Results 11 to 20 of about 4,494 (179)

Study of novel 1,4-dihydropyridine derivatives as prospective anti-inflammatory remedies: a randomised controlled trial

Кубанский научный медицинский вестник, 2022
Background. Over the past decades, scientific community is motivated on finding new anti-inflammatory agents with a safe and high-effective profile to manage pathology.Objectives. A study of the anti-inflammatory action of novel compounds, 1,4-dihydropyridine
E. Yu. Bibik, D. S. Krivokolysko, G. A. Batishcheva, A. A. Samokish, Yu. S. Venidiktova, A. V. Myazina, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko   +9 more
doaj   +1 more source

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines

Data in Brief, 2020
In this data file the synthetic procedures for preparation of the original 4-pyridinium-1,4-dihydropyridines (4-Py-1,4-DHP) and their parent compounds – dialkyl 2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylates were described. In total, 5
Klavs Pajuste, Martins Rucins, Ilona Domracheva, Arkadij Sobolev, Nadiia Pikun, Mara Plotniece, Gunars Duburs, Karlis Pajuste, Aiva Plotniece   +8 more
doaj   +1 more source

Novel 1,4-Dihydropyridine Derivatives as Potential Agents with Analgesic Activity IN Orofacial Trigeminal Pain Test: Experimental Preclinical Randomized Trial

Кубанский научный медицинский вестник, 2023
Background. In the majority of cases, contemporary pharmacological correction mainly focuses on the most effective analgesia. Therefore, the search for and research into new analgesic drugs are a priority in modern pharmacology.Objective — to establish ...
E. Yu. Bibik, I. S. Oleynik, A. A. Pankov, K. A. Frolov, V. V. Dotsenko, S. G. Krivokolysko   +5 more
doaj   +1 more source

Dimethyl 4-(4-formylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2008
The title compound, C18H19NO5, is a product of the Hantzsch reaction of p-phthalaldehyde, methyl acetoacetate, and ammonium acetate. The 1,4-dihydropyridine ring of the molecule adopts a flattened boat conformation.
Fei Teng, Fanpeng Kong, Qingjian Liu
doaj   +1 more source

Diisopropyl 1-(4-methoxyphenyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2011
In the title compound, C28H32N2O7, the 1,4-dihydropyridine ring adopts a flattened boat conformation. The two benzene rings are approximately perpendicular to the dihydropyridine ring, forming dihedral angles of 84.29 (9) and 82.96 (9)
Kamini Kapoor, Vivek K. Gupta, Rajni Kant, Milind P. Pawar, Hitendra S. Joshi   +4 more
doaj   +1 more source

Development of Self-Assembling bis-1,4-Dihydropyridines: Detailed Studies of Bromination of Four Methyl Groups and Bromine Nucleophilic Substitution

Molecules, 2023
One of the most important steps in the synthesis of 1,4-dihydropyridine (1,4-DHP) amphiphiles is the bromination of methyl groups in positions 2 and 6 of the entire ring.
Martins Kaukulis, Martins Rucins, Davis Lacis, Aiva Plotniece, Arkadij Sobolev   +4 more
doaj   +1 more source

Synthesis, crystal structure and Hirshfeld surface analysis of diethyl 2,6-dimethyl-4-(thiophen-3-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title compound, C17H21NO4S, the 1,4-dihydropyridine ring has an envelope conformation with the Csp3 atom at the flap. The thiophene ring is nearly perpendicular to the best plane through the 1,4-dihydropyridine ring, the dihedral angle being 82.19 
Trung Vu Quoc, Duong Tran Thi Thuy, Thanh Phung Ngoc, Manh Vu Quoc, Hien Nguyen, Linh Duong Khanh, Anh Tu Quang, Luc Van Meervelt   +7 more
doaj   +1 more source

Data for characterisation of nanoformulations formed by cationic 1,4-dihydopyridine and calix[4]arene compositions

Data in Brief, 2022
In this data file the characterisation of nanoformulations obtained from calix[4]arene/1,4-dihydropyridine (1,4-DHP) compositions in the various component ratio in an aqueous medium was performed by dynamic light scattering (DLS) technique.
Martins Rucins, Roman Rodik, Aiva Plotniece, Nadiia Pikun, Mara Plotniece, Arkadij Sobolev, Vitaly Kalchenko, Karlis Pajuste   +7 more
doaj   +1 more source

1,1′-{[3,5-Bis((dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]bis(methylene)}bis[4-(anthracen-9-yl)pyridin-1-ium] Dibromide

Molbank, 2022
A synthesis of a cationic moiety and fluorescent moieties containing amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives was performed starting with the Hantzsch-type cyclization of dodecyl acetoacetate, phenylaldehyde and ammonium acetate. Bromination
Reinis Ozolins, Mara Plotniece, Karlis Pajuste, Reinis Putralis, Nadiia Pikun, Arkadij Sobolev, Aiva Plotniece, Martins Rucins   +7 more
doaj   +1 more source

Diethyl 4-(1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

IUCrData, 2019
In the title compound, C21H24N2O4, the 1,4-dihydropyridine ring adopts a very flattened boat conformation, with the 3-pyridine substituent in an axial orientation.
Ji Hye Lee, Dongsoo Koh
doaj   +1 more source