Results 21 to 30 of about 5,131,645 (316)

Estimated Societal Value of Lecanemab in Patients with Early Alzheimer’s Disease Using Simulation Modeling

Neurology and Therapy, 2023
Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with memory, cognitive, and behavioral deficits, and brings significant economic burden on caregivers and healthcare systems.
Amir Abbas Tahami Monfared, Weicheng Ye, Aditya Sardesai, Henri Folse, Ameya Chavan, Kang Kang, Quanwu Zhang   +6 more
doaj   +1 more source

Synthesis of Allahabadolactone A [PDF]

The Journal of Organic Chemistry, 2017
A synthesis of allahabadolactone A is described employing diastereoselective Diels-Alder and selenocyclization reactions, starting from (R)-citronellal and propylene oxide. The Diels-Alder substrate is built up in an efficient manner by rhodium-catalyzed alkyne hydroboration and palladium-catalyzed coupling reactions of E-1,2-dichloroethene.
Kongchen Wang, Roderick W. Bates
openaire   +4 more sources

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

Physiological Reports, 2020
Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of immune cells ...
Edgars Liepinsh, Elina Makarova, Liga Plakane, Ilze Konrade, Kaspars Liepins, Melita Videja, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka‐Kuka, Maija Dambrova   +9 more
doaj   +1 more source

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure

Frontiers in Cell and Developmental Biology, 2021
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in host organisms from specific food constituents, such as choline, carnitine and betaine. During the last decade, elevated TMAO levels have been proposed as biomarkers
Melita Videja, Melita Videja, Reinis Vilskersts, Reinis Vilskersts, Stanislava Korzh, Helena Cirule, Eduards Sevostjanovs, Maija Dambrova, Maija Dambrova, Marina Makrecka-Kuka   +9 more
doaj   +1 more source

Synthesis of (‐)‐Sordarin

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kitamura, Mitsuru, Chiba, Shunsuke, Narasaka, Koichi   +2 more
openaire   +3 more sources

Detection of Anti-viral Drug Riamilovir and Herbicides in Aqueous Media by Using Pyrene-based Fluorescent Chemosensors

Chimica Techno Acta, 2021
Two ethyleneglycol esters of 1-pyrene carboxylic acid were studied as chemosensors for the fluorescence “turn-off” detection of two nitro-containing analytes, such as antiviral drug Riamilovir (Triazavirin ®) and herbicidal agent dinitro-ortho-cresol ...
I. S. Kovalev, L. K. Sadieva, O. S. Taniya, D. S. Kopchuk, G. V. Zyryanov, E. N. Ulomsky, V. L. Rusinov, O. N. Chupakhin   +7 more
doaj   +1 more source

A scalable, chromatography-free synthesis of benzotetramisole [PDF]

, 2015
The authors thank the Royal Society for a University Research Fellowship (ADS), the EPSRC (EP/J018139/1, DSBD), and GSK (Case award to SRS) for funding. They also thank the European Research Council under the European Union’s Seventh Framework Programme (
Smith, Siobhan Rose, Smith, Andrew David, Shapland, P., Lebl, Tomas, Daniels, David Sydney Bernard   +4 more
core   +1 more source

Bispyrenylalkane Chemosensor for the Naked-eye Detection of Nitro-explosives

Chimica Techno Acta, 2021
Pyrene-based compounds have a great potential as fluorescent chemosensors for various analytes including common nitro-explosives, such as 2,4,6-trinitrotoluene (TNT).
I. S. Kovalev, L. K. Sadieva, O. S. Taniya, V. M. Yurk, A. S. Minin, D. S. Kopchuk, G. V. Zyryanov, V. N. Charushin, O. N. Chupakhin   +8 more
doaj   +1 more source

Synthesis of (–)-Muricatacin [PDF]

Bioscience, Biotechnology, and Biochemistry, 1993
The synthesis of (-)-muricatacin starting from 1-bromododecane and 2-pentyn-1-ol is described. 2-Pentadecyn-1-ol (4), which was prepared from 1-bromododecane (2) and 2-pentyn-1-ol (3), was converted to epoxy alcohol 6 through a two-step reaction sequence, 6 being successively submitted to tosylation, iodination, chain extension with tert-butyl ...
Makabe, Hidefumi, Tanaka, Akira, Oritani, Takayuki   +2 more
openaire   +2 more sources

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

Molecules, 2023
SARS-CoV-2 nsp14 guanine-N7-methyltransferase plays an important role in the viral RNA translation process by catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to viral mRNA cap.
Olga Bobileva, Raitis Bobrovs, Evelina Elva Sirma, Iveta Kanepe, Anna L. Bula, Liene Patetko, Anna Ramata-Stunda, Solveiga Grinberga, Aigars Jirgensons, Kristaps Jaudzems   +9 more
doaj   +1 more source