Results 71 to 80 of about 11,918 (214)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Channels
Studies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease.
Tamara Theiner, Nadine J. Ortner, Herbert Oberacher, Gospava Stojanovic, Petronel Tuluc, Jörg Striessnig   +5 more
doaj   +1 more source

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

Beilstein Journal of Organic Chemistry, 2020
A rapid route for obtaining unsymmetrical 1,2-dihydropyridines (1,2-DHPs) as opposed to 1,4-dihydropyridines (1,4-DHPs) has been achieved via a one-pot multicomponent Hantzsch reaction.
Giovanna Bosica, Kaylie Demanuele, José M. Padrón, Adrián Puerta   +3 more
doaj   +1 more source

Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community‐dwelling older adults

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Both increased blood pressure variability (BPV) and impaired cerebral autoregulation (CA) have been linked to cerebral small vessel disease (CSVD) and cognitive performance, but whether they independently or interactively influence cognition remains unclear. METHODS We analyzed 300 community‐dwelling participants. Dynamic CA, beat‐
Nai‐Fang Chi, Li‐Ning Peng, Chun‐Jen Lin, Hao‐Min Cheng, Chen‐Huan Chen, Pei‐Ning Wang, Chih‐Ping Chung   +6 more
wiley   +1 more source

Reactions of biologically inspired hydride sources with B(C6F5)3 [PDF]

, 2017
The combination of 1-benzyl-1,4-dihydropyridines with the strong Lewis acid, B(C6F5)3, generates a stable pyridinium borohydride species in high yields (94%) in as little as 10 min.
Luk, Louis Y. P., Melen, Rebecca L., Santi, Nicolo, Wilkins, Lewis C.   +3 more
core   +1 more source

N,N'-Ethylene-bis(benzoylacetoniminato) Copper (II), Cu(C22H22N2O2), a New Reagent for Aromatization of Hantzsch 1,4-Dihydropyridines

Molecules, 2007
A variety of Hantzsch 1,4-dihydropyridines were oxidized to their corresponding pyridines in high yields in the presence of Cu(C22H22N2O2) in refluxing acetic acid.
Majid M Heravi, Saeed Dehghanpour, Fatemeh Derikvand   +2 more
doaj   +1 more source

Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]

, 1990
In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S., Kurtz, Armin, Penner, R., Skott, O.   +3 more
core   +1 more source

Enaminones in a multicomponent synthesis of 4-aryldihydropyridines for potential applications in photoinduced intramolecular electron-transfer systems

Beilstein Journal of Organic Chemistry, 2012
An efficient three component reaction with enaminones, primary amines and aldehydes resulted in easy access to 1,4-dihydropyridines with different substituents at the 1-, 3-, 4- and 5-positions.
Nouria A. Al-Awadi, Maher R. Ibrahim, Mohamed H. Elnagdi, Elizabeth John, Yehia A. Ibrahim   +4 more
doaj   +1 more source

A Microwave-Assisted Bismuth Nitrate-Catalyzed Unique Route Toward 1,4-Dihydropyridines

Molecules, 2012
The classical Hantzsch reaction is one of the simplest and most economical methods for the synthesis of biologically important and pharmacologically useful 1,4-dihydropyridine derivatives.
Bimal K. Banik, Stephanie Maldonado, Debasish Bandyopadhyay   +2 more
doaj   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source