Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
Molecules, 2015 The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions.
Brigita Vigante +9 more
doaj +1 more source
Antihypertensive medications and risk of Alzheimer's disease: Evidence for specific medication use
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.Abstract BACKGROUND Hypertension is a modifiable risk factor for Alzheimer's disease (AD). Specific antihypertensive classes may lower/increase AD risk by affecting the renin–angiotensin–aldosterone system. METHODS We investigated AD risk in relation to antihypertensive medications in a population‐based study of 33,714 incident AD cases and 897,872 ...
Osvaldo J. Laurido‐Soto +6 more
wiley +1 more source
Journal of Cardiovascular Electrophysiology, Volume 37, Issue 4, Page 859-863, April 2026.ABSTRACT Introduction Currently, there are no available fast‐acting agents to control the ventricular rate (VR) during atrial fibrillation (AF) episodes that can be self‐administered by patients on an as‐needed basis without medical supervision. Here, we aim to evaluate the effect of intranasal etripamil on VR in patients treating presumed paroxysmal ...
Paul Dorian +10 more
wiley +1 more source
Dihydropyridine derivatives modulate heat shock responses and have a neuroprotective effect in a transgenic mouse model of Alzheimer’s disease [PDF]
, 2016 Heat shock proteins (Hsps) have chaperone activity and play a pivotal role in the homeostasis of proteins by preventing misfolding, by clearing aggregated and damaged proteins from cells and by maintaining proteins in an active state. Alzheimer’s disease
Balogh, Gábor +15 more
core +1 more source
Calcium channel blockers revisited [PDF]
, 2002 published_or_final_versio
Cheung, BMY, Kumana, CR
core
Oxygen-Induced Dimerization of Alkyl-Manganese(II) 2,6-Bisiminopyridine Complexes: Selective Synthesis of a New Ditopic NNN-Pincer Ligand [PDF]
, 2016 The outcome of the reaction of manganese(II) dialkyls with 2,6-bisiminopyridine (BIP) ligands is dramatically altered by the presence of very small amounts of oxygen (< 0.5 mol %), leading to binuclear species.
Cámpora Pérez, Juan +5 more
core +4 more sources
Catalytic Intermolecular Hetero-Dehydro-Diels–Alder Cycloadditions: Regio- and Diasteroselective Synthesis of 5,6-Dihydropyridin-2-ones [PDF]
, 2011 A novel catalyzed intermolecular heterodehydro-Diels–Alder reaction between push–pull 1,3-dien-5-ynes and aldimines or silylaldimines is reported.
Aguilar, Enrique +2 more
core +1 more source
Кардиоваскулярная терапия и профилактика, 2010 Background. Results from clinical studies suggest that the dihydropyridine calcium channel blocker (d-CCB) lercanidipine may be associated with a lower incidence of peripheral edema than are older d-CCBs. Aim. To conduct a meta-analysis of published data
K. Makarounas-Kirchmann +2 more
doaj
Results in ChemistryDihydropyridines (DHPs) exhibit a wide range of pharmacological properties especially against cancer. In this context, a new series of 1,4-dihydropyridines were meticulously designed employing scaffold hybridization technique targeting the EGFR/HER2 ...
A.S.V.L. Sruthi +8 more
doaj +1 more source
CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons [PDF]
, 2007 The inhibitor cystine-knot motif identified in the structure of CSTX-1 from Cupiennius salei venom suggests that this toxin may act as a blocker of ion channels.
Beirão, PSL +8 more
core +1 more source