Results 1 to 10 of about 1,683 (133)

Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines [PDF]

ACS Omega
Abstract: We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reac-tion and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major.
Thaís Oliveira, Yan Robles, Ibrahim Al Nasr, Waleed Koko, Tariq Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha Ben Said, Antônio Crotti   +9 more
openaire   +4 more sources

Organocatalytic Enantioselective Synthesis of 1,4‐Dihydropyridines [PDF]

Advanced Synthesis & Catalysis, 2017
AbstractThis review aims to bring light upon a very interesting group of compounds, the 1,4‐dihydropyridines (1,4‐DHPs). These structures are well‐known pharmacophores, used for many years to treat cardiovascular diseases because of their activity as calcium channel blockers.
Auria-Luna, Fernando, Marqués-López, Eugenia, Herrera, Raquel P.   +2 more
openaire   +2 more sources

Smart cellulose‐based room temperature phosphorescent materials: From mechanisms to construction strategies and applications

Smart Molecules, EarlyView.
This review elucidates the photophysical mechanisms of cellulose‐based room temperature phosphorescent materials and systematically outlines their construction strategies, such as cluster emission center engineering. This article demonstrates their applications in fields like information encryption and bioimaging, and looks ahead to the core challenges
Shasha Wu, Yifan Zhou, Wanjin Wu, Yan Tang, Mengfan Jing, Jianyu Zhang, Haoke Zhang, Zheng Zhao, Junwei Wang, Laurent Maron, Lijie Liu   +10 more
wiley   +1 more source

Dimethyl‐, Diethyl‐, and Propylene Carbonates: An Emerging Class of Green Solvents for Organic Synthesis

The Chemical Record, EarlyView.
This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros, Livia C. L. Valente, Thiago Barcellos, Daniela Hartwig, Laura Abenante, Eder J. Lenardão   +5 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Conformation of 1,4‐dihydropyridine — planar or boat‐like? [PDF]

FEBS Letters, 1988
The geometry of the 1,4‐dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G). The most reliable 6–31G* basis set provides a very flat boat conformation which may easily undergo defolding to a planar ring arrangement.
H. Hofmann, CIMIRAGLIA, Renzo
openaire   +2 more sources

A Combined MS/MS and IMS Study Into the Fragmentation Pathway of Nifedipine

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Collision‐induced dissociation (CID) of small molecules, typically with a molecular mass below 1500 Da, is widely applied for the structural identification of drug metabolites, synthetic by‐products and unknown compounds. Nonetheless, the interpretation of MS/MS spectra derived from protonated or sodiated molecules mainly relies on the ...
Peiliang Han, Newton Thomassen, Maarten Honing   +2 more
wiley   +1 more source

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio, René Slot Bitsch, Karl Anker Jørgensen   +2 more
wiley   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source