Results 1 to 10 of about 4,532 (195)

Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis. [PDF]

PLoS Genetics
Small-molecule screens can advance therapeutic discovery and uncover new features of pathogen biology. Through a luminescence-based screen, we identified clinically approved dihydropyridines that impaired fitness of the intracellular pathogen Brucella ...
Thomas Kim, Bongjin Hong, Rosemary Northcote, Thomas V O'Halloran, Erika Lisabeth, Richard R Neubig, Aretha Fiebig, Sean Crosson   +7 more
doaj   +2 more sources

Catalytic Enantioselective Diboration of 1,2-Dihydropyridines. [PDF]

Angew Chem Int Ed Engl
Abstract Dihydropyridines undergo enantioselective 1,4‐diboration in the presence of a chiral Pt‐based catalyst. The resulting diboryl piperidines can undergo diverse stereospecific cross‐couplings, allowing the construction of an array of different substituted chiral piperidines.
Liang H, Morken JP.
europepmc   +4 more sources

A Reappraisal of the Effects of L-type Ca2+ Channel Blockers on Store-Operated Ca2+ Entry and Heart Failure

Function, 2023
Dihydropyridines such as amlodipine are widely used as antihypertensive agents, being prescribed to ∼70 million Americans and >0.4 billion adults worldwide. Dihydropyridines block voltage-gated Ca2+ channels in resistance vessels, leading to vasodilation
Gary S Bird, Diane D’Agostin, Safaa Alsanosi, Stefanie Lip, Sandosh Padmanabhan, Anant B Parekh   +5 more
doaj   +1 more source

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor^®

Molecules, 2020
New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride ...
Nadiia V. Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins, Brigita Vigante, Marina Petrova, Ruslan Muhamadejev, Karlis Pajuste, Yuriy G. Shermolovich   +8 more
doaj   +1 more source

Dihydropyridines Potentiate ATP-Induced Currents Mediated by the Full-Length Human P2X5 Receptor

Molecules, 2022
The P2X5 receptor, an ATP-gated cation channel, is believed to be involved in tumor development, inflammatory bone loss and inflammasome activation after bacterial infection. Therefore, it is a worthwhile pharmacological target to treat the corresponding
Ida C. Schiller, Kenneth A. Jacobson, Zhiwei Wen, Aparna Malisetty, Günther Schmalzing, Fritz Markwardt   +5 more
doaj   +1 more source

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines

Data in Brief, 2020
This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins, Klavs Pajuste, Arkadij Sobolev, Mara Plotniece, Nadiia Pikun, Karlis Pajuste, Aiva Plotniece   +6 more
doaj   +1 more source

Repurposing drugs with specific activity against L-form bacteria

Frontiers in Microbiology, 2023
Cell wall deficient “L- form” bacteria are of growing medical interest as a possible source of recurrent or persistent infection, largely because of their complete resistance to cell wall active antibiotics such as β-lactams.
Kaveh Emami, Kaveh Emami, Peter Banks, Ling Juan Wu, Ling Juan Wu, Jeffery Errington, Jeffery Errington   +6 more
doaj   +1 more source

SYNTHESIS AND PRELIMINARY ALKYLATING ACTIVITIES OF CERTAIN NEW 1,4-DIHYDROPYRIDINES, PYRIDINIUM SALTS AND 2,7-DIAZABICYCLO [4.1.0] HEPT-3-ENES [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1993
3-Substituted-1-{2-chloro- or [2-bis (2-chloroethyl)amino]}ethyl-1,4-dihydropyridines 3 and 6 were prepared by reduction of the corresponding pyridinium chlorides 2 and 5 with sodium dithionite in alkaline medium.
Nawal El-Koussi, Mahmoud El-Gendy, Abdel-Alim Abdel-Alim, Hassan Farag   +3 more
doaj   +1 more source

Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

Nature Communications, 2021
1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu, Xiao-Yuan Cui, Xing-Ping Zeng, Jin-Sheng Yu, Jian Zhou   +4 more
doaj   +1 more source

Nimodipine Exerts Beneficial Effects on the Rat Oligodendrocyte Cell Line OLN-93

Brain Sciences, 2022
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Therapy is currently limited to drugs that interfere with the immune system; treatment options that primarily mediate neuroprotection and prevent ...
Felix Boltz, Michael Enders, Andreas Feigenspan, Philipp Kirchner, Arif Ekici, Stefanie Kuerten   +5 more
doaj   +1 more source