Results 101 to 110 of about 4,506 (161)

Chemistry of dihydropyridines

Chemical Reviews, 1972
Ulli. Eisner, Josef. Kuthan
exaly   +2 more sources

ChemInform Abstract: 1,2‐Dihydropyridines, 1,4‐Dihydropyridines, and Derivatives

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J.‐C. Quirion, E. Leclerc, P. Jubault
openaire   +1 more source

Coumarin 1,4-Dihydropyridine Derivatives

Bioorganic & Medicinal Chemistry, 1998
A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium antagonist activities. The replacement of the o-nitrophenyl moiety of nifedipine with a coumarin or phenylcoumarin system is accompanied by a decrease of the activity on myocardial and vascular ...
Valenti P., Rampa A., Budriesi R., Bisi A., Chiarini A.   +4 more
openaire   +2 more sources

(Trihalogenmethyl)dihydropyridine

Chemische Berichte, 1977
Abstract1‐(2,6‐Dichlorbenzyl)‐ und 1‐Ethylpyridinium‐Salze ergeben mit Haloformat‐Anionen (Trihalogenmethyl)dihydropyridine. Je nach dem verwendeten Haloform werden primär nur die 1,2‐ oder die 1,4‐Dihydropyridine gebildet. Die 2‐(Trichlormethyl)‐1,2‐dihydropyridine 1 lagern sich in polaren, aprotischen Lösungsmitteln in die 4‐(Trichlormethyl)‐1,4 ...
Karl Heinz Duchardt, Fritz Kröhnke
openaire   +1 more source

Synthesis of Spiro1,4–Dihydropyridines: A Review

Current Organic Synthesis, 2020
The preparation of medicinally promising spiro1,4–dihydropyridines accompanied by their applications in biological and pharmaceutical activities is presented. Spiro1,4–dihydropyridines were synthesized using numerous reported methods including bronested acids such as p-TSA, AcOH, nano-ranged calix[4]arene tetracarboxylic acid, sulfamic acid, PEG ...
Zahra Sadri, Farahnaz K. Behbahani
openaire   +2 more sources

1,4-Dihydropyridines and the 1,4-Dihydropyridine Receptor

1993
The 1,4-dihydropyridine nifedipine is a first-generation drug of major significance in the treatment of cardiovascular disorders including hypertension, peripheral vascular disorders and angina in its several forms. Nifedipine is one of a chemically and pharmacologically heterogeneous group of drugs that includes also verapamil and diltiazem and which ...
openaire   +1 more source

Hantzsch Dihydropyridine Synthesis

2009
1,4-Dihydropyridine from the condensation of aldehyde, β-ketoester and ammonia. Hantzsch 1,4-dihydropyridines are popular reducing reagents in organo-catalysis.
openaire   +1 more source

Dihydropyridines on guinea-pig ileum

General Pharmacology: The Vascular System, 1990
1. The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM).
I, Martin, I, Colado, V, del Val, M J, Alfaro   +3 more
openaire   +2 more sources

The Dihydropyridine Receptors

1985
The purpose of this chapter is to review some of the recent studies on the characterization of 1,4-dihydropyridine receptors (DHPRs). In this respect the chapter will complement the contributions of Glossmann, Nayler and Schwartz (this volume) and the previously published reviews of 1,4-dihydropyridine (DHP) binding studies (Meyer et al.
R. A. Janis, P. Bellemann, J. G. Sarmiento, D. J. Triggle   +3 more
openaire   +1 more source

Antihypertensive dihydropyridines with 1,4,4-trisubstitution

Journal of Medicinal Chemistry, 1990
Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds.
M J, Kukla, H J, Breslin, A, Gill
openaire   +2 more sources