Results 81 to 90 of about 4,532 (195)

Antileishmanial and Antitoxoplasmal Activities of 1,4-dihydropyridines

ACS Omega
We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reaction and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major. We have found that compound 9 ((±)-ethyl 2,7,7-trimethyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,
Thaís Oliveira, Yan Robles, Ibrahim Al Nasr, Waleed Koko, Tariq Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha Ben Said, Antônio Crotti   +9 more
openaire   +3 more sources

Fixed‐Dose Combinations for Hypertension: Barriers to Use and Opportunities for Health Systems

The Journal of Clinical Hypertension, Volume 28, Issue 6, June 2026.
ABSTRACT Background: Uncontrolled hypertension is a leading driver of heart disease, chronic kidney disease, heart failure, dementia, stroke, and pregnancy‐related complications. Fixed‐dose combinations (FDCs) are guideline‐endorsed first‐line therapies that improve blood pressure control by reducing pill burden, improving adherence, and targeting ...
Pranay Narang, Josselyne Marquez, Neema Rashidi, Rohini Haar, Sandeep P. Kishore   +4 more
wiley   +1 more source

Organophotoredox/Cobalt‐Catalyzed Retro‐Hydroformylation of Aldehydes

ChemistryEurope
A new cobalt/organophotoredox dual catalytic system is reported for the efficient retro‐hydroformylation of aldehydes. Under the optimized conditions, a wide range of α‐monosubstituted aldehydes are readily transformed into the desired alkenes in a one ...
Augustin Nouaille, Emmanuel Magnier, Corinne Gosmini, Guillaume Dagousset   +3 more
doaj   +1 more source

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Heart failure with preserved ejection fraction (HFpEF) is associated with skeletal muscle dysfunction that contributes to exercise intolerance and disease progression. Altered Ca2+ homeostasis and increased oxidative stress have been proposed as mechanisms underlying muscle weakness in HFpEF; however, the effects of aerobic exercise on ...
Cielo Martínez Martínez, Jorge Fragoso Medina, Estefanía Bravo Sánchez, Bianca Nieblas, Alfredo Saavedra Molina, Christian Cortés Rojo, Salvador Manzo Ávalos, Noemí García, Rocío Montoya Pérez   +8 more
wiley   +1 more source

Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2002
The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi, Yousef Ahmadibeni   +1 more
doaj  

Synthesis of 2-Mono and 2,6-Disubstituted Methyl-1,4-Dihydropyridines [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1997
The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.
Yousef Rastgar Mirzaei, Karim Akbari Dilmaghani   +1 more
doaj  

AROMATIZATION OF 1,4-DIHYDROPYRIDINES WITH FREE RADICAL REAGENTS [PDF]

Journal of Sciences, Islamic Republic of Iran, 2001
Oxidation of different types of 1,4-dihydropyridines with diphenylpicrylhydrazyl (DPP) and benzoyl peroxide (Bz2O2) as free radical oxidizing agents to pyridine derivatives is reported and a mechanism for this oxidation is also proposed.
doaj  

AROMATIZATION OF 1 , CDIHYDROPYRIDINES WITH OXYGEN OR AIR USING MANGANESE AND COBALT SALTS OF p-AMINOBENZOIC ACID SUPPORTED ON SILICA GEL AS OXIDIZING CATALYSTS [PDF]

Journal of Sciences, Islamic Republic of Iran, 1998
Hantzsch 1,4-dihydropyridines are oxidized to the corresponding pyridine derivatives using oxygen or air and a mixture of the manganese and cobalt salts of parninobenzoic acid supported on silica gel as the catalysts.
doaj  

Rapid Access to 1,2,3,4-Tetrasubstituted Benzenes and 3‑Alkenyl-1,2-dihydropyridines. [PDF]

ACS Omega
Dundar Ozdogan BA, Zora M.
europepmc   +1 more source

Evaluation of Novel Benzo-Annelated 1,4-Dihydropyridines as Potential Inhibitors of Antibacterial Efflux Pumps in <i>S. aureus</i> and MRSA Strains. [PDF]

Int J Mol Sci
Werner P, Szemerédi N, Spengler G, Erdmann F, Hilgeroth A.   +4 more
europepmc   +1 more source