Results 41 to 50 of about 332 (138)

SYNTHESIS OF SOME 2,7-DIAZABICYCLO {4.l.0} HEPT-3-ENE DERIVATIVES WITH ANALGESIC AND ANTICOCCIDIAL ACTIVITY [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1986
The 1,3-dipolar cycloaddition reaction of arylsulphonyl azides to 1,3-disubstituted-1,4-dihydropyridines afforded 2,7-diazabieyclo {4.1.0} hept-3-ene derivatives (III).These compounds exhibited more significant analgesic and anticoccidial activities than
A. El-Badr, R. Abdel-Aal, H. Hemaiat-Allah, H. Hassan, A. Abdel-Alim, H. Farag   +5 more
doaj   +1 more source

Cancer co‐medication quality in older patients with polypharmacy: A large randomized trial testing a medication review versus usual care

Journal of Internal Medicine, EarlyView.
Abstract Background Evidence from randomized controlled trials (RCTs) testing medication reviews in geriatric oncology is sparse. Methods We conducted a single‐blinded RCT in ten rehabilitation clinics across Germany. Patients with common cancers, aged ≥ 65 years, and polypharmacy (regularly ≥ five drugs) were randomly allocated in equal proportions to
Miriam Degen, Annette Kopp‐Schneider, Tomislav Vlaski, Sigrid Carlsson, Peter Hallermann, Ludmilla Jewlanowa, Jana Barinoff, Valentin Goede, Christian Lüders, Thomas Kiefer‐Trendelenburg, Diana Lüftner, Jasmin Doll, Jürgen Wagner, Birgit Leibbrand, Hermann Brenner, Ben Schöttker   +15 more
wiley   +1 more source

Adenosine modulators and calcium channel blockers as add-on treatment for schizophrenia

npj Schizophrenia, 2021
Relapses remain common among individuals with schizophrenia indicating a need for improved treatments. Creating a completely new drug molecule is expensive and time consuming, and therefore drug repurposing should be considered.
Jonne Lintunen, Markku Lähteenvuo, Jari Tiihonen, Antti Tanskanen, Heidi Taipale   +4 more
doaj   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

An Efficient One-Pot Three-Component Synthesis of Fused 1,4-Dihydropyridines Using HY-Zeolit

Molecules, 2009
A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90 %) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.
Khalil Tabatabaeian, Mohammad Nikpassand, Manouchehr Mamaghani   +2 more
doaj   +3 more sources

Rearrangement of o-Nitrobenzaldehyde in the Hantzsch Reaction

Molecules, 2001
The reaction of 5-hydroxy-2-nitrobenzaldehyde with ethyl acetoacetate in ammonia gave the two expected isomeric 1,4- and 1,2-dihydropyridines resulting from the normal Hantzsch reaction.
R. Martínez, R. López- Castañares, A. Velázquez, A. Ramírez, I. Martínez, I. Menconi, H. Santillán, E. Angeles   +7 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Channels
Studies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease.
Tamara Theiner, Nadine J. Ortner, Herbert Oberacher, Gospava Stojanovic, Petronel Tuluc, Jörg Striessnig   +5 more
doaj   +1 more source

Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial pharmaceutical formulations.
Khanda F. M. Amin, Samar H. Elagamy, Reem H. Obaydo, Hayam M. Lotfy   +3 more
wiley   +1 more source