Results 31 to 40 of about 4,506 (161)

The unique reactivity of 5,6-unsubstituted 1,4-dihydropyridine in the Huisgen 1,4-diploar cycloaddition and formal [2 + 2] cycloaddition

Beilstein Journal of Organic Chemistry, 2023
The three-component reaction of isoquinolines, dialkyl acetylenedicarboxylates, and 5,6-unsubstituted 1,4-dihydropyridines in acetonitrile at room temperature afforded functionalized isoquinolino[1,2-f][1,6]naphthyridines in good yields and with high ...
Xiu-Yu Chen, Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +4 more
doaj   +1 more source

Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione

Molecules, 2011
Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4 ...
Fernando Albericio, Nazario Martín, Hortensia Rodríguez, Osnieski Martin, Margarita Suarez   +4 more
doaj   +1 more source

New synthetic method for the synthesis of 1,4-dihydropyridine using aminated multiwalled carbon nanotubes as high efficient catalyst and investigation of their antimicrobial properties

Journal of Saudi Chemical Society, 2018
Synthesis of 1,4-dihydropyridines in the presence of aminated multiwalled carbon nanotubes and investigation into their antimicrobial properties were carried out.Amino functionalized carbon nanotubes were prepared through a facile, clean and safe ...
Roya Mahinpour, Leila Moradi, Zohreh Zahraei, Nafiseh Pahlevanzadeh   +3 more
doaj   +1 more source

4-Aryldihydropyrimidines via the Biginelli Condensation: Aza-Analogs of Nifedipine-Type Calcium Channel Modulators

Molecules, 1998
Recent results from the author's laboratory in the area of dihydropyrimidine chemistry are summarized.
C. Oliver Kappe
doaj   +1 more source

Crystal structure of 2-amino-4-(4-chlorophenyl)-1-(4-methylphenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C23H20ClN3O, each of the cyclohexene and 1,4-dihydropyridine rings of the 1,4,5,6,7,8-hexahydroquinoline ring system adopts a twisted-boat conformation. The dihedral angle between the two benzene rings is 11.52 (7)°. In the crystal,
Shaaban K. Mohamed, Mehmet Akkurt, Jerry P. Jasinski, Omyma A. A. Abd Allah, Mustafa R. Albayati   +4 more
doaj   +1 more source

Morbidity and Mortality with Dihydropyridines

Blood Pressure, 1998
Calcium antagonists (CaAs) of the dihydropyridine type are widely used in the treatment of hypertension and other cardiovascular disorders. They are markedly effective in lowering elevated arterial pressure, and are well tolerated. Data from long-term intervention trials are emerging, which also show a beneficial effect on cardiovascular morbidity with
openaire   +2 more sources

DIHYDROPYRIDINE CALCIUM ANTAGONISTS: DATA OF EVIDENCE BASED MEDICINE AND RECOM-MENDATIONS ON PRACTICAL USE

Рациональная фармакотерапия в кардиологии, 2015
The classification of calcium antagonists is presented. There were considered the results of large randomized trials, which were devoted to study of influence of dihydropyridine calcium antagonists on the risk of cardiovascular complications.
S. Y. Martsevich
doaj   +1 more source

Adenosine modulators and calcium channel blockers as add-on treatment for schizophrenia

npj Schizophrenia, 2021
Relapses remain common among individuals with schizophrenia indicating a need for improved treatments. Creating a completely new drug molecule is expensive and time consuming, and therefore drug repurposing should be considered.
Jonne Lintunen, Markku Lähteenvuo, Jari Tiihonen, Antti Tanskanen, Heidi Taipale   +4 more
doaj   +1 more source

Acyl-1,4-Dihydropyridines: Universal Acylation Reagents for Organic Synthesis

Molecules
Acyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals.
Karthikeyan Manoharan, Bartosz Bieszczad
doaj   +1 more source

Intramolecular carbolithiation of N-allyl-ynamides: an efficient entry to 1,4-dihydropyridines and pyridines – application to a formal synthesis of sarizotan

Beilstein Journal of Organic Chemistry, 2012
We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides.
Wafa Gati, Mohamed M. Rammah, Mohamed B. Rammah, Gwilherm Evano   +3 more
doaj   +1 more source