Results 61 to 70 of about 11,918 (214)
The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity [PDF]
, 2005 Acid-sensing ion channels (ASICs) are ion channels activated by extracellular protons. They are involved in higher brain functions and perception of pain, taste, and mechanical stimuli.
Chen, Xuanmao
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Transfer hydrosilylation [PDF]
, 2016 Transfer hydrogenation is without question a common technology in industry and academia. Unlike its countless varieties, conceptually related transfer hydrosilylations had essentially been unreported until the recent development of a radical and an ionic
Oestreich, Martin
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Beilstein Journal of Organic Chemistry, 2012 We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides.
Wafa Gati +3 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim +6 more
wiley +1 more source
Preparation of indole alkaloids via 1,4-dihydropyridine stage or cyano-masked iminium intermediates [PDF]
, 2004 Methods to synthesise substituted pyridine derivatives utilising 1,4-dihydropyridines were studied. Addition of nucleophiles to N-alkyl pyridinium salts and application of the products to alkaloid synthesis were investigated.
Putkonen, Tiina
core
Clinical Advantages of Lipophilic Dihydropyridines
Blood Pressure, 1998 Lipophilic dihydropyridines have many theoretical and practical clinical advantages owing to their long permanence at the cell membrane. They have a greater chance of smoothly and permanently reducing blood pressure over 24 h than other dihydropyridines, a feature that may have positive prognostic implications since 24-h blood pressure is more closely ...
G, Mancia, S, Omboni, A, Zanchetti
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma +12 more
wiley +1 more source
Synthesis and chromatographic-separation of the stereoisomers of furnidipine [PDF]
, 1993 The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase.
Alajarín Ferrández, Ramón +6 more
core +3 more sources
An Efficient One-Pot Three-Component Synthesis of Fused 1,4-Dihydropyridines Using HY-Zeolit
Molecules, 2009 A facile and convenient protocol was developed for the fast (2.5-3.5 h) and high yielding (70-90 %) synthesis of fused 1,4-dihydropyridines from dimedone in the presence of HY-zeolite as an efficient recyclable heterogeneous catalyst.
Khalil Tabatabaeian +2 more
doaj +3 more sources
Rearrangement of o-Nitrobenzaldehyde in the Hantzsch Reaction
Molecules, 2001 The reaction of 5-hydroxy-2-nitrobenzaldehyde with ethyl acetoacetate in ammonia gave the two expected isomeric 1,4- and 1,2-dihydropyridines resulting from the normal Hantzsch reaction.
R. MartÃÂnez +7 more
doaj +1 more source