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Antischistosomal Activity of 1,4-Dihydropyridines
Drugs and Drug CandidatesBackground/Objectives: Recent reports have demonstrated the antiparasitic activity of 1,4-dihydropyridine (1,4-DHPs). This study aimed to assess the in vitro antischistosomal activity of 24 1,4-DHPs against Schistosoma mansoni adult worms.
Thaís A. S. Oliveira +5 more
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Dimethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Acta Crystallographica Section E, 2009 In the crystal of the title compound, C11H15NO4, the molecules are linked into sheets by N—H...O and C—H...O hydrogen bonds.
Zhenfeng Zhang +3 more
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Ethyl 4-oxo-1,4-dihydropyridine-3-carboxylate
IUCrData, 2021 The title compound, C8H9NO3, likely generated through hydrolysis and esterification of 3′-carboxy-3-methyl-(1,4′-bipyridin)-1-ium chloride by ethanol, which contained water, has a nearly planar conformation.
Jun Gao, Sihui Long
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Diversity of felodipine solvates: Structure and physicochemical properties [PDF]
, 2015 Solvates of the calcium-channel blocking agent felodipine with three structurally related common organic solvents, acetone (ATN), dimethyl sulfoxide (DMSO) and acetophenone (APN), are described.
Bauer-Brandl, A +4 more
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Effects of an antimutagen of 1,4-dihydropyridine series on cell survival and DNA damage in L5178Y murine sublines [PDF]
, 2006 In a series of studies it was shown that 1,4-dihydropyridine derivatives (1,4-DHP) show antimutagenic and anticlastogenic properties and accelerate repair of oxidant and ionising radiation generated DNA damage.
Dalivelya, Olga +1 more
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Sirtuin functions and modulation: from chemistry to the clinic [PDF]
, 2016 Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia +9 more
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Results in Chemistry, 2023 Derivatives of dihydropyridines are promising agents for research, as they have high biological activity. Their low toxicity and polytargeted properties make it possible to create new derivatives and identify new biological activity. As part of this work,
Arkadiy Bryzgalov +3 more
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Synthesis and in vitro Evaluation of the Antimycobacterial Activity of N-aryl-1,4-dihydropyridine-3,5-dicarboxamides [PDF]
Journal of Sciences, Islamic Republic of Iran, 2012 Dihydropyridines (DHPs) with carboxamides in the 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs that would possibly possess anti-tuberculosis activity.
F. Mohammadpour
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Rat cerebral cortical synaptoneurosomal membranes. Structure and interactions with imidazobenzodiazepine and 1,4-dihydropyridine calcium channel drugs [PDF]
, 1990 Small angle x-ray scattering has been used to investigate the structure of synaptoneurosomal (SNM) membranes from rat cerebral cortex. Electron micrographs of the preparation showed SNM with classical synaptic appositions intact, other vesicles ...
Moring, J. +6 more
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Green Chemistry Letters and Reviews, 2020 The reaction of 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbohydrazide with variety of carbonyl compounds such as substituted benzaldehydes, cycloalkanones and hetero-cyclic ketones under grinding method under catalyst- and solvent-free ...
Sobhi M. Gomha +4 more
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