Results 11 to 20 of about 8,139 (202)

An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates [PDF]

Beilstein Journal of Organic Chemistry, 2022
A method has been developed for the preparation of 2-alkyl-6-aryl-, 2-aryl-6-aryl and 2,6-diaryl-5-aryl/hetaryl-substituted methyl 4-oxo-1,4-dihydropyridine-3-carboxylates by Mo(CO)6-mediated ring expansion of methyl 2-(isoxazol-5-yl)-3-oxopropanoates ...
Timur O. Zanakhov, Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov   +3 more
doaj   +2 more sources

Comparison between 1,2-Dihydropyridine and 1,4-Dihydropyridine on Hydride-Donating Ability and Activity [PDF]

Molecules, 2022
In this paper, detailed comparisons of the driving force in thermodynamics and intrinsic force in the kinetics of 1,2-dihydropyridine and 1,4-dihydropyridine isomers of PNAH, HEH, and PYH in hydride transfer reactions are made. For 1,2-PNAH and 1,4-PNAH,
Jin-Ye Zhang, Xiao-Qing Zhu
doaj   +2 more sources

First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives [PDF]

Molecules, 2018
Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported.
Fernando Auria-Luna, Eugenia Marqués-López, Raquel P. Herrera   +2 more
doaj   +2 more sources

Catalytic efficiency of GO-PANI nanocomposite in the synthesis of N-Aryl-1,4-Dihydropyridine and hydroquinoline derivatives [PDF]

Scientific Reports
In this research, graphene oxide-polyaniline (GO-PANI) nanocomposite was successfully synthesized and its catalytic performance was evaluated for the synthesis of N-aryl-1,4-dihydropyridine (1,4-DHP) and hydroquinoline derivatives. The GO nanosheets were
Hossein Ghafuri, Moghadaseh keshvari, Fatemeh Eshrati, Peyman Hanifehnejad, Atefeh Emami, Hamid Reza Esmaili Zand   +5 more
doaj   +2 more sources

RETRACTED: Synthesis of efficient cobalt–metal organic framework as reusable nanocatalyst in the synthesis of new 1,4-dihydropyridine derivatives with antioxidant activity

Frontiers in Chemistry, 2022
Efficient cobalt–metal organic framework (Co-MOF) was prepared via a controllable microwave-assisted reverse micelle synthesis route. The products were characterized by SEM image, N2 adsorption/desorption isotherm, FTIR spectrum, and TG analysis. Results
Omar dheyauldeen Salahdin, Indrajit Patra, Mohammad Javed Ansari, Samar Emad Izzat, Khusniddin Fakhriddinovich Uktamov, Mohammed Kadhem Abid, Ahmed B. Mahdi, Ali Thaeer Hammid, Yasser Fakri Mustafa, Himanshu Sharma   +9 more
doaj   +2 more sources

Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives. [PDF]

R Soc Open Sci, 2018
1,4-Dihydropyridine (1,4-DHP) derivatives have been synthesized and characterized by 1 H, 13 C, 15 N nuclear magnetic resonance (NMR) spectroscopy, secondary proton/deuterium 13 C isotope shifts, variable temperature 1 H ...
Petrova M, Muhamadejev R, Vigante B, Duburs G, Liepinsh E.   +4 more
europepmc   +5 more sources

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +2 more sources

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates. [PDF]

Molecules, 2015
The ethoxycarbonylmethyl esters of 1,4-dihydropyridines were directly converted into carbamoylmethyl esters in the presence of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) in good to excellent yields under mild conditions. The use of TBD is crucial for the successful aminolysis of ethoxycarbonylmethyl ester of 1,4-dihydropyridines with secondary amines as
Vigante B, Rucins M, Plotniece A, Pajuste K, Luntena I, Cekavicus B, Bisenieks E, Smits R, Duburs G, Sobolev A.   +9 more
europepmc   +5 more sources

Synthesis and assessment of the cytotoxic effect of some of 1,4-dihydropyridine derivatives which contain azole moiety [PDF]

Journal of the Serbian Chemical Society, 2021
A number of 1,4-dihydropyridine derivatives (9a–d, 10a–d and 11a–d) were designed and synthesized by the reaction of 1,3,4-oxadiazole-5-thiones and 1,2,4-triazole-5-thiones to 2,6-dibromomethyl-3,5-diethoxycarbonyl-4-(3- -nitrophenyl)-1,4-dihydropyridine.
Ghoorbannejad Saeed, Akbari Dilmaghani Karim, Nikoo Abbas   +2 more
doaj   +1 more source

3-Methyl 5-{3-[(4-Methylbenzenesulfonyl)oxy]propyl} 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Molbank, 2022
The 1,4-dihydropyridine is a ubiquitous scaffold employed not only in medicinal chemistry but also in organic synthesis, given its ability to act as a hydrogen transfer reagent, thus emulating NAD(P)H reducing agents.
Carlotta Borgarelli, Stijn Lenaers, Wim M. De Borggraeve, Ermal Ismalaj   +3 more
doaj   +1 more source