Results 1 to 10 of about 4,506 (161)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates

Molecules, 2015
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions.
Brigita Vigante, Martins Rucins, Aiva Plotniece, Karlis Pajuste, Iveta Luntena, Brigita Cekavicus, Egils Bisenieks, Rufus Smits, Gunars Duburs, Arkadij Sobolev   +9 more
doaj   +1 more source

The issue of the cardiovascular safety of dihydropyridines [PDF]

American Journal of Hypertension, 1996
This review describes aspects of the calcium channel blocker controversy as it relates to hypertensive and coronary artery disease patients. Much of the controversy has occurred because of off-label use of short-acting calcium channel blockers that were never approved or recommended for use in patients with hypertension or acute myocardial infarction ...
openaire   +2 more sources

Results of a meta-analysis comparing the tolerability of lercanidipine and other dihydropyridine calcium channel blockers

Кардиоваскулярная терапия и профилактика, 2010
Background. Results from clinical studies suggest that the dihydropyridine calcium channel blocker (d-CCB) lercanidipine may be associated with a lower incidence of peripheral edema than are older d-CCBs. Aim. To conduct a meta-analysis of published data
K. Makarounas-Kirchmann, S. Glover-Koudounas, P. Ferrari   +2 more
doaj  

A multifaceted approach for the development of novel Hantzsch 1,4-dihydropyridines as anticancer agents: Rational design, parallel synthesis, analysis, cytotoxicity and EGFR/HER2 inhibition studies

Results in Chemistry
Dihydropyridines (DHPs) exhibit a wide range of pharmacological properties especially against cancer. In this context, a new series of 1,4-dihydropyridines were meticulously designed employing scaffold hybridization technique targeting the EGFR/HER2 ...
A.S.V.L. Sruthi, Syed Faizan, Hemant Vikram, N.G. Veena, Aishwarya Susil, Haritha Harindranath, S. Vasanth Kumar, Vasanth Kumar Shivaraju, B.R. Prashantha Kumar   +8 more
doaj   +1 more source

The role of amlodipine (norvasc) in Cardiology

КардиоСоматика, 2014
The review concerns amlodipine - the representative of the third generation of dihydropyridines. Amlodipine, being considered a hypotensive drug, has a broad spectrum of clinical effects beyond the hypotensive effects.
D. M Aronov
doaj  

Organophotoredox/Cobalt‐Catalyzed Retro‐Hydroformylation of Aldehydes

ChemistryEurope
A new cobalt/organophotoredox dual catalytic system is reported for the efficient retro‐hydroformylation of aldehydes. Under the optimized conditions, a wide range of α‐monosubstituted aldehydes are readily transformed into the desired alkenes in a one ...
Augustin Nouaille, Emmanuel Magnier, Corinne Gosmini, Guillaume Dagousset   +3 more
doaj   +1 more source

Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.
Mohammad Mahmoodi Hashemi, Mohammad Sadegh Zakeri, Saeed Arianfar   +2 more
doaj  

Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2002
The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi, Yousef Ahmadibeni   +1 more
doaj  

Synthesis of 2-Mono and 2,6-Disubstituted Methyl-1,4-Dihydropyridines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1997
The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.
Yousef Rastgar Mirzaei, Karim Akbari Dilmaghani   +1 more
doaj  

AROMATIZATION OF 1,4-DIHYDROPYRIDINES WITH FREE RADICAL REAGENTS [PDF]

Journal of Sciences, Islamic Republic of Iran, 2001
Oxidation of different types of 1,4-dihydropyridines with diphenylpicrylhydrazyl (DPP) and benzoyl peroxide (Bz2O2) as free radical oxidizing agents to pyridine derivatives is reported and a mechanism for this oxidation is also proposed.
doaj