Acyl-1,4-Dihydropyridines: Universal Acylation Reagents for Organic Synthesis [PDF]
MoleculesAcyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals.
Karthikeyan Manoharan, Bartosz Bieszczad
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Antileishmanial and Antitoxoplasmal Activities of 1,4-Dihydropyridines [PDF]
ACS OmegaAbstract: We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major.
Thaís A. S. Oliveira +9 more
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Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines [PDF]
Data in Brief, 2020 This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins +6 more
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Ammonium metavanadate (NH4VO3): a highly efficient and eco-friendly catalyst for one-pot synthesis of pyridines and 1,4-dihydropyridines [PDF]
Scientific Reports, 2022 In this study, we reported the ammonium metavanadate (NH4VO3) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction.
Jamal Rahimi +6 more
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Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines [PDF]
MoleculesThe oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry.
Wanwan Wang, Lei Yu
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Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine [PDF]
Molecules, 2019 The number of effective antituberculotic drugs is strongly limited to four first-line drugs in standard therapy. In case of resistances second-line antibiotics are used with a poor efficacy and tolerability.
Fabian Lentz +6 more
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Eco-friendly and efficient synthesis of 1,4-dihydropyridines using a recyclable l-arginine-modified magnetic natural phosphate nanocatalyst [PDF]
Scientific ReportsA magnetic natural phosphate functionalized with arginine (MNP‑Arg) was synthesized and fully characterized using FTIR, XRD, XRF, SEM/EDS, VSM, and elemental analysis, which confirmed the successful functionalization and magnetic behavior of the ...
Manuchehr Rahimi +2 more
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Antischistosomal Activity of 1,4-Dihydropyridines
Drugs and Drug CandidatesBackground/Objectives: Recent reports have demonstrated the antiparasitic activity of 1,4-dihydropyridine (1,4-DHPs). This study aimed to assess the in vitro antischistosomal activity of 24 1,4-DHPs against Schistosoma mansoni adult worms.
Thaís A. S. Oliveira +5 more
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Chemistry Proceedings, 2023 Hantzsch 1,4-dihydropyridines (Hantzsch 1,4-DHP), have been utilized as starting material in organic synthesis. In addition, several 1,4-DHP based drugs (Nifedipine, Niguldipine, Amlodepine besylate) have been recognized for the treatment of ...
Juan Enrique Tacoronte Morales +4 more
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Efficient One-Pot Synthesis of 1,4-Dihydropyridines Catalyzed by Magnetic MnFe2O4 Nanoparticles
Acta Chimica Slovenica, 2022 The efficient one-pot synthesis of some 1,4-dihydropyridines is described by a condensation reaction of some aldehyde derivatives, ethyl acetoacetate and ammonium acetate in the presence of superparamagnetic manganese ferrite nanoparticles at 80 °C.
Somayeh Moradi +2 more
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