Results 41 to 50 of about 370,384 (214)

Use of pyridinium ionic liquids as catalysts for the synthesis of 3,5-bis(dodecyloxycarbonyl)-1,4-dihydropyridine derivative [PDF]

, 2010
The synthesis of cationic amphiphilic 1,4-dihydropyridine derivative, potential gene delivery agent is achieved via an efficient multi-step sequence.
Kore Kintija, Brigita Cekavicus, Sobolev Arkadij, Pajuste, Karlis, Plotniece, Aiva, Kaldre, Dainis, Dainis Kaldre, Kaldre Dainis, Liva Intenberga, Plotniece Aiva, Aiva Plotniece, Duburs Gunars, Gunars Duburs, Arkadij Sobolev, Sobolev, Arkadij, Duburs, Gunars, Kore, Kintija, Intenberga, Liva, Karlis Pajuste, Pajuste Karlis, Kintija Kore, Intenberga Liva, Cekavicus Brigita, Cekavicus, Brigita   +23 more
core   +1 more source

Dimethyl 2,6-dimethyl-4-(3-phenyl-1H-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2012
In the title compound, C20H21N3O4, the 1,4-dihydropyridine ring adopts a boat conformation. An intramolecular C—H...O hydrogen bond generates an S(6) ring motif. The pyrazole ring makes dihedral angles of 87.81 (7) and 45.09 
Hoong-Kun Fun, Suhana Arshad, Shridhar Malladi, Kammasandra Nanjunda Shivananda, Arun M. Isloor   +4 more
doaj   +1 more source

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +1 more source

Sodium N-(3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carbonyl)-l-methioninate

Molbank, 2020
The development of the methods for amide bond formation is important for various uses in the laboratory and industrial applications. The compounds combined in their structures 1,4-dihydroisonicotinic acids and amino acids linked with an amide bond can be
Egils Bisenieks, Janis Poikans, Aiva Plotniece, Eiva Bernotiene, Wei-Bor Tsai, Arkadij Sobolev   +5 more
doaj   +1 more source

7-(3-Nitrophenyl)-9,10-dihydro-7H-benzo[h]cyclopenta[b]quinolin-8(11H)-one

Acta Crystallographica Section E, 2011
In the title compound, C22H16N2O3, the naphthalene ring, the 1,4-dihydropyridine ring and the cyclopent-2-enone ring are nearly coplanar, with the dihedral angles between the neighbouring rings being 1.93 (11) and 2.30 (9)&#176 ...
Tuanjie Li, Honghong Zhang
doaj   +1 more source

Gold‐Catalyzed Cyclization of Indole‐Tethered Alkynes Enabling Synthesis of Exocyclic Alkenyl Tetrahydrocarbazoles

European Journal of Organic Chemistry, EarlyView.
An efficient gold‐catalyzed intramolecular cyclization of indole‐tethered alkynes using AgNTf2 as an additive has been developed, which provides bioactive exocyclic alkenyl tetrahydrocarbazoles with up to 85% yield. Control experiments and DFT studies indicate that the reaction proceeds via a 6‐exo‐dig cyclization pathway, with gold acetylide complexes
Haibo Mei, Jingrui He, Chengting Wang, Jorge Escorihuela, Jianlin Han   +4 more
wiley   +1 more source

Rearrangement of o-Nitrobenzaldehyde in the Hantzsch Reaction

Molecules, 2001
The reaction of 5-hydroxy-2-nitrobenzaldehyde with ethyl acetoacetate in ammonia gave the two expected isomeric 1,4- and 1,2-dihydropyridines resulting from the normal Hantzsch reaction.
R. Martínez, R. López- Castañares, A. Velázquez, A. Ramírez, I. Martínez, I. Menconi, H. Santillán, E. Angeles   +7 more
doaj   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Ethyl 4-oxo-1,4-dihydropyridine-3-carboxylate

IUCrData, 2021
The title compound, C8H9NO3, likely generated through hydrolysis and esterification of 3′-carboxy-3-methyl-(1,4′-bipyridin)-1-ium chloride by ethanol, which contained water, has a nearly planar conformation.
Jun Gao, Sihui Long
doaj   +1 more source

Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher, Fiona L. Motel, Felix F. Lillich, Astrid Kaiser, Ewgenij Proschak, Pascal Heitel   +5 more
wiley   +1 more source