The role of amlodipine (norvasc) in Cardiology
The review concerns amlodipine - the representative of the third generation of dihydropyridines. Amlodipine, being considered a hypotensive drug, has a broad spectrum of clinical effects beyond the hypotensive effects.
D. M Aronov
doaj
Morbidity and Mortality with Dihydropyridines
Calcium antagonists (CaAs) of the dihydropyridine type are widely used in the treatment of hypertension and other cardiovascular disorders. They are markedly effective in lowering elevated arterial pressure, and are well tolerated. Data from long-term intervention trials are emerging, which also show a beneficial effect on cardiovascular morbidity with
openaire +2 more sources
Synthesis and antimicrobial evaluation of new 1,4-dihydro-4-pyrazolylpyridines and 4-pyrazolylpyridines [PDF]
Background Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates (1,4-DHP) have now been recognized as vital drugs. Some of these derivatives such as amlodipine, felodipine, isradipine, etc. have been commercialized.
Om Prakash +5 more
core +1 more source
Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate [PDF]
Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.
Mohammad Mahmoodi Hashemi +2 more
doaj
1,4-Dihydropyridines (DHPs) have been used in the reduction of carbon-carbon double bonds under microwave irradiation without solvent. The efficiency of the reactions is dramatically dependent on the steric effects in the DHPs and on the electronic ...
Jean Jacques Vanden Eynde +3 more
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How European cardiologists perceive the role of calcium antagonists in follow-up after myocardial infarction [PDF]
About one hundred European cardiologists discussed the role of calcium antagonists in the follow-up management of myocardial infarction, β-blockers are the treatment of choice.
Ferrari, R. +3 more
core
Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]
The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi +1 more
doaj
An In-Depth Examination of Formularies and Other Features of Medicare Drug Plans [PDF]
Provides a detailed assessment of the formularies, drug costs, and utilization management tools offered by the fourteen nationwide organizations that account for most of the stand-alone prescription drug ...
Elizabeth Hargrave +3 more
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Application of a new high performance liquid chromatography method to the pharmacokinetics of dibudipine in rats [PDF]
Purpose: To develop a HPLC method for assay of dibudipine in biological fluids and to study its pharmacokinetics in the rat. Methods. HPLC: 2 μl (20 μg/ml) mebudipine as internal standard, 0.2 ml NaOH 1 M and 2 ml ethyl acetate were added to 0.2 ml of ...
بهلولی, شهاب +3 more
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Synthesis of 2-Mono and 2,6-Disubstituted Methyl-1,4-Dihydropyridines [PDF]
The 2-mono and 2,6-disubstituted methyl-1,4-dihydropyridines were synthesized by reaction of morpholine, thiophenol, 8-hydroxyquinoline, 2-naphthol and 2-mercopto-1-methyl imidazole with the 2-mono bromo and 2,6-dibromo-1,4-dihidropyridines.
Yousef Rastgar Mirzaei +1 more
doaj

