrum disorder phenotypes or motor dysfunction despite low carnitine levels

Molecular Autism, 2023
Deletion of exon 2 of the trimethyllysine hydroxylase epsilon (TMLHE) gene was identified in probands with autism spectrum disorder (ASD). TMLHE encodes the first enzyme in carnitine biosynthesis, N6-trimethyllysine dioxygenase (TMLD).
Edgars Liepinsh, Baiba Svalbe, Gundega Stelfa, Solveiga Grinberga, Liga Zvejniece, Helgi B. Schiöth, Maija Dambrova   +6 more
doaj   +1 more source

Network meta-analysis of eribulin versus other chemotherapies used as second- or later-line treatment in locally advanced or metastatic breast cancer

BMC Cancer, 2021
Background Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and in the European Union in locally ...
Qi Zhao, Rachel Hughes, Binod Neupane, Kristin Mickle, Yun Su, Isabelle Chabot, Marissa Betts, Ananth Kadambi   +7 more
doaj   +1 more source

Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole. [PDF]

ChemInform, 2005
An enantioselective total synthesis of the naturally occurring antitubercular agent pseudopteroxazole is described. The synthesis is organized around the use of a stereoselective, intramolecular addition of a sulfoximine carbanion to an alpha,beta-unsaturated ester to form an enantiomerically pure benzothiazine.
Michael, Harmata, Xuechuan, Hong
openaire   +2 more sources

Total Synthesis of Apoptolidin:  Completion of the Synthesis and Analogue Synthesis and Evaluation [PDF]

Journal of the American Chemical Society, 2003
The total synthesis of apoptolidin (1) is reported together with the design, synthesis, and biological evaluation of a number of analogues. The assembly of key fragments 6 and 7 to vinyl iodide 3 via dithiane coupling technology was supplemented by a second generation route to this advanced intermediate involving a Horner-Wadsworth-Emmons coupling of ...
K C, Nicolaou, Yiwei, Li, Kazuyuki, Sugita, Holger, Monenschein, Prasuna, Guntupalli, Helen J, Mitchell, Konstantina C, Fylaktakidou, Dionisios, Vourloumis, Paraskevi, Giannakakou, Aurora, O'Brate   +9 more
openaire   +2 more sources

A Path to Improved Alzheimer’s Care: Simulating Long-Term Health Outcomes of Lecanemab in Early Alzheimer’s Disease from the CLARITY AD Trial

Neurology and Therapy, 2023
Introduction Alzheimer’s disease (AD), a progressive neurodegenerative disease, is the main cause of dementia and one of the leading causes of death for elderly people in the USA.
Amir Abbas Tahami Monfared, Weicheng Ye, Aditya Sardesai, Henri Folse, Ameya Chavan, Elena Aruffo, Quanwu Zhang   +6 more
doaj   +1 more source

Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production

Scientific Reports, 2020
The development of targeted drugs for the treatment of cancer remains an unmet medical need. This study was designed to investigate the mechanism underlying breast cancer cell growth suppression caused by fused isoselenazolium salts.
Marina Makrecka-Kuka, Pavels Dimitrijevs, Ilona Domracheva, Kristaps Jaudzems, Maija Dambrova, Pavel Arsenyan   +5 more
doaj   +1 more source

Structured expert elicitation to inform long-term survival extrapolations using alternative parametric distributions: a case study of CAR T therapy for relapsed/ refractory multiple myeloma

BMC Medical Research Methodology, 2022
Background Our aim was to extend traditional parametric models used to extrapolate survival in cost-effectiveness analyses (CEAs) by integrating individual-level patient data (IPD) from a clinical trial with estimates from experts regarding long-term ...
Dieter Ayers, Shannon Cope, Kevin Towle, Ali Mojebi, Thomas Marshall, Devender Dhanda   +5 more
doaj   +1 more source

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

Physiological Reports, 2020
Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury.
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh   +7 more
doaj   +1 more source